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Will Cole - Intuitive fasting : the flexible four-week intermittent fasting plan to recharge your metabolism and renew your health

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Will Cole Intuitive fasting : the flexible four-week intermittent fasting plan to recharge your metabolism and renew your health
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Acknowledgments

Amber, Solomon, and Shiloh: I love you so freaking much. Thank you for being my center and my safe place.

My team: Andrea, Yvette, Emily, Janice, Megan, Brinna, Hollie, and Maddy: You are part of my family and my closest friends. Thank you for your consistent devotion, diligence, and compassion for our patients and for one another.

My patients around the world: Thank you for letting me be a part of your sacred journey into wellness. I do not take that responsibility lightly. Serving you is truly an honor.

Heather, Diana, Michele, and everyone at Rodale and Waterbury: You are the best team I could have dreamed of. Thank you for always listening to my vision and doing everything to help it come to life.

Gretchen: Thank you for your friendship and putting your heart into this book with me.

Gwyneth, Elise, Kiki, and my goop family: I am immensely grateful for you. Thank you for your years of friendship and for championing me.

Dr. Alejandro Junger, Melissa Urban, Dr. Terry Wahls, and Dr. Josh Axe: Thank you for being my mentors, heroes, and good friends in this space of wellness.

Finally, thank you to everyone in the functional medicine and wellness world: Continue being a light.

About the Author

DR. WILL COLE, IFMCP, DNM, DC, is a leading functional medicine expert who consults with people around the world via webcam at www.drwillcole.com and locally in Pittsburgh, Pennsylvania. Named one of the top fifty functional-medicine and integrative doctors in the nation, Dr. Cole specializes in clinically investigating underlying factors of chronic disease and customizing a functional medicine approach for thyroid issues, autoimmune conditions, hormonal imbalances, digestive disorder, and brain problems. He is the bestselling author of Ketotarian and The Inflammation Spectrum. Dr. Cole also hosts the popular podcasts goopfellas and The Art of Being Well. You can find him on Instagram at Instagram.com/drwillcole or on Facebook at facebook.com/doctorwillcole.

Notes

Chapter 1

Byrne NM, Sainsbury A, King NA, et al. Intermittent energy restriction improves weight loss efficiency in obese men; the matador study. Int J Obes (Lond). 2018;42(2):129138. doi:10.1038/ijo.2017.206.

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Carter S, Clifton PM, Keogh JB. The effects of intermittent compared to continuous energy restriction on glycaemic control in type 2 diabetes: a pragmatic pilot trial. Diabetes Res Clin Pract. 2016;122:106112. doi:10.1016/j.diabres.2016.10.010.

Kahleova H, Belinova L, Malinska H, et al. Eating two larger meals a day (breakfast and lunch) is more effective than six smaller meals in a reduced-energy regimen for patients with type 2 diabetes: a randomised crossover study [published correction appears in Diabetologia. 2015 Jan;58(1):205]. Diabetologia. 2014;57(8):15521560. doi:10.1007/s00125-014-3253-5.

Chapelot D. The role of snacking in energy balance: a biobehavioral approach. J Nutr. 2011;141(1):158162. doi:10.3945/jn.109.114330.

Ribeiro AG, Costa MJ, Faintuch J, Dias MC. A higher meal frequency may be associated with diminished weight loss after bariatric surgery. Clinics (Sao Paulo). 2009;64(11):10531058. doi:10.1590/S1807-59322009001100004.

Fildes A, Charlton J, Rudisill C, et al. Probability of an obese person attaining normal body weight: cohort study using electronic health records. Am J Public Health. 2015;105(9):e54e59. doi:10.2105/AJPH.2015.302773.

risk markers: a randomized trial in young overweight women. Int J Obes (Lond). 2011;35(5):714727. doi:10.1038/ijo.2010.171.

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Penny F. Notes on a thirty days fast. Br Med. 1909 Jun;1(2528):141416. doi: 10.1136/bmj.1.2528.1414.

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Hartman AL, Rubenstein JE, Kossoff EH. Intermittent fasting: a new historical strategy for controlling seizures? Epilepsy Res. 2013;104(3):275279. doi:10.1016/j.eplepsyres.2012.10.011.

Cordain L, Eaton SB, Sebastian A, et al. Origins and evolution of the western diet: health implications for the 21st century. Am J Clin Nut. 2005;81(2):34154. doi:10.1093/ajcn.81.2.341.

Mattson MP. An evolutionary perspective on why food overconsumption impairs cognition. Trends Cogn Sci. 2019;23(3):20012. doi:10.1016/j.tics.2019.01.003.

Chapter 2

Kallus SJ, Brandt LJ. The intestinal microbiota and obesity. J Clin Gastroenterol. 2012;46(1):1624. doi:10.1097/MCG.0b013e31823711fd.

Suez J, Korem T, Zeevi D, et al. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature. 2014;514(7521):181186. doi:10.1038/nature13793.

Wang H, Lu Y, Yan Y, et al. Promising treatment for type 2 diabetes: fecal microbiota transplantation reverses insulin resistance and impaired islets. Front Cell Infect Microbiol. 2020;9:455. Published 2020 Jan 17. doi:10.3389/fcimb.2019.00455.

Alcock J, Maley CC, Aktipis CA. Is eating behavior manipulated by the gastrointestinal microbiota? Evolutionary pressures and potential mechanisms. Bioessays. 2014;36(10):94049. doi:10.1002/bies.201400071.

Rousseaux C, Thuru X, Gelot A, et al. Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors. Nat Med. 2007;13(1):357. doi:10.1038/nm1521.

Perry RJ, Wang Y, Cline GW, et al. Leptin mediates a glucosefatty acid cycle to maintain glucose homeostasis in starvation. Cell. 2018;172(12):234248.e17. doi:10.1016/j.cell.2017.12.001.

Zhou Y, Rui L. Leptin signaling and leptin resistance. Front Med. 2013;7(2):20722. doi:10.1007/s11684-013-0263-5.

Chetty S, Friedman AR, Taravosh-Lahn K, et al. Stress and glucocorticoids promote oligodendrogenesis in the adult hippocampus. Mol Psychiatry. 2014;19(12):127583. doi:10.1038/mp.2013.190.

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Pillai V, Roth T, Mullins HM, Drake CL. Moderators and mediators of the relationship between stress and insomnia: stressor chronicity, cognitive intrusion, and coping. Sleep. 2014;37(7):11991208. Published 2014 Jul 1. doi:10.5665/sleep.3838.

Wang HX, Wahlberg M, Karp A, et al. Psychosocial stress at work is associated with increased dementia risk in late life. Alzheimers Dement. 2012;8(2):11420. doi:10.1016/j.jalz.2011.03.001.

Sinha R, Jastreboff AM. Stress as a common risk factor for obesity and addiction. Biol Psychiatry. 2013;73(9):827835. doi:10.1016/j.biopsych.2013.01.032.

Konturek PC, Brzozowski T, Konturek SJ. Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options. J Physiol Pharmacol. 2011;62(6):59199.

Cohen S, Janicki-Deverts D, Doyle WJ, et al. Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proc Natl Acad Sci USA. 2012;109(16):599599. doi:10.1073/pnas.1118355109.

Burcelin R, Garidou L, Pomi C. Immuno-microbiota cross and talk: the new paradigm of metabolic diseases. Semin Immunol. 2012;24(1):6774. doi:10.1016/j.smim.2011.11.011.

Ohman MK, Wright AP, Wickenheiser KJ, et al. Visceral adipose tissue and atherosclerosis. Curr Vasc Pharmacol. 2009;7(2):169179. doi:10.217 4/157016109787455680 .

Jung SH, Ha KH, Kim DJ. Visceral fat mass has stronger associations with diabetes and prediabetes than other anthropometric obesity indicators among Korean adults. Yonsei Med J. 2016;57(3):674680. doi:10.3349/ymj.2016.57.3.674.

Chapter 3

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de Cabo R, Mattson MP. Effects of intermittent fasting on health, aging, and disease [published correction appears in N Engl J Med. 2020 Jan 16;382(3):298] [published correction appears in N Engl J Med. 2020 Mar 5;382(10):978]. N Engl J Med. 2019;381(26):254151. doi:10.1056/NEJMra1905136.

de Cabo R, Mattson MP. Effects of intermittent fasting on health, aging, and disease [published correction appears in N Engl J Med. 2020 Jan 16;382(3):298] [published correction appears in N Engl J Med. 2020 Mar 5;382(10):978]. N Engl J Med. 2019;381(26):254151. doi:10.1056/NEJMra1905136.

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