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Book:
Non-coding RNAs in Cardiovascular Diseases
Author:
Junjie Xiao
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Springer Singapore
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2020
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Volume 1229

Advances in Experimental Medicine and Biology

Series Editors

Wim E. Crusio

Institut de Neurosciences Cognitives et Intgratives dAquitaine, CNRS and University of Bordeaux UMR 5287, Pessac Cedex, France

Heinfried H. Radeke

Institute of Pharmacology & Toxicology, Clinic of the Goethe University Frankfurt Main, Frankfurt am Main, Germany

Nima Rezaei

Research Center for Immunodeficiencies, Childrens Medical Center, Tehran University of Medical Sciences, Tehran, Iran

Advances in Experimental Medicine and Biologyprovides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields.

Advances in Experimental Medicine and Biologyhas been publishing exceptional works in the field for over 40 years, and is indexed in SCOPUS, Medline (PubMed), Journal Citation Reports/Science Edition, Science Citation Index Expanded (SciSearch, Web of Science), EMBASE, BIOSIS, Reaxys, EMBiology, the Chemical Abstracts Service (CAS), and Pathway Studio.

2018 Impact Factor: 2.126.

More information about this series at http://www.springer.com/series/5584

Editor

Junjie Xiao

Non-coding RNAs in Cardiovascular Diseases

Editor

Junjie Xiao

Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai, China

ISSN 0065-2598 e-ISSN 2214-8019

Advances in Experimental Medicine and Biology

ISBN 978-981-15-1670-2 e-ISBN 978-981-15-1671-9

https://doi.org/10.1007/978-981-15-1671-9

Springer Nature Singapore Pte Ltd. 2020

This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed.

The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.

The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd.

The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore

Contents

Part IOverview

Iram Mushtaq , Ayesha Ishtiaq , Tahir Ali , Muhammad Ishtiaq Jan and Iram Murtaza

Part IIBioinformatics and Interactions

Marina C. Costa , Andr F. Gabriel and Francisco J. Enguita

Rui Chen , Chao Shi , Jianhua Yao and Wei Chen

Andr F. Gabriel , Marina C. Costa and Francisco J. Enguita

Parveen Bansal and Malika Arora

Part IIINon-coding RNAs Regulation in Cardiovascular System

Swati Sharma , Aastha Mishra and Mohammad Zahid Ashraf

Wanlin Jiang , Devendra K. Agrawal and Chandra Shekhar Boosani

Lijun Wang , Jiaqi Wang , Guoping Li and Junjie Xiao

C. F. T. van der Ven , B. C. R. Hogewoning , A. van Mil and Joost P. G. Sluijter

Lu Xia and Meiyi Song

Enrico Pozzo , Yoke Chin Chai and Maurilio Sampaolesi

Part IVNon-coding RNAs and Cardiovascular Diseases

Bihui Luo , Xiaojun Zeng , Peiying Liu and Hua Zhu

Jianfeng He , Yanhong Luo , Junxia Song , Tao Tan and Hua Zhu

Cuimei Zhao , Guoping Li and Jin Li

Tarik Smani , Isabel Mayoral-Gonzalez , Isabel Galeano-Otero , Isabel Gallardo-Castillo , Juan A. Rosado , Antonio Ordoez and Abdelkrim Hmadcha

Alejandro Cardona-Monzons , Jos Luis Garca-Gimnez , Salvador Mena-Moll , Helios Pareja-Galeano , Fernando de la Gua-Galipienso , Giuseppe Lippi , Federico V. Pallard and Fabian Sanchis-Gomar

Filip ustr , Zdenk Strek , Miroslav Souek and Jan Novk

Jan A. Kleeberger , Philipp J. Tomsits , Stefan Kb and Sebastian Clauss

Diego Franco , Amelia Aranega and Jorge N. Dominguez

Nedyalka Valkov and Saumya Das

Jenny Y. Y. Ooi and Bianca C. Bernardo

Part VPotential Biomarkers and Therapeutic Implications

Chenglin Zhao , Yicheng Lv , Yi Duan , Guoping Li and Zhongrong Zhang

Parveen Bansal and Malika Arora

Part VIFuture Prospects

Muhammad Ishtiaq Jan , Tahir Ali , Ayesha Ishtiaq , Iram Mushtaq and Iram Murtaza

Part I Overview

Springer Nature Singapore Pte Ltd. 2020

J. Xiao (ed.) Non-coding RNAs in Cardiovascular Diseases Advances in Experimental Medicine and Biology 1229 https://doi.org/10.1007/978-981-15-1671-9_1

1. An Overview of Non-coding RNAs and Cardiovascular System

Iram Mushtaq

(1)

Department of Biochemistry, Signal Transduction Laboratory, Faculty of Biological Sciences, Quaid-i-Azam University Islamabad, Islamabad, Pakistan

Iram Murtaza

Email:

Abstract

Cardiovascular disease management and timely diagnosis remain a major dilemma. Delineating molecular mechanisms of cardiovascular diseases is opening horizon in the field of molecular medicines and in the development of early diagnostic markers. Non-coding RNAs are the highly functional and vibrant nucleic acids and are known to be involved in the regulation of endothelial cells, vascular and smooth muscles cells, cardiac metabolism, ischemia, inflammation and many processes in cardiovascular system. This chapter is comprehensively focusing on the overview of the non-coding RNAs including their discovery, generation, classification and functional regulation. In addition, overview regarding different non-coding RNAs as long non-coding, siRNAs and miRNAs involvement in the cardiovascular diseases is also addressed. Detailed functional analysis of this vast group of highly regulatory molecules will be promising for shaping future drug discoveries.

Keywords

Non-coding RNA Cardiovascular diseases Molecular medicines Biomarker

Background

Non-coding RNA (ncRNA) can be defined according to their operational length of transcripts []. They can be divided into Short non-coding RNA and Long non-coding RNA.

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