Gunter Stein - Pathogenetic and Therapeutic Aspects of Chronic Renal Failure
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Pathogenetic and Therapeutic Aspects of Chronic Renal Failure
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Based on the proceedings of the International Workshop on Nephrology held recently in Berlin, Germany, this outstanding volume presents the latest research and clinical findings on the pathophysiology of chronic renal failure essential for the development of new therapeutic approaches.
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Friedrich-Schiller University of Jena Jena, Germany
MARCEL DEKKER, INC. NEW YORK BASEL HONG KONG
Page ii
ISBN: 0-8247-9894-5
The publisher offers discounts on this book when ordered in bulk quantities. For more information, write to Special Sales/Professional Marketing at the address below.
This book is printed on acid-free paper.
Copyright 1997 by Marcel Dekker, Inc. All Rights Reserved.
Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage and retrieval system, without permission in writing from the publisher.
Marcel Dekker, Inc. 270 Madison Avenue, New York, New York 10016 http://www.dekker.com
This book is based on an international workshop, Chronic Renal Failure: Pathogenetic and Therapeutic Aspects, held in Berlin in May 1996. The workshop addressed a number of issues of great relevance to our understanding of the pathophysiology of chronic renal failure, as well as to the development of new therapeutic approaches to delay its progress and treat its consequences.
The first part of the book deals with arterial hypertension, hyperlipidemia, and metabolic acidosis as factors that accelerate the progression of chronic renal failure and with the effect of dietary protein restriction as a measure to slow the advance of renal insufficiency.
The second part addresses the etiology and pathophysiology of myocardial hypertrophy in general, and especially in uremia, and the influence of the dialysis regimen on the development of myocardial hypertrophy.
The final section discusses the correction of renal anemia via treatment with recombinant human erythropoietin (rhEPO), with special emphasis on its effects on cardiac function and hypertrophy and on the function of parts of the endocrine system. Also included are an analysis of the use of rhEPO in renal-transplant patients and
Page iv
an overview of the problems of iron supplementation in rhEPO treatment.
We would like to express our thanks to the authors for their valuable and interesting contributions and to Boehringer Mannheim, Inc., for efficiently organizing this very informative and scientifically rewarding meeting.
K. M. KOCH GNTER STEIN
Page v
Contents
Preface
iii
Contributors
ix
Pathogenesis of Progression of Renal Insufficiency and Impact of Intervention
1. Relevance of Diet in the Progression of Renal Insufficiency
Saulo Klahr
1
2. Hypertension in Progressive Renal Disease
Johannes F. E. Mann, Karl F. Hilgers, Roland Veelken, and Isabelle Wolff
13
3. The Potential Role of Lipids in the Progression of Glomerular Diseases
Christoph J. Olbricht
21
4. Is Metabolic Acidosis a Risk Factor in the Progression of Renal Insufficiency?
F. John Gennari
33
Page vi
5. Diabetic Nephropathy
Trond D. Jenssen
45
Myocardial Hypertrophy
6. Etiology and Pathophysiology of Left Ventricular Hypertrophy
Franz H. Messerli and Leszek Michalewicz
55
7. Uremic Cardiomyopathy
Eberhard Ritz, Ute Schwartz, Michael Rambausek, and Kerstin Amann
83
8. Microalbumin and Cardiovascular Risk in Hypertension
Bhuwnesh Agrawal and Friedrich C. Luft
97
9. Improvement of Coronary Microcirculation by ACE Inhibitors
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