J. Larry Jameson MD PhD - Endocrinology, 6th Edition, 2-Volume Set: Adult and Pediatric, Expert Consult Premium Edition

Endocrinology

Adult and Pediatric

Sixth Edition

J. Larry Jameson, MD, PhD

Professor of Medicine, Dean, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, Illinois

Leslie J. De Groot, MD

Research Professor, Cellular and Life Sciences, University of Rhode Island, Providence Campus, Providence, Rhode Island

Saunders

Front Matter

Copyright

1600 John F. Kennedy Blvd.

Ste 1800

Philadelphia, PA 19103-2899

Endocrinology Part number: 9-9960-7447-1 (vol 1)

Part number: 9-9960-7441-2 (vol 2)

ISBN: 978-1-4160-5583-9 (set)

Copyright 2010, 2006, 2001, 1995, 1989, 1979 by Saunders, an affiliate of Elsevier Inc.

.

Notice

Knowledge and best practice in this field are constantly changing. As new research and experience broaden our knowledge, changes in practice, treatment, and drug therapy may become necessary or appropriate. Readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of the practitioner, relying on their own experience and knowledge of the patient, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions. To the fullest extent of the law, neither the Publisher nor the Authors assumes any liability for any injury and/or damage to persons or property arising out of or related to any use of the material contained in this book.

The Publisher

Library of Congress Cataloging-in-Publication Data

Endocrinology / senior editors, Leslie J. De Groot, J. Larry Jameson ; section editors, Ashley Grossman [et al.].6th ed.

p. ; cm.

Includes bibliographical references and index.

ISBN-13: 978-1-4160-5583-9 (v.1 & v.2 : hardback : alk. paper)

ISBN-13: 978-9996074479 (v.1 : hardback : alk. paper)

ISBN-10: 9996074471 (v.1 : hardback : alk. paper)

ISBN-13: 978-9996074417 (v.2 : hardback : alk. paper)

[etc.]

1. Endocrine glandsDiseases. 2. Endocrinology. I. De Groot, Leslie J. II. Jameson, J. Larry.

[DNLM: 1. Endocrine System Diseases. 2. Endocrine Glands. 3. Hormones. WK 140 E5585 2010]

RC648.E458 2010

616.4dc22

2010001335

Acquisitions Editor: Pamela Hetherington

Developmental Editor: Mary Beth Murphy

Publishing Services Manager: Catherine Jackson

Senior Project Manager: Rachel E. McMullen

Design Direction: Ellen Zanolle

Printed in China

Last digit is the print number: 9 8 7 6 5 4 3 2 1

Contributors

Lloyd Paul Aiello, MD, PhD, Director, Beetham Eye Institute, Joslin Diabetes Center
Associate Professor of Ophthalmology, Harvard Medical School
Department of Ophthalmology, Harvard Medical School
Joslin Diabetes Center
Boston, Massachusetts

Erik K. Alexander, MD, Assistant Professor of Medicine
Department of Medicine
Brigham & Womens Hospital/Harvard Medical School
Boston, Massachusetts

Carolyn A. Allan, MBBS(Hons), PhD, DRCOG(UK), FRACP, Postdoctoral Research Fellow
Prince Henrys Institute;
Honorary Senior Lecturer
Department of Obstetrics and Gynaecology
Monash University;
Endocrinologist
Monash Medical Centre
Clayton, Victoria, Australia

Bruno Allolio, MD, Professor of Medicine
Deptartment of Endocrinology and Diabetes
Med. Univ. Hospital
University of Wuerzburg
Wuerzburg, Germany

Peter Angelos, MD, PhD, FACS, Professor and Chief of Endocrine Surgery
The University of Chicago
Chicago, Illinois

Sree Appu, Department of Surgery, Monash University
Consultant Urologist
Monash Medical Centre
Melbourne, Australia

Richard J. Auchus, MD, PhD, The Charles A. and Elizabeth Ann Sanders Chair in Translational Research and Professor
Internal Medicine, Division of Endocrinology and Metabolism
The University of Texas Southwestern Medical Center at Dallas
Dallas, Texas

Joseph Avruch, MC, Professor of Medicine
Harvard Medical School;
Physician and Chief
Diabetes Unit
Member
Department of Molecular Biology
Massachusetts General Hospital
Boston, Massachusetts

Lloyd Axelrod, MD, Associate Professor of Medicine
Department of Medicine
Harvard Medical School;
Physician and Chief of the James Howard Means Firm Medical Services
Massachusetts General Hospital
Boston, Massachusetts

Rebecca S. Bahn, MD, Professor of Medicine
Endocrinology, Diabetes, Metabolism and Nutrition
Mayo Clinic
Rochester, Minnesota

H.W.G. Baker, MD, PhD, FRACP, Professor
University of Melbourne Department of Obstetrics and Gynaecology
The Royal Womens Hospital
Victoria, Australia

Randall B. Barnes, MD, Associate Professor
Obstetrics and Gynecology
Northwestern University, Feinberg School of Medicine
Chicago, Illinois

Murat Bastepe, MD, PhD, Assistant Professor of Medicine
Endocrine Unit, Department of Medicine
Massachusetts General Hospital and Harvard Medical School