Mark A. Simmons - Pharmacology - An Illustrated Review

Pharmacology
An Illustrated Review

Mark A. Simmons, PhD

Professor of Pharmacology
Department of Integrative Medical Sciences
College of Medicine, and
Department of Pharmaceutical Sciences
College of Pharmacy
Northeast Ohio Medical University
Rootstown, Ohio

Pharmacology Graduate Program
School of Biomedical Sciences
Kent State University
Kent, Ohio

Thieme

New York Stuttgart

Thieme Medical Publishers, Inc.
333 Seventh Ave.
New York, NY 10001

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Illustrations: By Jrgen Wirth (Professor of Visual Communication, University of Applied Sciences, Darmstadt, Germany) from Heinz Lllmann, Klaus Mohr, Lutz Hein, and Detlef Bieger; Color Atlas of Pharmacology, third edition, Thieme 2005, and other books in the Thieme Flexibook, except as noted.

Library of Congress Cataloging-in-Publication Data

Simmons, Mark A.

Pharmacology: an illustrated review / Mark A. Simmons.

p. ; cm. (Illustrated review series)

Includes index.

Summary: Pharmacology: An Illustrated Review covers the facts and concepts you must master for classroom and USMLE successas well as key knowledge for daily clinical practice. Thieme's new illustrated Review Series serves an important dual purpose for medical studentsboth concise course review and high-yield USMLE test preparation. Covering all the basic science subjects that you will take in medical school and that will be found on the USMLE Step 1, the series features unparalleled color illustrations, a streamlined format, and hundreds of print and online study questions and answersall designed to increase your mastery of the topic, promote classroom success, and boost your confidence for the exam! Combining targeted reviews of the basic sciences with a multitude of exam questions for easy reinforcement and retention, these efficient-to-study books put success at your fingertipsProvided by publisher.

ISBN 978-1-60406-205-2 (pbk. : alk. paper) 1. PharmacologyExaminations, questions, etc. 2. PharmacologyAtlases. 3. PharmacologyOutlines, syllabi, etc. I. Title. II. Series: Thieme illustrated review series.

[DNLM: 1. Pharmacological PhenomenaAtlases. 2. Pharmacological PhenomenaExamination Questions. 3. Pharmacological PhenomenaOutlines. QV 18.2]

RM301.13.S56 2012

615.1076dc23

2011028084

Copyright 2012 by Thieme Medical Publishers, Inc. This book, including all parts thereof, is legally protected by copyright. Any use, exploitation, or commercialization outside the narrow limits set by copyright legislation without the publisher's consent is illegal and liable to prosecution. This applies in particular to photostat reproduction, copying, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Important note: Medical knowledge is ever-changing. As new research and clinical experience broaden our knowledge, changes in treatment and drug therapy may be required. The authors and editors of the material herein have consulted sources believed to be reliable in their efforts to provide information that is complete and in accord with the standards accepted at the time of publication. However, in view of the possibility of human error by the authors, editors, or publisher of the work herein or changes in medical knowledge, neither the authors, editors, nor publisher, nor any other party who has been involved in the preparation of this work, warrants that the information contained herein is in every respect accurate or complete, and they are not responsible for any errors or omissions or for the results obtained from use of such information. Readers are encouraged to confirm the information contained herein with other sources. For example, readers are advised to check the product information sheet included in the package of each drug they plan to administer to be certain that the information contained in this publication is accurate and that changes have not been made in the recommended dose or in the contraindications for administration. This recommendation is of particular importance in connection with new or infrequently used drugs.

Some of the product names, patents, and registered designs referred to in this book are in fact registered trademarks or proprietary names even though specific reference to this fact is not always made in the text. Therefore, the appearance of a name without designation as proprietary is not to be construed as a representation by the publisher that it is in the public domain.

Printed in Canada

5 4 3 2 1

ISBN 978-1-60406-205-2

Your Illustrated Review Series book is a two-part package that will be invaluable for your course and exams. In addition to the wealth of illustrations and information in this book, you also get access to 400 review questions online at WinkingSkull.com. These questions (200 from the book plus 200 more) both factual and clinical-case-based multiple choice all have answer explanations for right and wrong answers. Test yourself and get immediate feedback, quickly identifying areas of mastery or for further study.

After completing a short form to verify your e-book purchase, you will be provided with the instructions and access codes necessary to retrieve access to the review questions.

Please visit http://www.thieme.com/bonuscontent to get started today!

To the teachers who cultivated my interest in pharmacology,
To the colleagues who have collaborated with me in teaching and research,
To the students who have made the teaching of pharmacology so rewarding, and
To Robin, my eternal inspiration.

Contents

Preface

Pharmacology, the study of the effects of drugs on the body, is one of the most important disciplines that must be mastered to be successful in the practice of medicine or the biomedical sciences. The prevention or treatment of almost every disease involves the use of drugs. Furthermore, many patients seek medical help as a result of drug side effects or toxicities.

PharmacologyAn Illustrated Review covers the facts of pharmacology and integrates the concepts that you must master for success in the classroom and for the USMLE. It provides a concise study aid for pharmacology courses. It can also be used as a succinct source of key knowledge for daily clinical practice.

This book is in a streamlined bullet-point format and includes hundreds of full-color illustrations that demonstrate pharmacological processes and modes of action. For each pharmaceutical agent or group of agents, mechanisms of action, pharmacokinetics, uses, contraindications, and side effects are discussed.

Sidebars connect pharmacological concepts in the text with normal function (orange), fundamental biochemical, genetic, and embryologic processes (green), and disease and treatment (blue).

For self-testing, the text includes both factual and USMLE-style questions. All of the questions are accompanied by explanatory answers. The 200 questions and answers in the text are supplemented by an additional 200 questions and answers online at WinkingSkull. com via the scratch-off code in the book. The questions provide intensive practice, offer immediate feedback, and allow you to quickly identify areas for further study. I tell the students in my pharmacology courses that if they can answer the questions in this book and online correctly, they will have no problem with the pharmacology portions of the licensing exams.