Contents
Guide
Pages
SEVENTH
EDITION
Fields
VIROLOGY
VOLUME 1: Emerging Viruses
SEVENTH
EDITION
Fields
VIROLOGY
VOLUME 1: Emerging Viruses
EDITORS-IN-CHIEF
Peter M. Howley , MD
Shattuck Professor of Pathological Anatomy
Department of Immunology
Harvard Medical School
Boston, Massachusetts
David M. Knipe , PhD
Higgins Professor of Microbiology and Molecular Genetics
Department of Microbiology
Chair, Harvard Program in Virology
Harvard Medical School
Boston, Massachusetts
VOLUME ASSOCIATE EDITOR
Sean P. J. Whelan , PhD
Marvin A. Brennecke Distinguished Professor
Chair, Molecular Microbiology
Washington University in Saint Louis, School of Medicine
Saint Louis, Missouri
ASSOCIATE EDITORS
Jeffrey I. Cohen , MD
Chief, Laboratory of Infectious Diseases
National Institute of Allergy and Infectious Diseases
National Institutes of Health
Bethesda, Maryland
Lynn Enquist , PhD
Henry L. Hillman Professor of Molecular Biology
Department of Molecular Biology
Princeton University
Princeton, New Jersey
Blossom Damania , PhD
Boshamer Distinguished Professor and Vice Dean for Research, School of Medicine
Department of Microbiology and Immunology
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina
Eric O. Freed , PhD
Director
HIV Dynamics and Replication Program Center for Cancer Research
National Cancer Institute
Frederick, Maryland
![Acquisitions Editor Nicole Dernoski Development Editor Ariel Winter Senior - photo 2](/uploads/posts/book/358843/images/WK_CMYK_TTLPG.jpg)
Acquisitions Editor: Nicole Dernoski
Development Editor: Ariel Winter
Senior Editorial Coordinator: David Murphy
Marketing Manager: Phyllis Hitner
Production Project Manager: Sadie Buckallew
Design Coordinator: Stephen Druding
Senior Manufacturing Coordinator: Beth Welsh
Prepress Vendor: SPi Global
Seventh Edition
Copyright 2021 Wolters Kluwer
Copyright 2013, 2007, 2001 Lippincott Williams & Wilkins, a Wolters Kluwer business. Copyright 1995 Lippincott-Raven Publishers. Copyright 1990, 1986 Raven Press. All rights reserved. This book is protected by copyright. No part of this book may be reproduced or transmitted in any form or by any means, including as photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. To request permission, please contact Wolters Kluwer at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at (products and services).
9 8 7 6 5 4 3 2 1
Printed in China
Cataloging-in-Publication Data available on request from the Publisher
ISBN: 978-1-9751-1254-7
This work is provided as is, and the publisher disclaims any and all warranties, express or implied, including any warranties as to accuracy, comprehensiveness, or currency of the content of this work.
This work is no substitute for individual patient assessment based upon healthcare professionals examination of each patient and consideration of, among other things, age, weight, gender, current or prior medical conditions, medication history, laboratory data and other factors unique to the patient. The publisher does not provide medical advice or guidance and this work is merely a reference tool. Healthcare professionals, and not the publisher, are solely responsible for the use of this work including all medical judgments and for any resulting diagnosis and treatments.
Given continuous, rapid advances in medical science and health information, independent professional verification of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options should be made and healthcare professionals should consult a variety of sources. When prescribing medication, healthcare professionals are advised to consult the product information sheet (the manufacturers package insert) accompanying each drug to verify, among other things, conditions of use, warnings and side effects and identify any changes in dosage schedule or contraindications, particularly if the medication to be administered is new, infrequently used or has a narrow therapeutic range. To the maximum extent permitted under applicable law, no responsibility is assumed by the publisher for any injury and/or damage to persons or property, as a matter of products liability, negligence law or otherwise, or from any reference to or use by any person of this work.
shop.lww.com
Contributors
Gaya K. Amarasinghe , PhD
Professor
Department of Pathology and Immunology
Washington University School of Medicine
St. Louis, Missouri
John N. Barr , PhD
Associate Professor
Faculty of Biological Sciences
University of Leeds
Leeds, United Kingdom
Ralf Bartenschlager , PhD
Division Head and Group Leader
Department of Infectious Diseases, Molecular Virology
Heidelberg University
Heidelberg, Baden-Wrttemberg, Germany
Dennis A. Bente , DVM, PhD
Associate Professor
Department of Microbiology & Immunology
University of Texas Medical Branch/Galveston National Laboratory
Galveston, Texas
Christopher C. Broder , PhD
Professor and Chair
Department of Microbiology and Immunology
Uniformed Services University of the Health Sciences
Bethesda, Maryland
Michael J. Buchmeier , PhD
Professor
Department of Medicine
University of California, Irvine
Irvine, California
Carolyn B. Coyne , PhD
Professor of Pediatrics
Department of Pediatrics
Childrens Hospital of Pittsburgh of UPMC
Pittsburgh, Pennsylvania
Juan Carlos de la Torre , PhD
Professor
Department of Immunology and Microbiology
The Scripps Research Institute
La Jolla, California
Michael S. Diamond , MD, PhD
The Herbert S. Gasser Professor
Departments of Medicine, Molecular Microbiology, Pathology & Immunology
Associate Director
The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs
Washington University School of Medicine
St. Louis, Missouri
Jemma L. Geoghegan , PhD
Lecturer
Department of Biological Sciences
Macquarie University
Sydney, New South Wales, Australia
Kim Y. Green , PhD
Senior Investigator
Department of NIAID
National Institutes of Health
Rockville, Maryland
Diane E. Griffin , MD, PhD
Professor
Department of Molecular Microbiology and Immunology
Bloomberg School of Public Health
Johns Hopkins University
Baltimore, Maryland
Edward C. Holmes , PhD
ARC Australian Laureate Fellow and Professor
School of Life and Environmental Sciences and Sydney Medical School
University of Sydney
Sydney, New South Wales, Australia
Yoshihiro Kawaoka , DVM, PhD
Professor
Influenza Research Institute
Department of Pathobiological Sciences
School of Veterinary Medicine
University of WisconsinMadison
Madison, Wisconsin
Florian Krammer , PhD