Jonathan S. Berek MD MMS - Berek and Hacker’s Gynecologic Oncology

Sixth Edition

Jonathan S. Berek, MD, MMS

Laurie Kraus Lacob Professor

Director, Stanford Womens Cancer Center

Stanford Cancer Institute

Chair, Department of Obstetrics and Gynecology

Stanford University School of Medicine

Stanford, California

Neville F. Hacker, AM, MD

Professor of Gynaecologic Oncology

Conjoint, University of New South Wales

Director, Gynaecologic Cancer Centre

Royal Hospital for Women

Sydney, Australia

Illustrations and design by

Deborah Berek, MA

Tim Hengst, CMI, FAMI

Acquisitions Editor: Jamie M. Elfrank

Product Development Editor: Ashley Fischer

Editorial Assistant: Brian Convery

Production Project Manager: Bridgett Dougherty

Design Coordinator: Stephen Druding

Illustration Coordinator: Jennifer Clements

Manufacturing Coordinator: Beth Welsh

Marketing Manager: Stephanie Kindlick

Prepress Vendor: Aptara, Inc.

6th edition

Copyright 2015 Wolters Kluwer

Copyright 2010 Wolters Kluwer Health/Lippincott Williams & Wilkins. Copyright 2005 by Lippincott Williams & Wilkins. All rights reserved. This book is protected by copyright. No part of this book may be reproduced or transmitted in any form or by any means, including as photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. To request permission, please contact Wolters Kluwer at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at (products and services).

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Printed in China

Library of Congress Cataloging-in-Publication Data

Berek & Hackers gynecologic oncology / [edited by] Jonathan S. Berek, Neville F. Hacker; illustrations and design by Tim Hengst, George Barile, Deborah Berek. 6th edition.

p.; cm.

Berek and Hackers gynecologic oncology

Gynecologic oncology

Includes bibliographical references and index.

ISBN 978-1-4511-9007-6 (alk. paper)

I. Berek, Jonathan S., editor. II. Hacker, Neville F., editor. III. Title: Berek and Hackers gynecologic oncology. IV. Title: Gynecologic oncology.

[DNLM: 1. Genital Neoplasms, Female. 2. Genitalia, Femalephysiopathology. WP 145]

RC280.G5

616.99465dc23

2014032705

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This work is no substitute for individual patient assessment based upon healthcare professionals examination of each patient and consideration of, among other things, age, weight, gender, current or prior medical conditions, medication history, laboratory data and other factors unique to the patient. The publisher does not provide medical advice or guidance and this work is merely a reference tool. Healthcare professionals, and not the publisher, are solely responsible for the use of this work including all medical judgments and for any resulting diagnosis and treatments.

Given continuous, rapid advances in medical science and health information, independent professional verification of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options should be made and healthcare professionals should consult a variety of sources. When prescribing medication, healthcare professionals are advised to consult the product information sheet (the manufacturers package insert) accompanying each drug to verify, among other things, conditions of use, warnings and side effects and identify any changes in dosage schedule or contradictions, particularly if the medication to be administered is new, infrequently used or has a narrow therapeutic range. To the maximum extent permitted under applicable law, no responsibility is assumed by the publisher for any injury and/or damage to persons or property, as a matter of products liability, negligence law or otherwise, or from any reference to or use by any person of this work.

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To Deborah and Estelle, and to our patients, from whom we are always learning, and who continue to inspire us with their courage.