Abbas Abul K. - Robbins and Cotran Pathologic Basis of Disease, Professional Edition

1. Tables in Chapter 1
2. Tables in Chapter 2
3. Tables in Chapter 3
4. Tables in Chapter 4
5. Tables in Chapter 5
6. Tables in Chapter 6
7. Tables in Chapter 7
8. Tables in Chapter 8
9. Tables in Chapter 9
10. Tables in Chapter 10
11. Tables in Chapter 11
12. Tables in Chapter 12
13. Tables in Chapter 13
14. Tables in Chapter 14
15. Tables in Chapter 15
16. Tables in Chapter 16
17. Tables in Chapter 17
18. Tables in Chapter 18
19. Tables in Chapter 19
20. Tables in Chapter 20
21. Tables in Chapter 21
22. Tables in Chapter 22
23. Tables in Chapter 23
24. Tables in Chapter 24
25. Tables in Chapter 25
26. Tables in Chapter 26
27. Tables in Chapter 27
28. Tables in Chapter 28

1. Figures in Chapter 1
2. Figures in Chapter 2
3. Figures in Chapter 3
4. Figures in Chapter 4
5. Figures in Chapter 5
6. Figures in Chapter 6
7. Figures in Chapter 7
8. Figures in Chapter 8
9. Figures in Chapter 9
10. Figures in Chapter 10
11. Figures in Chapter 11
12. Figures in Chapter 12
13. Figures in Chapter 13
14. Figures in Chapter 14
15. Figures in Chapter 15
16. Figures in Chapter 16
17. Figures in Chapter 17
18. Figures in Chapter 18
19. Figures in Chapter 19
20. Figures in Chapter 20
21. Figures in Chapter 21
22. Figures in Chapter 22
23. Figures in Chapter 23
24. Figures in Chapter 24
25. Figures in Chapter 25
26. Figures in Chapter 26
27. Figures in Chapter 27
28. Figures in Chapter 28
29. Figures in Chapter 29

First and foremost we wish to express our respects and deep gratitude to the late Dr. Nelson Fausto for having been the coeditor of the last two editions of this book. Many of his words are retained in this edition and will continue to benefit future readers. He shall be greatly missed.

All three of us offer thanks to our contributing authors for their commitment to this textbook. Many are veterans of previous editions; others are new to the ninth edition. All are acknowledged in the table of contents. Their names lend authority to this book, for which we are grateful. As in previous editions, the three of us have chosen not to add our own names to the chapters we have been responsible for writing, in part or whole.

Many colleagues have enhanced the text by reading various chapters and providing helpful critiques in their area of expertise. They include Drs. Seungmin Hwang, Kay McLeod, Megan McNerney, Ivan Moskovitz, Jeremy Segal, Humaira Syed, Helen Te, and Shu-Yuan Xiao at the University of Chicago; Marcus Peter at Northwestern University, Chicago; Dr Meenakshi Jolly at Rush University, Chicago; Drs. Kimberley Evason, Kuang-Yu Jen, Richard Jordan, Marta Margeta, and Zoltan Laszik at the University of California, San Francisco; Dr. Antony Rosen at Johns Hopkins University; Dr. Lundy Braun at Brown University; Dr. Peter Byers at the University of Washington; Drs. Frank Bunn, Glenn Dranoff, and John Luckey at Harvard Medical School; Dr. Richard H. Aster at the Milwaukee Blood Center and Medical College of Wisconsin; and Dr. Richard C. Aster at Colorado State University. Special thanks are due to Dr. Raminder Kumar for updating clinical information and extensive proofreading of many chapters in addition to her role as consulting clinical editor for several chapters. Many colleagues provided photographic gems from their collections. They are individually acknowledged in the text.

Our administrative staff needs special mention since they maintain order in the chaotic lives of the authors and have willingly chipped in when needed for multiple tasks relating to the text. At the University of Chicago, they include Ms. Nhu Trinh and Ms. Garcia Wilson; at the University of California at San Francisco, Ms. Ana Narvaez; and at the Brigham and Women's Hospital, Muriel Goutas. All of the graphic art in this book was created by Mr. James Perkins, Professor of Medical Illustration at Rochester Institute of Technology. His ability to convert complex ideas into simple and aesthetically pleasing sketches has considerably enhanced this book.

Many individuals associated with our publisher, Elsevier (under the imprint of WB Saunders), need our special thanks. Outstanding among them is Jennifer Nemec, Project Manager, and our partner in the production of this book. Her understanding of the needs of the authors, promptness in responding to requests (both reasonable and unreasonable), and cheerful demeanor went a long way in reducing our stress and making our lives less complicated. Mr. William (Bill) Schmitt, Publishing Director of Medical Textbooks, has always been our cheerleader and is now a dear friend. Our thanks also go to Managing Editor Rebecca Gruliow and Design Manager Lou Forgione at Elsevier. Undoubtedly there are many others who may have been left out unwittinglyto them we say thank you and tender apologies for not acknowledging you individually.

Efforts of this magnitude take a toll on the families of the authors. We thank our spouses, Raminder Kumar, Ann Abbas, and Erin Malone for their patience, love, and support of this venture, and for their tolerance of our absences.

Vinay Kumar

Abul K. Abbas

Jon C. Aster

Richard N. Mitchell

Chapter Contents

See TARGETED THERAPY available online at www.studentconsult.com

Pathology literally translates to the study of suffering (Greek pathos = suffering, logos = study); more prosaically, the term pathology is invoked to represent the study of disease. Germane to this opening chapter, Virchow coined the term cellular pathology to emphasize the basic tenet that all diseases originate at the cellular level. Thus, modern pathology is basically the study of cellular abnormalities. Therefore, diseases and the underlying mechanisms are best understood in the context of normal cellular structure and function.

It is unrealistic (and even undesirable) to condense the vast and fascinating field of cell biology into a single chapter. Moreover, students of biology are likely quite familiar with many of the broader concepts of cell structure and function. Consequently, rather than attempting a comprehensive review, our goal is to survey some basic principles and highlight some recent advances that are relevant to the pathologic basis of disease that is emphasized throughout the text. We hope this chapter will be useful to review key topics in normal cell biology as they apply to the areas of Pathology that are covered from onwards.