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Enrique Cadenas - Handbook of antioxidants

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This work examines authoritative coverage of the chemical, biological and clinical aspects of antioxidant molecules including particular antioxidant vitamins and other naturally occurring compounds such as melatonin. It discusses current avenues of antioxidant therapy, current research findings, and clinical trials on the protective role antioxidants play in preventing or minimizing free radical damage associated with cancer, cardiovascular disease, premature aging, cataracts, air pollution and strenuous exercise.

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title Handbook of Antioxidants Antioxidants in Health and Disease 3 - photo 1

title:Handbook of Antioxidants Antioxidants in Health and Disease ; 3
author:Cadenas, Enrique.
publisher:CRC Press
isbn10 | asin:082479298X
print isbn13:9780824792985
ebook isbn13:9780585157955
language:English
subjectAntioxidants--Handbooks, manuals, etc, Antioxidants--handbooks.
publication date:1996
lcc:RB170.H36 1996eb
ddc:612.3/9
subject:Antioxidants--Handbooks, manuals, etc, Antioxidants--handbooks.
Page aa
Handbook of Antioxidants
Page ab
ANTIOXIDANTS IN HEALTH AND DISEASE
Series Editors
LESTER PACKER, PH.D.
University of California
Berkeley, California
JRGENFUCHS, PH.D., M.D.
Johann Wolfgang Goethe University
Frankfurt, Germany
1. Vitamin A in Health and Disease, edited by Rune Blomhoff
2. Biothols in Health and Disease, edited by Lester Packer and Enrique Cadenas
3. Handbook of Antioxidants, edited by Enrique Cadenas and Lester Packer
Additional Volumes in Preparation
Vitamin C in Health and Disease, edited by Lester Packer and Jrgen Fuchs
Handbook of Synthetic Antioxidants, edited by Lester Packer and Jrgen Fuchs
Lipoic Acid in Health and Disease, edited by Jrgen Fuchs, Lester Packer, and Guido Zimmer
Related Volumes
Vitamin E in Health and Disease: Biochemistry and Clinical Applications, edited by Lester Packer and Jrgen Fuchs
Page i
Handbook of Antioxidants
Edited by
Enrique Cadenas
University of Southern California School of Pharmacy
Los Angeles, California
Lester Packer
University of California
Berkeley, California
Marcel Dekker, Inc.
New York Basel Hong Kong
Page ii
Library of Congress Cataloging-in-Publication Data
Handbook of antioxidants / [edited by] Enrique Cadenas, Lester Packer.
p. cm.(Antioxidants in health and disease ; 3)
Includes bibliographical references and index.
ISBN 0-8247-9298-X (hardcover : alk. paper)
1. AntioxidantsHandbooks, manuals, etc. I. Cadenas, Enrique.
II. Packer, Lester. III. Series.
[DNLM: 1. Antioxidantshandbooks. W1 AN884 v.3 1996 / QV 735 H235 1996]
RB170.H36 1996
612.3'9dc20
DNLM/DLC
for Library of Congress 95-47546
CIP
The publisher offers discounts on this book when ordered in bulk quantities. For more information, write to Special Sales/Professional Marketing at the address below.
This book is printed on acid-free paper.
Copyright 1996 by Marcel Dekker, Inc. All Rights Reserved.
Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage and retrieval system, without permission in writing from the publisher.
Marcel Dekker, Inc.
270 Madison Avenue, New York, New York 10016
Current printing (last digit):
10 9 8 7 6 5 4 3 2 1
PRINTED IN THE UNITED STATES OF AMERICA
Page iii
SERIES INTRODUCTION
In June of 1992, 17 international researchers in the field of free radical and antioxidant biology and preventive medicine met at the village of Saas Fee, Switzerland, and drew up the Saas Fee Declaration to recognize the importance of prevention in medicine and health. Since then, hundreds of researchers from around the world have signed the declaration:
Saas Fee Declaration
On the significance of antioxidants in preventive medicine.
1. The intensive research on free radicals of the past 15 years by scientists worldwide has led to the statement in 1992 that antioxidant nutrients may have major significance in the prevention of a number of diseases. These include cardiovascular and cerebrovascular disease, some forms of cancer and several other disorders, many of which may be age-related.
2. There is now general agreement that there is a need for further work at the fundamental scientific level, as well as in large-scale randomized trials and in clinical medicine, which can be expected to lead to more precise information being made available.
3. The major objective of this work is the prevention of disease. This may be achieved by use of antioxidants which are natural physiological
Page iv
substances. The strategy should be to achieve optimal intakes of these antioxidant nutrients as part of preventive medicine.
4. It is quite clear that many environmental sources of free radicals exist, such as ozone, sunlight, and other forms of radiation, smog, dust, and other atmospheric pollutants. The optimal intake of antioxidants provides a preventive measure against these hazards.
5. There is a great need for improvement in public awareness of the potential preventive benefits of antioxidant nutrient intake. There is overwhelming evidence that the antioxidant nutrients such as vitamin E, vitamin C, carotenoids, alpha-lipoic acid and others are safe even at very high levels of intake.
6. Moreover, there is now substantial agreement that governmental agencies, health professionals and the media should promote information transfer to the general public, particularly when evidence exists that benefits for human health and public expenditure are overwhelming.
This declaration arose from the overwhelming evidence now available indicating that antioxidants play a critical role in wellness, health maintenance, and the prevention of chronic and degenerative diseases. Antioxidants neutralize free radicals that are generated during normal metabolism and during exposure to environmental insult. Free radicals play a role in most major health problems of the industrialized world, including cardiovascular disease, cancer, and disorders of aging.
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