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Jack Fairweather - Clinical Companion in Nephrology

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Jack Fairweather Clinical Companion in Nephrology

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Jack Fairweather Mark Findlay and Christopher Isles Clinical Companion in - photo 1
Jack Fairweather , Mark Findlay and Christopher Isles
Clinical Companion in Nephrology
2nd ed. 2020
Jack Fairweather Renal and Transplant Unit Queen Elizabeth University - photo 2
Jack Fairweather
Renal and Transplant Unit, Queen Elizabeth University Hospital, Glasgow, UK
Mark Findlay
Renal and Transplant Unit, Queen Elizabeth University Hospital, Glasgow, UK
Christopher Isles
Dumfries and Galloway Royal Infirmary, Dumfries, UK
ISBN 978-3-030-38319-0 e-ISBN 978-3-030-38320-6
https://doi.org/10.1007/978-3-030-38320-6
Springer Nature Switzerland AG 2015, 2020
This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.
The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This Springer imprint is published by the registered company Springer Nature Switzerland AG

The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

Preface

It is a pleasure to produce our second edition of thisClinical Companion in Nephrology.

In 2015, we published edition one, a handbook for medical students and junior doctors aiming to demystify the nuances of renal medicine and provide an accessible knowledge base in clinical nephrology. Our feedback from edition one was clearshort, simple and easy-to-grasp explanations of common renal conditions were essential. The use of diagrams could not be underestimated, and the traditional ward-round teaching style of clinically relevant questions and answers was a positive. Using our readers feedback we have strived to improve this latest edition.

Firstly, we have maintained our original format of questions and answers, progressing from clinically applied anatomy and physiology through presentations of renal disease including haematuria, proteinuria and electrolyte disorders to more complex renal conditions. Much of the book remains devoted to AKI and CKD as the topics commonly managed by general physicians. We include a part on miscellaneous renal disease, covering topics from renal stone disease to pregnancy, and we have introduced additional chapters on the effect of renal disease on drugs and the effect of drugs on renal disease, in response to feedback. We devote a part to renal replacement therapy in a way that we hope will make clearer to non-nephrologists exactly what goes on inside dialysis and transplant units, and now discuss the role of dialysis in poisoning. As a concluding chapter, we introduce another new part, Practical Nephrology, where we explore the practical skills of nephrology, ranging from urinalysis to renal biopsy. And in response to the bewildered stares of medical students and junior doctors at biopsy meetings, we unveil our beginners guide to interpreting renal histopathology, Spotting the Glomerulus: Basics in Biopsy Interpretation. For this particular chapter, we are grateful for David Kipgens input.

Each chapter is now preceded with a best of five question, a format adopted by undergraduate and Royal College examinations where a clinical vignette is followed by five plausible answers, of which only one is the best option. This provides the reader with a bank of 50 questions over this book. Finally, to appeal to our visual learners, we have increased the number and altered the style of diagrams to mimic classroom notes.

Finally, we dedicate this work to our wives, Luisa, Maytal and Karen, for their tolerance and patience during the many evenings we spent drafting and redrafting this book. Again.

Jack Fairweather
Mark Findlay
Christopher Isles
Glasgow, UK Glasgow, UK Dumfries, UK
Abbreviations
(S)FLC

(Serum) free light chains

ABPM

Ambulatory blood pressure monitor

ACE

Angiotensin-converting enzyme

ACEi

Angiotensin-converting enzyme inhibitor

ACR

Albumin: creatinine ratio

ADH

Anti-diuretic hormone

ADPKD

Autosomal dominant polycystic kidney disease

aHUS

Atypical haemolytic uraemic syndrome

AKI

Acute kidney injury

ANA

Anti-nuclear antibody

ANCA

Anti-neutrophil cytoplasmic antibody

ANP

Atrial natriuretic peptide

Anti-GBM

Anti-glomerular basement membrane

APD

Automated peritoneal dialysis

ARB

Angiotensin II receptor blocker

ARVD

Atherosclerotic renovascular disease

ATN

Acute tubular necrosis

AV

Arteriovenous

BBV

Blood borne viruses

BC

Blood culture

bd

bis die (twice daily)

BJP

Bence Jones proteinuria

BP

Blood pressure

Ca

Calcium

CAPD

Continuous ambulatory peritoneal dialysis

CCB

Calcium channel blocker

CCD

Cortical collecting duct

CK

Creatine kinase

CKD

Chronic kidney disease

CM

Conservative management

CMV

Cytomegalovirus

CNI

Calcineurin inhibitor

CNS

Central nervous system

COPD

Chronic obstructive pulmonary disease

CRBSI

Catheter-related bloodstream infection

CRP

C-reactive protein

CT

Computed tomography

CXR

Chest X-ray

DBD

Donation following brain death

DCD

Donation following cardiac death

DCT

Distal convoluted tubule

ECF

Extracellular fluid

ECV

Extracellular volume

eGFR

Estimated glomerular filtration rate

EPO

Erythropoietin

ERF

Established renal failure (equivalent to end-stage renal failure/disease (ESRD))

ESA

Erythropoiesis-stimulating agent

ESBL

Extended-spectrum beta-lactamase

ESP

Encapsulating sclerosing peritonitis

FMD

Fibromuscular dysplasia

GFR

Glomerular filtration rate

GN

Glomerulonephritis

GPA

Granulomatous polyangiitis

GTN

Glyceryl trinitrate

Hb

Haemoglobin

HBc

Hepatitis B core

HBPM

Home blood pressure monitor

HBsAg

Hepatitis B surface antigen

HBV

Hepatitis B virus

HCV

Hepatitis C virus

HD

Haemodialysis

HELLP

Haemolysis, elevated liver enzymes, low platelets

HF

Heart failure

HIV

Human immunodeficiency

HLA

Human leukocyte antigens

HPT

Hyperparathyroidism

HR

Heart rate

HRS

Hepatorenal syndrome

HUS

Haemolytic uraemic syndrome

ICV

Intracellular volume

INR

International normalised ratio

IV

Intravenous

IVP

Intravenous pyelogram

K

Potassium

L of H

Loop of Henle

L

Litre

LMWH

Low molecular weight heparin

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