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Natalie E. Cusano (editor) - Osteoporosis: A Clinical Casebook

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Natalie E. Cusano (editor) Osteoporosis: A Clinical Casebook

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Comprised of clinical cases of patients with osteoporosis, this concise, practical casebook will provide clinicians with the best real-world strategies to properly diagnose and treat the various elements of the disorder they may encounter. It presents a detailed cross-section of patients across all age groups, with different etiologies of the disease and possible complications, to present sensible management scenarios to physicians treating patients with osteoporosis. The cases presented include considerations for screening and diagnosis, assessment tools, nutrition and lifestyle choices, medical treatments, specific populations including men, the elderly and athletes, and more.
Pragmatic and reader-friendly, Osteoporosis: A Clinical Casebook is an excellent resource for primary care providers, endocrinologists, rheumatologists, and other clinicians caring for patients with this disease.

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Book cover of Osteoporosis Editor Natalie E Cusano Osteoporosis A - photo 1
Book cover of Osteoporosis
Editor
Natalie E. Cusano
Osteoporosis
A Clinical Casebook
1st ed. 2021
Logo of the publisher Editor Natalie E Cusano Division of Endocrinology - photo 2
Logo of the publisher
Editor
Natalie E. Cusano
Division of Endocrinology, Lenox Hill Hospital, New York, NY, USA
ISBN 978-3-030-83950-5 e-ISBN 978-3-030-83951-2
https://doi.org/10.1007/978-3-030-83951-2
The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021
This work is subject to copyright. All rights are solely and exclusively licensed by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.
The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This Springer imprint is published by the registered company Springer Nature Switzerland AG

The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

Preface

Osteoporotic fractures are expected to increase with the aging of the population, causing a significant stress on healthcare systems worldwide. Despite noninvasive methods for screening and highly effective therapies, osteoporosis remains underdiagnosed and undertreated. The first report on the disease from the United States Office of the Surgeon General stated that bone health was critically important for overall health and well-being. The consequences of osteoporotic fractures are excess mortality, morbidity including total or partial disability, loss of independence, and impaired quality of life, in addition to economic costs.

This book is designed to aid in the management of osteoporosis through a patient-focused approach. The authors have related clinical pearls from their extensive backgrounds to address some of the challenges providers face in the treatment of osteoporosis. I would like to acknowledge the contributors for sharing their experience, and hope that this book assists the reader in reducing the burden of the disease for their patients, male and female, and across the age spectrum.

Natalie E. Cusano
New York, NY, USA
Abbreviations
25OHD

25-hydroxyvitamin D

95% CI

95% confidence interval

BMI

Body mass index

BMD

Bone mineral density

CT

Computed tomography

DXA

Dual energy X-ray absorptiometry

eGFR

Estimated glomerular filtration rate

EMA

European Medicines Agency

FSH

Follicle stimulating hormone

FDA

Food and Drug Administration

FRAX

Fracture risk assessment tool

HR

Hazard ratio

IV

Intravenous

IU

International units

LH

Luteinizing hormone

OR

odds ratio

PTH

Parathyroid hormone

PO

per os/by mouth

RANK

Receptor activator of B

RANKL

Receptor activator of B ligand

RR

Relative risk

SC

Subcutaneous

TSH

Thyroid stimulating hormone

Contents
Natalie E. Cusano
Joanne Bruno and Melissa Sum
Barbara C. Silva and Maria Marta Sarquis Soares
Guido Zavatta and Bart L. Clarke
Laura E. Ryan and Steven W. Ing
Bente L. Langdahl
Brinda Manchireddy , Maria Gabriela Negron Marte and Robert A. Adler
Parinya Samakkarnthai and Jad G. Sfeir
Katherine Haseltine and Jessica Starr
Valerie S. Barta , Maria V. DeVita and Jordan L. Rosenstock
Swetha Murthi and Emilia Pauline Liao
Sumeet Jain and Pauline Camacho
Natalie E. Cusano
Cristiana Cipriani and John P. Bilezikian
Priyanka Majety and Alan Ona Malabanan
E. Michael Lewiecki
Contributors
Robert A. Adler
Endocrinology and Metabolism Section, Central Virginia Veterans Affairs Health Care System and Division of Endocrinology, Metabolism, and Diabetes, Virginia Commonwealth University, Richmond, VA, USA
Valerie S. Barta
Division of Nephrology, Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, NY, USA
John P. Bilezikian
Division of Endocrinology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA
Joanne Bruno
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, New York University Langone Medical Center, New York, NY, USA
Pauline Camacho
Division of Endocrinology, Loyola University Osteoporosis and Metabolic Bone Disease Center, Loyola University Medical Center, Maywood, IL, USA
Cristiana Cipriani
Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy
Bart L. Clarke
Mayo Clinic E18-A, Rochester, MN, USA
Natalie E. Cusano
Division of Endocrinology, Lenox Hill Hospital, New York, NY, USA
Maria V. DeVita
Division of Nephrology, Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, NY, USA
Katherine Haseltine
Hospital for Special Surgery, New York, NY, USA
Steven W. Ing
Division of Endocrinology, Diabetes and Metabolism, The Ohio State University Wexner Medical Center, Columbus, OH, USA
Sumeet Jain
Division of Endocrinology, Rush University Medical Center, Chicago, IL, USA
Bente L. Langdahl
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
E. Michael Lewiecki
New Mexico Clinical Research & Osteoporosis Center, Albuquerque, NM, USA
Emilia Pauline Liao
Northwell Health Lenox Hill Hospital, New York, NY, USA
Priyanka Majety
Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA
Alan Ona Malabanan
Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA
Harvard Medical School, Boston, MA, USA
Brinda Manchireddy
Endocrinology and Metabolism Section, Central Virginia Veterans Affairs Health Care System and Division of Endocrinology, Metabolism, and Diabetes, Virginia Commonwealth University, Richmond, VA, USA
Maria Gabriela Negron Marte
Endocrinology and Metabolism Section, Central Virginia Veterans Affairs Health Care System and Division of Endocrinology, Metabolism, and Diabetes, Virginia Commonwealth University, Richmond, VA, USA
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