F. John Gennari - Acid-Base Disorders and Their Treatment

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Acid-Base Disorders and Their Treatment

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Edited by

F.John Gennari
University of Vermont College of Medicine
Burlington, Vermont U.S.A.

Horacio J.Adrogu
Baylor College of Medicine
Houston, Texas, U.S.A.

John H.Galla
University of Cincinnati College of Medicine
Cincinnati, Ohio, U.S.A.

Nicolaos E.Madias
Caritas St. Elizabeths Medical Center
Tufts University School of Medicine
Boston, Massachusetts, U.S.A

Boca Raton London New York Singapore

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Published in 2005 by
Taylor & Francis Group
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This edition published in the Taylor & Francis e-Library, 2006.

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International Standard Book Number-13: 978-0-8247-5915-5 (Print Edition) (Hardcover)

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In the middle of the last century, acid-base and electrolyte metabolism was perceived by medical students and physicians as a muddled and hopelessly complex field with few important clinical implications. Though names of notable early researchers such as Darrow, Singer, Hastings, Gamble, Peters, Davenport, Henderson, and Hasselbalch were recognized by many, their observations were not easily translated into a transparent form of physiology, pathophysiology, and clinical action. The elegant studies of many investigators, especially William B.Schwartz (our intellectual mentor), Donald W.Seldin, and Arnold S.Relman in the decades thereafter, dramatically enhanced the fundamental understanding of acid-base processes in humans and changed how the information was used in emergency departments, intensive care units, and ordinary hospital rooms. By the late 1970s and early 1980s, the and the use of the Henderson equation made caring for most patients with acid-base disorders more or less routine. With major discoveries such as confidence bands delineating the normal whole body responses to a primary change in PaCO2 or plasma bicarbonate concentration, the role of chloride, potassium, and volume in the development and correction of metabolic alkalosis, and the delineation of the various forms of metabolic acidosis, the acid-base mystery slowly evolved into the straightforward application of acid-base pathophysiology.

In the early 1980s, together with two of the editors of Acid-Base Disorders (Nicolaos E.Madias and F.John Gennari), we were the proud co-authors of Acid-Base, the first book devoted exclusively to the integration of basic acid-base physiology and explicit clinical applications. But the world of biological sciences has exploded again, and an extraordinary amount of information has accrued since, particularly at the cellular and molecular level. Acid-base retains its critical clinical importance because of two fundamental facts. First, characterization of the specific type of

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acid-base disorder can lead to appropriate therapy directly improving a patients outcome, and second, careful and rigorous analysis of a complex acid-base disorder can provide critical clues to detect underlying diseases.

The current cadre of editors, Horacio J.Adrogu, F.John Gennari, Nicolaos E.Madias, and John H.Galla, has created a rich, comprehensive book with the aid of some 26 authors from around the USA, Canada, and Europe. Acid-Base Disorders will be the basis for further research and clinical applications and the new encyclopedia of acid-base.

Jordan J.Cohen, M.D.
President, Association of American Medical Colleges

John T.Harrington, M.D.