Shailza Singh - Metagenomic Systems Biology: Integrative Analysis of the Microbiome
Here you can read online Shailza Singh - Metagenomic Systems Biology: Integrative Analysis of the Microbiome full text of the book (entire story) in english for free. Download pdf and epub, get meaning, cover and reviews about this ebook. City: Singapore, year: 2021, publisher: Springer Singapore, genre: Science. Description of the work, (preface) as well as reviews are available. Best literature library LitArk.com created for fans of good reading and offers a wide selection of genres:
Romance novel
Science fiction
Adventure
Detective
Science
History
Home and family
Prose
Art
Politics
Computer
Non-fiction
Religion
Business
Children
Humor
Choose a favorite category and find really read worthwhile books. Enjoy immersion in the world of imagination, feel the emotions of the characters or learn something new for yourself, make an fascinating discovery.
- Book:Metagenomic Systems Biology: Integrative Analysis of the Microbiome
- Author:
- Publisher:Springer Singapore
- Genre:
- Year:2021
- City:Singapore
- Rating:5 / 5
- Favourites:Add to favourites
- Your mark:
Metagenomic Systems Biology: Integrative Analysis of the Microbiome: summary, description and annotation
We offer to read an annotation, description, summary or preface (depends on what the author of the book "Metagenomic Systems Biology: Integrative Analysis of the Microbiome" wrote himself). If you haven't found the necessary information about the book — write in the comments, we will try to find it.
The book serves as an amalgamation of knowledge and principles used in the area of systems and synthetic biology, and targets inter-disciplinary research groups. The readers from diversified areas would be benefited by the valuable resources and information available in one book. Microbiome projects with efficient data handling can fuel progress in the area of microbial synthetic biology by providing a ready to use plug and play chassis. Advances in gene editing technology such as the use of tailor made synthetic transcription factors will further enhance the availability of synthetic devices to be applied in the fields of environment, agriculture and health. The different chapters of the book reviews a broad range of topics, including food microbiome in ecology, use of microbiome in personalized medicine, machine learning in biomedicine. The book also describes ways to harness and exploit the incredible amounts of genomic data.
The book is not only limited to medicine but also caters to the needs of environmentalists, biochemical engineers etc. It will be of interest to advanced students and researchers in life sciences, computational biology, microbiology and other inter-disciplinary areas.
Shailza Singh: author's other books
Who wrote Metagenomic Systems Biology: Integrative Analysis of the Microbiome? Find out the surname, the name of the author of the book and a list of all author's works by series.
Metagenomic Systems Biology: Integrative Analysis of the Microbiome — read online for free the complete book (whole text) full work
Below is the text of the book, divided by pages. System saving the place of the last page read, allows you to conveniently read the book "Metagenomic Systems Biology: Integrative Analysis of the Microbiome" online for free, without having to search again every time where you left off. Put a bookmark, and you can go to the page where you finished reading at any time.
Font size:
Interval:
Bookmark:
This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd.
The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
is Scientist E and In-Charge of Bioinformatics and High Performance Computing Facility at National Centre for Cell Science, Pune. Her lab focuses on systems and synthetic biology of infectious disease leishmaniasis, wherein she is trying to integrate the action of regulatory circuits, cross talk between pathways and non-linear kinetics of biochemical processes through mathematical modeling. The hypotheses laid down through theoretical approaches are validated in in vitro and in vivo systems. Currently, she has started working in the area of Precision Oncology.
She is the recipient of several awards such as RGYI, DST-Young Scientist, INSA Bilateral Exchange, SAKURA Exchange Program etc. She is the reviewer of various international journals of repute like Scientific Reports, PlosOne, Molecular Biosystems, Oncotarget, BMC Systems Biology, Parasites and Vectors, ACS Journal of Natural products etc. She also serves as reviewers for various national and international grants like DST, DBT, CSIR, RCUK etc. She has guided a number of MTech, MSc. and PhD students.
Gut microbiota with diverse population has gained a lot of attention in the last decade. This microbial population along with maintaining homeostasis in gut also shapes the immune system in gut by interacting with various arms of the immune system. It has an important role in development of gut-associated lymphoid tissues (GALTs), regulating the Th17 cells development by intrinsic mechanism along with their importance in differentiation of Th17 cells in lamina propria. It has also been observed that host-intestinal T cell mutualism is also maintained by Treg-cell response generated due to microbial colonization. Along with this, in this chapter, we have focussed on mechanism by which these commensal confer resistance to various infections. Deciphering all this knowledge about gut-host interaction, the present chapter aims at understanding how to modulate gut microbiome for personalized medicine. It is well proven that microbiome acts as an important player in drug response variability or toxicity for various diseases. This provides a lead to understand ways by which microbiome could be used as a target for improving the efficacy of drugs along with safety by manipulating its composition. Various strategies have been adapted for this such as pathogen-specific approach, faecal microbiota transplantation (FMT), removing specific strain or species of a bacteria, inhibiting metabolic function of gut microbiota enzymes, introducing engineered strains in the gut and genetically modifying bacterial cells present in the gut. Thorough evaluation of all the available literature made us give our insight which suggests that developing microbial therapeutics which could be well adapted in the specific body environment is necessary for its efficient activity. Based on this observation, we suggest that construction of synthetic circuits which could be functionally active in in vivo conditions along with establishing regulatory frameworks for safety could be fruitful approach.
Gut-associated lymphoid tissues
LTiLymphoid tissue inducer
ILFsIsolated lymphoid follicles
AIDActivation-induced cytidine deaminase
EHECEnterohaemorrhagic E. coli
FXRFarnesoid X receptor
CDDLCytidine deaminase
CDIC. difficile infection
FMTFaecal microbiota transplantation
Gut microbiota comprises of diverse microbial population that is present in the intestine. This microbial population is of immense benefits to the host; most importantly, it shapes the gut immune system (Round and Mazmanian ). Many available sugar components present in the large intestine are not digested by host, these two enzymes help in breakdown of complex polysaccharides as an energy source, and this is the reason that bacteria of order Bacteroidales and Clostridiales are dominantly present in intestine. This type of co-evolution has been developed between the host and microbes through millions of years, wherein microbes help in various physiological processes of host and in turn they are benefited for their nutritional requirements. Along with these metabolic advantages, host microbiota helps in various other functions as discussed above to shape the immune system.
Font size:
Interval:
Bookmark:
Similar books «Metagenomic Systems Biology: Integrative Analysis of the Microbiome»
Look at similar books to Metagenomic Systems Biology: Integrative Analysis of the Microbiome. We have selected literature similar in name and meaning in the hope of providing readers with more options to find new, interesting, not yet read works.
Discussion, reviews of the book Metagenomic Systems Biology: Integrative Analysis of the Microbiome and just readers' own opinions. Leave your comments, write what you think about the work, its meaning or the main characters. Specify what exactly you liked and what you didn't like, and why you think so.