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Sanjay Singh (editor) - Emerging Trends in Nanomedicine

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Sanjay Singh (editor) Emerging Trends in Nanomedicine

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This book illustrates the significance of nanotechnology in the delivery of anticancer and antimicrobial drugs, biomimetic technologies, tissue engineering, sensing, diagnostics, and artificial enzymes. It first briefly discusses the use of nanotechnology for the delivery of anticancer medications, and the concept and applications of catalytically active nanomaterial-based artificial enzymes for sensing and diagnostic applications. It then explores the use of silver nanoparticle-based novel antimicrobials, and comprehensively reviews the role of nanomaterials in developing biomedical implants and tissue engineering applications. Lastly, it offers a detailed description of nanotherapeutics for combating human protozoan parasitic infections. Cutting across the disciplines, this book serves as a guide for researchers and scientists in biotechnology, medical science and material science.

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Book cover of Emerging Trends in Nanomedicine Editor Sanjay Singh - photo 1
Book cover of Emerging Trends in Nanomedicine
Editor
Sanjay Singh
Emerging Trends in Nanomedicine
1st ed. 2021
Logo of the publisher Editor Sanjay Singh Nanomaterials and Toxicology - photo 2
Logo of the publisher
Editor
Sanjay Singh
Nanomaterials and Toxicology Lab, Division of Biological and Life Sciences, School of Arts and Sciences, Central Campus, Ahmedabad University, Ahmedabad, Gujarat, India
ISBN 978-981-15-9919-4 e-ISBN 978-981-15-9920-0
https://doi.org/10.1007/978-981-15-9920-0
Springer Nature Singapore Pte Ltd. 2021
This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.
The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd.

The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore

Contents
Ashok Kumar Jangid , Poonam Jain , Deep Pooja and Hitesh Kulhari
Priyanka Shinde , Hina F. Badgujar and Umesh Kumar
Nisha Yadav and Sanjay Singh
Shakil Ahmed Polash , Md. Monir Hossain , Tanushree Saha and Satya Ranjan Sarker
Unnati Modi , Dhaval Kedaria , Bindiya Dhimmar and Rajesh Vasita
Jobin Thomas , Sangeeta Yadav , Jitendra Satija and Shekhar Agnihotri
Riti Mehta and Souvik Sengupta
Sanjay Singh
List of Figures
List of Tables
About the Editor
Sanjay Singh

is currently an Associate Professor at the Division of Biological and Life Sciences, Ahmedabad University, Gujarat, India. After completing his Ph.D. at CSIR-National Chemical Laboratory, Pune, India, he continued his research as a postdoctoral fellow at the University of Central Florida and the Pennsylvania State University, USA. His research interests include the synthesis of novel anti-cancer drug formulations and nanomaterials with biological, enzyme-like characteristics. He has received numerous national and international awards, such as an Endeavour Research Fellowship, YY Memorial Award, International Association of Advanced Materials Scientists Medal, Ambassador Australian Awards, and an EMBO Fellowship.

Dr Singh has published over 80 papers in international, peer-reviewed journals and authored and co-authored several books and book chapters. He has also worked as a guest editor for various annual meetings of the Society for Redox Biology and Medicine (SfRBM) and the World Molecular Imaging Society (WMIS). He is the Associate Editor-in-Chief of 3 Biotech (Springer Nature), OncoTargets, and Therapy.

Springer Nature Singapore Pte Ltd. 2021
S. Singh (ed.) Emerging Trends in Nanomedicine https://doi.org/10.1007/978-981-15-9920-0_1
1. Introduction to Nanomedicines: Basic Concept and Applications
Ashok Kumar Jangid
(1)
School of Nano Sciences, Central University of Gujarat, Gandhinagar, Gujarat, India
(2)
The Centre for Advanced Materials & Industrial Chemistry, Applied Sciences, RMIT University, Melbourne, Australia
Hitesh Kulhari (Corresponding author)
Email:
Abstract

The application of nanotechnology in the medical field has grown significantly. Nanomaterials are being used for the diagnosis, prevention and treatment of diseases. This chapter is comprised of three sections. First section elaborates the concept and principle of nanomedicine. It also includes the advantages and disadvantages of nanomedicines. The second section discusses the applications of nanomaterials in bioimaging, drug delivery, nanozyme and biosensing. The last section is focused on the potential risks and challenges in the clinical translation of nanomedicines.

Keywords
Nanomedicine Applications of nanotechnology Potential risk and challenges
1.1 Basic Concept of Nanomedicine

Nanomedicine is an interdisciplinary science which involves the application of nanotechnology to health and medicine (Nezhadi et al. ).

When a therapeutic agent (drug or gene or other bioactive molecule) is encapsulated into a nanostructure, it is called nanomedicine. The development of a nanomedicine has several advantages over its conventional formulations (Guo et al. ). The specific advantages of nanomedicines could be listed as follows: Nanomedicines
  • Enhance the solubility, dissolution and bioavailability of the hydrophobic drugs.

  • Prevent premature degradation of encapsulated molecules.

  • Targeted nanomedicines enhance specificity of drugs towards diseased cells or tissue.

  • Improve transport across the biological barriers and cellular penetration.

  • Enhance therapeutic efficacy.

  • Decrease toxicity of drugs by decreasing unwanted interaction with biological system.

  • Provide opportunity to develop personalized medicines.

Various nanostructures like polymeric nanoparticles, lipid-based nanoparticles, metal or metal oxide-based nanostructures, dendrimers, and carbon-based nanostructures have deep explored for the development of nanomedicines (Afzal et al. ). Lipid-based formulation Doxil was the first nanomedicine, approved by FDA in 1996. It is a liposomal formulation of doxorubicin and used for the treatment of various cancers. After that, various nanoformulations have been developed and many are under clinical trials. Nanomedicines can be administered to the patient via almost every route of drug administration. The most commonly used routes for nanomedicines are oral, intravenous, intraperitoneal, transdermal, and nasal routes.

1.2 Applications of Nanotechnology in the Medical Field

The role of nanotechnology in various parts of medical field has been investigated. Different nanostructures have been used for bioimaging, drug and gene delivery, and as biosensors (Salata ). Metal or metal oxide-based nanostructures have also been explored for their nanozyme activities.

1.2.1 Bioimaging

Bioimaging means visualizing or obtaining the functional images of living biological systems and is widely used in biomedical field (Erathodiyil and Ying ).

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