Gladman Dafna D. - Psoriatic Arthritis

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Psoriatic arthritis

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Dafna D. Gladman MD , FRCPC

Professor of Medicine, University of Toronto;
Senior Scientist, Toronto Western Research Institute;
University Health Network, Toronto Western Hospital,
Toronto, Ontario, Canada

Vinod Chandran MBBS , MD , DM

Clinical Research Fellow, University of Toronto;
Centre for Prognosis Studies in the Rheumatic Diseases;
University Health Network, Toronto Western Hospital,
Toronto, Ontario, Canada

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Key points

Psoriasis is a chronic inflammatory skin condition

Psoriatic arthritis is an inflammatory arthritis occurring in patients with psoriasis

Psoriatic arthritis affects 1030% of patients with psoriasis

Psoriatic arthritis affects the peripheral and spinal joints

CASPAR criteria facilitate the diagnosis

Psoriasis is a chronic inflammatory skin condition which presents most commonly with red plaques over the extensor surfaces of the elbows and knees, as well as in the scalp ().

The occurrence of a form of arthritis among patients with psoriasis was first noted in the nineteenth century, although evidence of the disease was noted in archeological findings from the Judean desert, dating the disease much earlier than that. Baron Aliberti first described the association between psoriasis and arthritis (). Later in the nineteenth century several French physicians recognized the presence of a form of arthritis among patients with psoriasis. However, over the ensuing years many investigators considered the arthritis associated with psoriasis to be a variant of rheumatoid arthritis, which was the main known inflammatory form of arthritis at the time. Psoriatic arthritis was finally recognized as an entity separate from rheumatoid arthritis when it was found that the majority of patients with psoriatic arthritis were negative for a test for