Lynne M. Coluccio - Myosins: A Superfamily of Molecular Motors

Advances in Experimental Medicine and Biologyprovides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields. provides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields.

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In the years since publication in 2008 ofMyosins: A Superfamily of Molecular Motors, considerable new strides have been made in understanding the structure and function of myosin motors. In particular, the application of advanced cell imaging approaches, the development of new animal models, the availability of new crystal structures, and the discovery of isoform-specific inhibitors have propelled the field forward. This volume addresses the current state of our collective knowledge regarding myosin structure and function. The chapters are written by internationally recognized experts in molecular motors. It is a testament to the importance of this endeavor that authors of chapters in the 2008 volume who were asked to contribute to this new volume all enthusiastically agreed. In addition, new authors were effortlessly recruited to cover new areas including the more recently discovered myosins XVI, XVIII, and XIX, myosin inhibitors, and the structural basis for cargo binding. The hope is that this volume will serve as a reference for both investigators and students and stimulate new research on this amazing family of motor molecules. I am sincerely grateful to the contributors who made this volume possible. It has been my privilege and pleasure to work with each of them. I would also like to thank Gonzalo Cordova from Springer Nature BV, Dordrecht, for the opportunity to edit this book. The careful editing by Springer staff members is greatly appreciated.