Judith E. Karp (editor) - Cancer pharmacology : an illustrated manual of anticancer drugs

i ii Cancer Pharmacology

An Illustrated Manual of Anticancer Drugs

Editors

Ashkan Emadi, MD, PhD

Professor, Medicine and Pharmacology
Associate Director for Clinical Research
Marlene and Stewart Greenebaum Comprehensive Cancer Center
Director, Translational Genomics Laboratory
University of Maryland School of Medicine
Baltimore, Maryland

Judith E. Karp, MD

Professor Emerita, Oncology and Medicine
Sidney Kimmel Comprehensive Cancer Center
Johns Hopkins University
Baltimore, Maryland

iii

iv Visit our website at www.springerpub.com and http://connect.springerpub.com/home

ISBN: 978-0-8261-6203-8

ebook ISBN: 978-0-8261-6204-5

DOI: 10.1891/9780826162045

Acquisitions Editor: David DAddona

Compositor: S4Carlisle Publishing Services

Copyright 2020 Springer Publishing Company, LLC.

Demos Medical Publishing is an imprint of Springer Publishing Company, LLC.

All rights reserved. This book is protected by copyright. No part of it may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher.

Medicine is an ever-changing science. Research and clinical experience are continually expanding our knowledge, in particular our understanding of proper treatment and drug therapy. The authors, editors, and publisher have made every effort to ensure that all information in this book is in accordance with the state of knowledge at the time of production of the book. Nevertheless, the authors, editors, and publisher are not responsible for errors or omissions or for any consequences from application of the information in this book and make no warranty, expressed or implied, with respect to the contents of the publication. Every reader should examine carefully the package inserts accompanying each drug and should carefully check whether the dosage schedules mentioned therein or the contraindications stated by the manufacturer differ from the statements made in this book. Such examination is particularly important with drugs that are either rarely used or have been newly released on the market.

Library of Congress Cataloging-in-Publication Data

Names: Emadi, Ashkan, editor. | Karp, Judith E., editor.

Title: Cancer pharmacology : an illustrated manual of anticancer drugs / editors, Ashkan Emadi, Judith E. Karp.

Description: New York : Demos Medical, [2020] | Includes bibliographical references and index.

Identifiers: LCCN 2019043551 (print) | LCCN 2019043552 (ebook) | ISBN 9780826162038 (softcover) | ISBN 9780826162045 (ebook)

Subjects: MESH: Antineoplastic Agents--pharmacology | Neoplasms--drug therapy

Classification: LCC RC271.C5 (print) | LCC RC271.C5 (ebook) | NLM QZ 267 | DDC 616.99/4061--dc23

LC record available at https://lccn.loc.gov/2019043551

LC ebook record available at https://lccn.loc.gov/2019043552

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Printed in the United States of America.

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v We dedicate this book to the chemists, biologists, pharmacologists, clinicians and clinical investigators, and patients and their families who continue to improve the lives of patients with cancerand to science and its divinity. vi

vii Contents

Edward A. Sausville

Ali Bukhari and Ashkan Emadi

Crystal Lu, Judith E. Karp and Ashkan Emadi

Justin Lawson and Edward A. Sausville

Edward A. Sausville

Mira A. Kohorst and Scott H. Kaufmann

Lukasz P. Gondek

Gabriel Ghiaur

Amy Fulton and Katherine H. R. Tkaczuk

Vincent C. O. Njar and Arif Hussain

Michael G. McCusker Jr.,Katherine A. Scilla, and Christian Rolfo

Alison Duffy and Ciera Patzke

Mark Yarchoan and Elizabeth Jaffee

Mehmet Kocoglu

Jean Yared and Saurabh Dahiya

Sonia Esparza and Joshua Zeidner

S. Percy Ivy and Richard F. Little

Olanrewaju O. Okusanya,Ruby Leong,Matthew D. Thompson, and Donna Przepiorka

xiv

xv Contributors

Ali Bukhari, MD Hematology/Oncology Fellow, University of Maryland, Baltimore, Maryland

Saurabh Dahiya, MBBS Assistant Professor of Medicine, University of Maryland School of Medicine, Greenebaum Comprehensive Cancer Center, Baltimore, Maryland

Alison Duffy, PharmD, BCOP Associate Professor, Department of Pharmacy Practice and Science, University of Maryland School of Pharmacy, Baltimore, Maryland

Ashkan Emadi, MD, PhD Professor, Medicine and Pharmacology; Associate Director for Clinical Research, Marlene and Stewart Greenebaum Comprehensive Cancer Center; Director, Translational Genomics Laboratory, University of Maryland School of Medicine, Baltimore, Maryland

Sonia Esparza, MD Hematology Oncology Fellow, University of North CarolinaChapel Hill, Chapel Hill, North Carolina

Amy Fulton, PhD Professor of Pathology, University of Maryland School of Medicine, Baltimore, Maryland

Gabriel Ghiaur, MD, PhD Assistant Professor of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland

Lukasz P. Gondek, MD, PhD Assistant Professor of Oncology and Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland

Arif Hussain, MD Professor of Medicine, University of Maryland School of Medicine, Baltimore, Maryland

S. Percy Ivy, MD Associate Chief, Investigational Drug Branch/CTEP/DCTD/NCI; Program Director, Experimental Therapeutics Clinical Trials Network, National Cancer Institute, Bethesda, Maryland

xvi Elizabeth Jaffee, MD Professor of Oncology and Deputy Director, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland

Judith E. Karp, MD Professor Emerita, Oncology and Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland

Scott H. Kaufmann, MD, PhD Professor of Pharmacology and Medicine, Division of Oncology Research, Mayo Clinic, Rochester, Minnesota

Mehmet Kocoglu, MD Assistant Professor, Department of Internal Medicine, Division of Hematology/Oncology, University of Maryland School of Medicine, Baltimore, Maryland

Mira A. Kohorst, MD Pediatrician, Division of Pediatric Hematology-Oncology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota

Justin Lawson, PharmD, BCOP Oncology Clinical Pharmacy Specialist Department of Pharmacy, University of Maryland Medical Center, Baltimore, Maryland

Ruby Leong, PharmD, BCOP Research Officer, U.S. Public Health Service, Division of Clinical Pharmacology V, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland

Richard F. Little, MD