Valdir Cechinel-Filho - Plant Bioactives and Drug Discovery

Wiley Series in Drug Discovery and Development

Binghe Wang, Series Editor

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Drug Transporters: Molecular Characterization and Role in Drug Disposition
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Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery
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Edited by Albert P. Li

Dopamine Transporters: Chemistry, Biology, and Pharmacology
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ABC Transporters and Multidrug Resistance
Edited by Ahcene Boumendjel, Jean Boutonnat, and Jacques Robert

Kinase Inhibitor Drugs
Edited by Rongshi Li and Jeffrey A. Stafford

Evaluation of Drug Candidates for Preclinical Development: Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology
Edited by Chao Han, Charles B. Davis, and Binghe Wang

HIV-1 Integrase: Mechanism and Inhibitor Design
Edited by Nouri Neamati

Carbohydrate Recognition: Biological Problems, Methods, and Applications
Edited by Binghe Wang and Geert-Jan Boons

Chemosensors: Principles, Strategies, and Applications
Edited by Binghe Wang and Eric V. Anslyn

Medicinal Chemistry of Nucleic Acids
Edited by Li He Zhang, Zhen Xi, and Jyoti Chattopadhyaya

Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications
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Dendrimer-Based Drug Delivery Systems: From Theory to Practice
Edited by Yiyun Cheng

Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives
Edited by Valdir Cechinel-Filho

Copyright 2012 by John Wiley & Sons, Inc. All rights reserved

Published by John Wiley & Sons, Inc., Hoboken, New Jersey

Published simultaneously in Canada

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Library of Congress Cataloging-in-Publication Data:

Plant bioactives and drug discovery: principles, practice, and perspectives / edited by Valdir Cechinel-Filho.

p. ; cm. (Wiley series in drug discovery and development)

Includes bibliographical references and index.

ISBN 978-0-470-58226-8 (cloth)

I. Cechinel-Filho, Valdir. II. Series: Wiley series in drug discovery and development.

[DNLM: 1. Plants, Medicinalmetabolism. 2. Drug Discovery. 3. Plant Extractspharmacology. QV 766]

615.321dc23

2011041434

Contributors

A. Douglas Kinghorn , Division of Medicinal Chemistry and Pharmacognosy, The Ohio State University, Columbus, OH, USA

Alan L. Harvey , University of Strathclyde, Glasgow, UK

Alberto Boffi , Sapienza Universit di Roma, Rome, Italy

Alberto Macone , Sapienza Universit di Roma, Rome, Italy

Alessandra Bonamore , Sapienza Universit di Roma, Rome, Italy

Andrea Calcaterra , Sapienza Universit di Roma, Rome, Italy

Anglica G. Couto , Universidade do Vale do Itaja (UNIVALI), Itaja-SC-Brazil

Arturo San Feliciano , Department of Pharmaceutical Chemistry, University of Salamanca, Salamanca, Spain

Bruno Botta , Sapienza Universit di Roma, Rome, Italy

Carlos A. M. Fraga , Faculty of Pharmacy, Universidade Federal do Rio de Janeiro Rio de Janeiro, RJ, Brazil

Chung Ki Sung , Division of Medicinal Chemistry and Pharmacognosy, The Ohio State University, Columbus, OH, USA

David G. I. Kingston , Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA

David J. Newman , National Cancer Institute-Frederick, Frederick, MD, USA

Dayana R. Gouveia , Departamento de Fsica e Qumica, Universidade de So Paulo, (USP), Ribeiro Preto SP, Brazil

Eliezer J. Barreiro , Faculty of Pharmacy, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil

Elisaldo A. Carlini , Universidade Federal de So Paulo (UNIFESP), So Paulo, Brazil

Elisa Petenatti , National University of San Luis, Argentina

Emerson F. Queiroz , University of Geneva and University of Lausanne, Switzerland

Esther del Olmo , Department of Pharmaceutical Chemistry, University of Salamanca, Salamanca, Spain

Francesca Ghirga , Sapienza Universit di Roma, Rome, Italy

Flvio R. Mendes Gina Negri , Universidade Federal de So Paulo (UNIFESP), So Paulo, Brazil

Giuliano Delle Monache , Sapienza Universit di Roma, Rome, Italy

Gordon M. Cragg , National Cancer Institute-Frederick, Frederick, MD, USA

Ilaria D'Acquarica , Sapienza Universit di Roma, Rome, Italy

James D. McChesney , Ironstone Separations, Inc., Etta, MS, USA

Jean-Luc Wolfender , University of Geneva and University of Lausanne, Switzerland

Jie Li , Division of Medicinal Chemistry and Pharmacognosy, The Ohio State University, Columbus, OH, USA

Jielu Zhao , Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA

Joaquim M. Duarte-Almeida , Universidade Federal de So Paulo (UNIFESP), So Paulo, Brazil

Jos L. Lpez-Prez , Department of Pharmaceutical Chemistry, University of Salamanca, Salamanca, Spain

Jos R. Santin , Chemical-Pharmaceutical Investigations Center (NIQFAR), Universidade do Vale do Itaja (UNIVALI), Itaja-SC, Brazil

Jun Qi , Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA