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Beth Bennett - Defy Aging: A Beginners Guide to the New Science of Longer Life and Better Health

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Defy Aging: A Beginners Guide to the New Science of Longer Life and Better Health: summary, description and annotation

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Learn why and how the body deteriorates as life goes on and offers an easy-read overview of new solutions coming out of current studies of aging.Wrinkles and gray hairs and misplaced keys--the obvious signs of getting older. Surprisingly, all of the miniscule events in our cells and organs that are responsible for aging begin their deterioration in our third decade. This book explains what is going on inside cells and organs that result in the outward appearances of aging. Readers will discover what causes skin to sag, hair to turn gray, blood vessels to stiffen, and other, mostly unwelcome events. Finally, and probably most importantly, the reader will be introduced to what can be done to stop or reverse this process. Beth Bennett provides an easy-to-read introduction to the science of aging: why and how the body deteriorates. She uses real world analogies to explain the chemical and cellular processes taking place in the body, along with newly-discovered solutions emerging from basic research labs.This book takes readers on a journey through many of their body processes, starting with the molecules in the cell, moving through the structures inside cells, into interactions between cells, tissues and organs making up our complex aging bodies. This progression will allow readers to appreciate how those age-related changes develop, and how interventions to mitigate those ill effects can act. Bennett explores the effects of aging in body systems that are important to all of us as we age: skin, muscle, bone, heart, and brain. In each of these body components, Bennett connects novel, science-based interventions with lifestyle modifications that extend health, as opposed to simply extending life.

Beth Bennett: author's other books


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Beth Bennett is a PhD geneticist with a background in evolutionary genetics and the science of aging. She has been published more than fifty times in peer-reviewed journals. She taught college biology for thirty years at the University of Colorado in Boulder, where she currently produces a radio show on science. She blogs on all things relating to aging.

Aagaard, P., C. Suetta, P. Caserotti, S. P. Magnusson, and M. Kjaer. Role of the Nervous System in Sarcopenia and Muscle Atrophy with Aging: Strength Training as a Countermeasure. Scandinavian Journal of Medicine and Science in Sports 20, no. 1 (2010): 4964. doi: 10.1111/j.1600-0838.2009.01084.x. PMID: 20487503.

Abdullah, K. M., Faizan A. Qais, Iqban Ahmad, and Imrana Naseem. Inhibitory Effect of Vitamin B3 against Glycation and Reactive Oxygen Species Production in HSA: An in vitro Approach. Archives of Biochemestry and Biophysics 627 (2017): 2129. doi: 10.1016/j.abb.2017.06.009. PMID: 28624351.

Afizah, Hassan, and James H. Hui. Mesenchymal Stem Cell Therapy for Osteoarthritis. Journal of Clinical Orthopaedics and Trauma 7, no. 3 (2016): 17782. doi: 10.1016/j.jcot.2016.06.006. PMID: 27489413.

Akers, Emma J., Stephen J. Nicholls, and Belinda A. Di Bartolo. Plaque Calcification: Do Lipoproteins Have a Role? Arteriosclerosis, Thrombosis and Vascular Biology 39, no. 10 (2019): 190210. doi: 10.1161/ATVBAHA.119.311574. PMID: 31462089.

Alagiakrishnan, Kanniiram, Angela Juby, David Hanley, Wayne Tymchak, and Anne Sclater A. Role of Vascular Factors in Osteoporosis. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 58, no. 4 (2003): 36226. doi: 10.1093/gerona/58.4.m362. PMID: 12663699.

de Almeida Jackix, Elisia, Florencia Cneo, Jamie Amaya-Farfan, Juvenal V. de Assuno, and Kesia D. Quintaes. A Food Supplement of Hydrolyzed Collagen Improves Compositional and Biodynamic Characteristics of Vertebrae in Ovariectomized Rats. Journal of Medicinal Food 13, no. 6 (2010): 138590. doi: 10.1089/jmf.2009.0256. PMID: 20874246.

Al-Sheraji, Sadeq Hasan, Amin Ismail, Mohd Yazid Manap, Shuhaimi Mustafa, Rokiah Mohd Yusof, and Fouad Abdulrahman Hassan. Hypocholesterolaemic Effect of Yoghurt Containing Bifidobacterium pseudocatenulatum G4 or Bifidobacterium longum BB536. Food Chemistry 135, no. 2 (2012): 35661. doi: org/10.1016/j.foodchem.2012.04.120.

Aoyagi, Atsushi, Carlo Condello, Jan Sthr, Weizhou Yue, Brianna M. Rivera, Joanna C. Lee, Amanda L. Woerman, et al. A and Tau Prion-like Activities Decline with Longevity in the Alzheimers Disease Human Brain. Science and Translational Medicine 11, no. 490 (2019): eaat8462. doi: 10.1126/scitranslmed.aat8462. PMID: 31043574.

Armstrong, Sue. Borrowed Time: The Science of How and Why We Age. London: Bloomsbury Sigma, 2019.

Arnold, Ann-Sophie, Anna Egger, and Christof Handschin. PGC-1 and Myokines in the Aging MuscleA Mini-Review. Gerontology 57, no. 1 (2011): 3743. doi: 10.1159/000281883. PMID: 20134150.

Atherton, P. J., J. Babraj, K. Smith, J. Singh, M. J. Rennie, and H. Wackerhage. Selective Activation of AMPK-PGC-1alpha or PKB-TSC2-mTOR Signaling Can Explain Specific Adaptive Responses to Endurance or Resistance Training-like Electrical Muscle Stimulation. FASEB Journal 19, no. 7 (2005): 78688. doi: 10.1096/fj.04-2179fje. PMID: 15716393.

Attia, Peter. Controversial Topic Affecting All WomenThe Role of Hormone Replacement Therapy through Menopause and BeyondThe Compelling Case for Long-Term HRT and Dispelling the Myth That It Causes Breast Cancer. Podcasts. February 25, 2019. https://peterattiamd.com/caroltavris-avrumbluming/.

. Studying Studies: Part IIObservational Epidemiology. Topics. January 15, 2018. https://peterattiamd.com/ns002.

Aubert, Geraldine, Mark Hills, and Peter M. Lansdorp. Telomere Length MeasurementCaveats and a Critical Assessment of the Available Technologies and Tools. Mutation Research 730, nos. 12 (2012): 5967. doi: 10.1016/j.mrfmmm.2011.04.003. PMID: 21663926.

Azuma, Kotaro, and Satoshi Inoue. Vitamin K Benefits in Aging and Cancer. In Aging Mechanisms, edited by Nozomo Mori and Inhee Mook-Jung, 22339. Tokyo, Japan: Springer, 2015.

Balasubramanian, Priya, Chia-Weh Cheng, Federica Madia, Luigi Fontana, Mario Mirisola, Jaime Guevara-Aguirre, et al. Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger But Not Older Population. Cell Metabolism 19, no. 3 (2014): 40717.

Barter, Philip J., H. Brian Brewer Jr., M. John Chapman, Charles H. Hennekens, Daniel J. Rader, and Alan R. Tall. Cholesteryl Ester Transfer Protein: A Novel Target for Raising HDL and Inhibiting Atherosclerosis. Arteriosclerosis, Thrombosis and Vascular Biology 23, no. 2 (2003): 16067. doi: 10.1161/01.atv.0000054658.91146.64. PMID: 12588754.

Bartke, Andrzej, and Nana Quainoo. Impact of Growth Hormone-Related Mutations on Mammalian Aging. Frontiers in Genetics 9 (2018): 586. doi: 10.3389/fgene.2018.00586.

Bartke, Andrzej, and Westbrook Reyhan. Metabolic Characteristics of Long-Lived Mice. Frontiers in Genetics 3 (2012): 288. doi: 10.3389/fgene.2012.00288.

Barzilai, Nur, Jill P. Crandall, Stephen B. Kritchevsky, and Mark A. Espeland. Metformin as a Tool to Target Aging. Cell Metabolism 23, no. 6 (2016): 106065. https://doi.org/10.1016/j.cmet.2016.05.011.

Basisty, Nathan., Dao-Fu Dai, Ami Gagnidze, Lemuel Gitari, Jeanne Fredrickson, Yvonne Maina, Richard P. Beyer, Mary J. Emond, Edward J. Hsieh, Michael J. MacCoss, George M. Martin, and Peter S. Rabinovitch. Mitochondrial-Targeted Catalase Is Good for the Old Mouse Proteome, But Not for the Young: Reverse Antagonistic Pleiotropy? Aging Cell 15, no. 4 (2016): 63445. https://doi.org/10.1111/acel.12472.

Bell, Steven, Marina Daskalopoulou, Eleni Rapsomaniki, Julie George, Annie Britton, Martin Bobak, Juan P. Casas, Caroline E. Dale, Spiros Denaxas, Anoop Shah, and Harry Hemingway. Association between Clinically Recorded Alcohol Consumption and Initial Presentation of 12 Cardiovascular Diseases: Population Based Cohort Study Using Linked Health Records. British Medical Journal 356 (2017): j909. doi: 10.1136/bmj.j909. PMID: 28331015.

Bennett, Beth. Stem Cells to Treat Osteoarthritis. Trail Runner, 2018. https://trailrunnermag.com/training/stem-the-joint-aging-tide.html.

. What Exactly Is Osteoporosis? Blog post, February 28, 2019. http://senesc-sense.com/what-exactly-is-osteoporosis/.

Berebichez-Fridman, Roberto, Ricardo Gmez-Garca, Julio Granados-Montiel, Enrique Berebichez-Fastlicht, Anell Olivos-Meza, Julio Granados, Cristain Velasquillo, and Clemente Ibarra. The Holy Grail of Orthopedic Surgery: Mesenchymal Stem CellsTheir Current Uses and Potential Applications. Stem Cells International (2017): 2638305. doi: 10.1155/2017/2638305. PMID: 28698718.

Besse-Patin, A., E. Montastier, C. Vinel, I. Castan-Laurell, K. Louche, C. Dray, D. Daviaud, L. Mir, M. A. Marques, C. Thalamas, et al. Effect of Endurance Training on Skeletal Muscle Myokine Expression in Obese Men: Identification of Apelin as a Novel Myokine. International Journal of Obesity (London) 38, no. 5 (2014): 70713. doi: 10.1038/ijo.2013.158. PMID: 23979219.

Bhandari, Mohit, Raveendhara R. Bannur, Eric M. Babins, Johanna Martel-Pelletier, Moin Khan, Jean-Pierre Raynauld, Reynata Frankovich, Deanna Mcleod, Tahira Devji, Mark Phillips, et al. Intra-articular Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Canadian Evidence-Based Perspective. Therapeutic Advances in Musculoskeletal Disease 9, no. 9 (2017): 23146. https://doi.org/10.1177/1759720X17729641.

Bickel, C. Scott, James M. Cross, and Marcas M. Bamman. Exercise Dosing to Retain Resistance Training Adaptations in Young and Older Adults.

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