Creator - Physical Chemistry: Principles and Applications in Biological Sciences, Fifth Edition

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Principles and Applications in Biological Sciences

FIFTH EDITION

Ignacio Tinoco, Jr.

University of California, Berkeley

Kenneth Sauer

University of California, Berkeley

James C. Wang

Harvard University

Joseph D. Puglisi

Stanford University

Gerard Harbison

University of Nebraska, Lincoln

David Rovnyak

Bucknell University

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Cover Illustration courtesy of Gerard Harbison. Illustration created using Jmol: an open-source Java viewer for chemical structures in 3D. ( www.jmol.org )

Data obtained from the RCSB Protein Data Bank ( www.pdb.org ). H.M. Berman, J. Westbrook, Z. Feng, G. Gilliland, T.N. Bhat, H. Weissig, I.N. Shindyalov, P.E. Bourne (2000) The Protein Data Bank. Nucleic Acids Research, 28: 235242. Data files contained in the PDB archive include:

Top Structure: PDB ID 3CLN

Y. S. Babu, C. E. Bugg, W. J. Cook (1988) Structure of calmodulin refined at 2.2 A resolution. J. Mol. Biol. 204: 191204.

Middle Structure: PDB ID 1CM1

M.E. Wall, J. B. Clarage, G. N. Phillips Jr. (1997) Motions of calmodulin characterized using both Bragg and diffuse X-ray scattering. Structure 5: 15991612.

Bottom Structure: PDB ID 1CFD

H. Kuboniwa, N. Tjandra, S. Grzesiek, H. Ren, C. B. Klee, C.B., A. Bax (1995) Solution structure of calcium-free calmodulin. Nat. Struct. Biol. 2: 768776.

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Library of Congress Cataloging-in-Publication Data available upon request from Publisher.

1 2 3 4 5 6 7 8 9 10 EB 15 14 13 12

ISBN10: 0-13-605606-7; ISBN13: 978-0-13-605606-5

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There is a deep sense of pleasure to be experienced when the patterns and symmetry of nature are revealed. Physical chemistry provides the methods to discover and understand these patterns. We think that not only is it important to learn and apply physical chemistry to biological problems, it may even be fun. In this book, we have tried to capture some of the excitement of making new discoveries and finding answers to fundamental questions.

This is not an encyclopedia of physical chemistry. Rather, we have written this text specifically with the life-science student in mind. We present a streamlined treatment that covers the core aspects of biophysical chemistry (thermodynamics and kinetics as well as quantum mechanics, spectroscopy, and X-ray diffraction), which are of great importance to students of biology and biochemistry. Essentially all applications of the concepts are systems of interest to life-science students; nearly all the problems apply to life-science examples.

For the fifth edition, we have extensively revised and updated the treatment of biophysical chemistry, bringing in theoretical approaches earlier and also updating the text to current IUPAC conventions. We have added a new chapter on electrochemistry and expanded our treatment of single molecule methods, quantum mechanics, and magnetic resonance.