Coico Richard - Immunology: a short course

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Library of Congress Cataloging-in-Publication Data

Coico, Richard, author.

Immunology : a short course / Richard Coico, Geoffrey Sunshine. Seventh edition.

p. ; cm.

Includes bibliographical references and index.

ISBN 978-1-118-39691-9 (pbk.)

I. Sunshine, Geoffrey, author. II. Title.

[DNLM: 1. Allergy and Immunology. 2. Immune System Diseases. 3. Immune System Processes. 4. Immunity. QW 504]

QR181

616.079dc23

2014023101

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Cover image: Russell Kightley

Richard Coico is Professor of Cell Biology and Medicine and Vice Dean for Scientific Affairs at SUNY Downstate College of Medicine in New York. His major research interest concerns the study of the physiologic role of IgDa B-cell membrane immunoglobulin co-expressed with IgM. Another area of research concerns computational approaches to the identification of candidate vaccines for several hemorrhagic viruses, including Ebola and Lassa Fever viruses. He serves on several editorial boards including Current Protocols in Immunology.

Geoffrey Sunshine is a Senior Scientist at the Health Effects Institute in Boston, Massachusetts, which funds research worldwide on the health effects of air pollution. He is also a lecturer in the Tufts School of Medicine immunology course. For several years, he has directed a course in immunology for graduate dental students at Tufts University School of Dental Medicine and previously directed a course for veterinary students at Tufts University School of Veterinary Medicine. He was also a member of the Sackler School of Graduate Biomedical Sciences at Tufts University, doing research on antigen presentation and teaching immunology to medical graduate and undergraduate students.

As with our previous editions, the seventh edition of Immunology: A Short Course is intended to provide the reader with a clear and concise overview of our current understanding of the physiology of the immune system as well as the pathophysiology associated with various immune-mediated diseases. Although our knowledge of how the immune system develops and functions and the ways in which these physiological phenomena can fail or be compromised and thereby cause disease has significantly expanded since the previous edition, we have preserved our commitment to the motto less is more, the guiding light of this series. We are still committed to teaching our students and presenting to our readers only the information that we consider absolutely essential. To reflect this new knowledge, we have updated and rewritten every chapter in the sixth edition to incorporate new findings or to remove information that no longer reflects current thinking. We have also provided new multiple choice questions and answers at the end of each chapter so that the reader can evaluate his or her understanding. We have also made one other pivotal change as compared with earlier editions: At its most basic level, and since the first edition of the book, we have introduced the subject of immune response by highlighting the fact that it can be split into two arms: the innate response and the adaptive immune response. The past decade has witnessed the delineation of innate immunity in ways that have revolutionized our understanding of hostpathogen interactions and their impact on defense mechanisms in infectious diseases. Because of this growth in knowledge, we have added a new chapter on the subject of innate immunity ().