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Larry Squire - Fundamental Neuroscience, Fourth Edition

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Larry Squire Fundamental Neuroscience, Fourth Edition

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The fourth edition of Fundamental Neuroscience reinvents itself as an engrossing and comprehensive presentation of the discipline of neuroscience, from molecules to cognition. Thorough but succinct, and lavishly illustrated, the book builds from an introductory section that includes fundamental neuroanatomy and goes on to cover cellular and molecular neuroscience, development, sensory systems, motor systems, regulatory systems, and behavioral and cognitive neuroscience. The book has been retooled to better serve its audience in the neuroscience and medical communities.

The chapters include more than 100 boxes describing clinical conditions, techniques, and other special topics. Each chapter went through a thorough review process, giving the book an evenness of tone. The chapters are authored by outstanding working scientists who are experts on the topics they cover.

  • Selected for inclusion in Doodys Core Titles 2013, an essential collection development tool for health sciences libraries
  • 30% new material including new chapters on dendritic development and spine morphogenesis, chemical senses, cerebellum, eye movements, circadian timing, sleep and dreaming, and consciousness
  • Accompanying website for students and instructors
  • Additional text boxes describing key experiments, disorders, methods, and concepts
  • More than 650 four-color illustrations, micrographs, and neuroimages
  • Multiple model system coverage beyond rats, mice, and monkeys
  • Extensively expanded index for easier referencing

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Fundamental Neuroscience Fourth Edition Edited by Larry R Squire VA - photo 1
Fundamental Neuroscience

Fourth Edition

Edited by

Larry R. Squire

VA Medical Center San Diego, California, University of California, San Diego, La Jolla, California

Darwin Berg

University of California, San Diego, La Jolla, California

Floyd E. Bloom

The Scripps Research Institute, La Jolla, California

Sascha du Lac

The Salk Institute, La Jolla, California

Anirvan Ghosh

University of California, San Diego, La Jolla, California

Nicholas C. Spitzer

University of California, San Diego, La Jolla, California

Table of Contents Copyright Academic Press is an imprint of Elsevier 225 - photo 2

Table of Contents
Copyright

Academic Press is an imprint of Elsevier

225 Wyman Street, Waltham, MA 02451, USA

The Boulevard, Langford Lane, Kidlington, Oxford, OX5 1GB, UK

2013 Elsevier Inc. All rights reserved.

No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the Publisher. Details on how to seek permission, further information about the Publishers permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions .

This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein).

Notices

Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary.

Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility.

To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein.

Library of Congress Cataloging-in-Publication Data

Fundamental neuroscience / edited by Larry Squire [et al.]. 4th ed.

p. cm.

Includes bibliographical references and index.

ISBN 978-0-12-385870-2 (alk. paper)

1. Neurosciences. I. Squire, Larry R.

QP355.2.F862 2012

612.8dc23

2012020285

British Library Cataloguing-in-Publication Data

A catalogue record for this book is available from the British Library.

Cover Image: The confocal image shows dopaminergic (green) and GABAergic (red) neurons in the developing Xenopus accessory olfactory bulb that mediate kinship recognition among siblings. The number of dopaminergic and GABAergic neurons changes in response to sustained exposure to olfactory stimuli. Courtesy of Davide Dulcis and Nicholas Spitzer.

For information on all Academic Press publications visit our website: http://store.elsevier.com

Printed in China

12 13 14 15 16 10 9 8 7 6 5 4 3 2 1

List of Boxes Preface to the Fourth Edition In this fourth edition of - photo 3

List of Boxes
Preface to the Fourth Edition

In this fourth edition of Fundamental Neuroscience, we have tried to improve on the third edition with a volume that effectively introduces students to the full range of contemporary neuroscience. Neuroscience is a large field founded on the premise that all of behavior and all of mental life have their origin in the structure and function of the nervous system. Today, the need for a single-volume introduction to neuroscience is greater than ever. Toward the end of the twentieth century, the study of the brain moved from a peripheral position within both the biological and psychological sciences to become an interdisciplinary field that is now central within each discipline. The maturation of neuroscience has meant that individuals from diverse backgroundsincluding molecular biologists, computer scientists, and psychologistsare interested in learning about the structure and function of the brain and about how the brain works. In addition, new techniques and tools have become available to study the brain in increasing detail. New genetic methods have been introduced to delete or overexpress single genes with spatial and temporal specificity. Neuroimaging techniques such as functional magnetic resonance imaging (fMRI) have been developed that allow study of the living human brain while it is engaged in cognition.

This fourth edition attempts to capture the promise and excitement of this fast-moving discipline. All the chapters have been rewritten and updated. The volume begins with an opening chapter that provides an overview of the discipline. A second chapter presents fundamental information about the architecture and anatomy of nervous systems. The remainder of the volume (Sections IIVII) presents the major topics of neuroscience. The second section (Cellular and Molecular Neuroscience) considers the cellular and subcellular organization of neurons, the physiology of nerve cells, and how signaling occurs between neurons. The third section (Nervous System Development) includes discussion of neural induction, cell fate, migration, pathfinding, synapse formation, programmed cell death, synapse elimination, development of dendrites, and early experience, including critical periods. The fourth and fifth sections (Sensory Systems and Motor Systems) describe the neural organization of each sensory modality and the organization of the brain pathways and systems important for locomotion, voluntary action, and eye movements. The sixth section (Regulatory Systems) describes the variety of hypothalamic and extra-hypothalamic systems that support motivation, reward, and internal regulation, including respiration, food and water intake, neuroendocrine function, circadian rhythms, and sleep and dreaming. The final section (Behavioral and Cognitive Neuroscience) describes the neural foundations of the so-called higher mental functions, including perception, attention, memory, language, spatial cognition, and executive function. Additional chapters cover human brain evolution, cognitive development and aging, and consciousness. The chapters contain more than 100 Boxes that describe clinical conditions, techniques, and special topics related to chapter content. The volume is also accompanied by companion websites for students and instructors, which present all the Figures and Boxes. In addition, the instructors website includes sample test questions for each chapter that draw attention to the key facts and concepts in the chapters.

The authors of the chapters and boxes are working scientists, experts in the topics they cover. The Editors edited the chapters to achieve consistency of style and content. At Academic Press/Elsevier Science, the project was coordinated by Mica Haley (Acquisitions Editor), and we are grateful to her for her leadership and advice throughout the project. In addition, April Graham (Editorial Project Manager) very capably and efficiently supervised the development of the book, and Lisa Lamenzo (Project Manager) expertly coordinated its production.

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