Gonzalo de Gonzalo - Biocatalysis: An Industrial Perspective

Rebecca Buller, Katrin Hecht, Marco Antonio Mirata and Hans-Peter Meyer

Madhuresh Kumar Sethi, Purbita Chakraborty and Rohit Shukla

Roland Wohlgemuth

Javier Gonzlez Sabn and Francisco Mors

Ramesh N. Patel

Elina Siirola, Ahir Pushpanath, Desmond M. Schofield and Paolo Braiuca

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Biocatalysis

An Industrial Perspective

Catalysis Series

Editor-in-chief:

Chris Hardacre, University of Manchester, UK

Series editors:

Bert Klein Gebbink, Utrecht University, The Netherlands

Jose Rodriguez, Brookhaven National Laboratory, USA

Titles in the series:

1: Carbons and Carbon Supported Catalysts in Hydroprocessing

2: Chiral Sulfur Ligands: Asymmetric Catalysis

3: Recent Developments in Asymmetric Organocatalysis

4: Catalysis in the Refining of FischerTropsch Syncrude

5: Organocatalytic Enantioselective Conjugate Addition Reactions: A Powerful Tool for the Stereocontrolled Synthesis of Complex Molecules

6: N-Heterocyclic Carbenes: From Laboratory Curiosities to Efficient Synthetic Tools

7: P-Stereogenic Ligands in Enantioselective Catalysis

8: Chemistry of the MoritaBaylisHillman Reaction

9: Proton-Coupled Electron Transfer: A Carrefour of Chemical Reactivity Traditions

10: Asymmetric Domino Reactions

11: CH and CX Bond Functionalization: Transition Metal Mediation

12: Metal Organic Frameworks as Heterogeneous Catalysts

13: Environmental Catalysis Over Gold-Based Materials

14: Computational Catalysis

15: Catalysis in Ionic Liquids: From Catalyst Synthesis to Application

16: Economic Synthesis of Heterocycles: Zinc, Iron, Copper, Cobalt, Manganese and Nickel Catalysts

17: Metal Nanoparticles for Catalysis: Advances and Applications

18: Heterogeneous Gold Catalysts and Catalysis

19: Conjugated Linoleic Acids and Conjugated Vegetable Oils

20: Enantioselective Multicatalysed Tandem Reactions

21: New Trends in Cross-Coupling: Theory and Applications

22: Atomically-Precise Methods for Synthesis of Solid Catalysts

23: Nanostructured Carbon Materials for Catalysis

24: Heterocycles from Double-Functionalized Arenes: Transition Metal Catalyzed Coupling Reactions

25: Asymmetric Functionalization of CH Bonds

26: Enantioselective Nickel-catalysed Transformations

27: N-Heterocyclic Carbenes: From Laboratory Curiosities to Efficient Synthetic Tools, 2nd edition

28: Zeolites in Catalysis: Properties and Applications

29: Biocatalysis: An Industrial Perspective

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Biocatalysis

An Industrial Perspective

Edited by

Gonzalo de Gonzalo

University of Seville, Spain

Email:

and

Pablo Domnguez de Mara

Sustainable Momentum, SL, Las Palmas de Gran Canaria, Spain

Email:

Catalysis Series No. 29

Print ISBN: 978-1-78262-619-0

PDF ISBN: 978-1-78262-999-3

EPUB ISBN: 978-1-78801-246-1

ISSN: 1757-6725

A catalogue record for this book is available from the British Library

The Royal Society of Chemistry 2018

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Preface

Biocatalysis has acquired a relevant role in organic synthesis over recent decades, stimulated by the outstanding developments in microbiology, molecular biology, and bioinformatics, together with a mature know-how in medium engineering and enzyme immobilization. Remarkable breakthroughs in those areas have enabled a wide accessibility to genetically-designed (tailored) biocatalysts as required at industrial scale, and in many cases at acceptable prices. The accumulated knowledge has triggered the implementation of enzyme catalysis in commercial processes to manufacture a broad product portfolio , leading to highly selective reactor set-ups, often conducted under mild conditions, and in many cases in an environmentally-friendly manner.

The penetration of biocatalysis in industry is not, however, a straightforward task. Interdisciplinary teams need to act in a coordinated way, and often under time-pressured deadlines. Remarkably, whilst there is ample information available on how a biocatalytic process can (academically) be set up, available knowledge emphasizing the link between laboratory research and industrial processes is somewhat scarce. To enable a better transition between these two worlds, the participation of industrialists in the academic arena appears crucial to inspire an industrial conceptual approach to the biocatalytic studies.