Landmarks
Clinical Chemistry
ENHANCED EIGHTH EDITION
Principles, Techniques,
and Correlations
Clinical Chemistry
ENHANCED EIGHTH EDITION
Principles, Techniques,
and Correlations
Michael L. Bishop, MS, MLS(ASCP)CM
Campus Department Chair
Medical Laboratory Science
Keiser University
Orlando, Florida
Edward P. Fody, MD
Clinical Professor
Department of Pathology, Microbiology and Immunology
Vanderbilt University School of Medicine
Nashville, Tennessee
Medical Director
Department of Pathology
Holland Hospital
Holland, Michigan
Larry E. Schoeff, MS, MT(ASCP)
Professor (Retired), Medical Laboratory Science Program
Department of Pathology
University of Utah School of Medicine
Salt Lake City, Utah
JONES & BARTLETT
LEARNING
World Headquarters
Jones & Bartlett Learning
25 Mall Road, Suite 600
Burlington, MA 01803
978-443-5000
www.jblearning.com
Jones & Bartlett Learning books and products are available through most bookstores and online booksellers. To contact Jones & Bartlett Learning directly, call 800-832-0034, fax 978-443-8000, or visit our website, www.jblearning.com.
Substantial discounts on bulk quantities of Jones & Bartlett Learning publications are available to corporations, professional associations, and other qualified organizations. For details and specific discount information, contact the special sales department at Jones & Bartlett Learning via the above contact information or send an email to .
Copyright 2018 by Jones & Bartlett Learning, LLC, an Ascend Learning Company
All rights reserved. No part of the material protected by this copyright may be reproduced or utilized in any form, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without written permission from the copyright owner.
The content, statements, views, and opinions herein are the sole expression of the respective authors and not that of Jones & Bartlett Learning, LLC. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise does not constitute or imply its endorsement or recommendation by Jones & Bartlett Learning, LLC and such reference shall not be used for advertising or product endorsement purposes. All trademarks displayed are the trademarks of the parties noted herein. Clinical Chemistry: Prinicples, Techniques, and Correlations, Enhanced Eighth Edition is an independent publication and has not been authorized, sponsored, or otherwise approved by the owners of the trademarks or service marks referenced in this product.
There may be images in this book that feature models; these models do not necessarily endorse, represent, or participate in the activities represented in the images. Any screenshots in this product are for educational and instructive purposes only. Any individuals and scenarios featured in the case studies throughout this product may be real or fictitious but are used for instructional purposes only.
This publication is designed to provide accurate and authoritative information in regard to the Subject Matter covered. It is sold with the understanding that the publisher is not engaged in rendering legal, accounting, or other professional service. If legal advice or other expert assistance is required, the service of a competent professional person should be sought.
51015-7
Production Credits
VP, Product Management: Amanda Martin
Director of Product Management: Cathy Esperti
Product Manager: Sean Fabery
Product Specialist: Andrew LaBelle
Product Coordinator: Elena Sorrentino
Digital Project Specialist: Angela Dooley
Director of Marketing: Andrea DeFronzo
Marketing Manager: Suzy Balk
Production Services Manager: Colleen Lamy
VP, Manufacturing and Inventory Control: Therese Connell
Composition: S4Carlisle Publishing Services
Project Management: S4Carlisle Publishing Services
Cover Design: Kristin E. Parker
Rights Specialist: Rebecca Damon
Printing and Binding: LSC Communications
Library of Congress Cataloging-in-Publication Data
Library of Congress Cataloging-in-Publication Data unavailable at time of printing.
LCCN: 2020936069
6048
Printed in the United States of America
25 24 23 22 21 10 9 8 7 6 5 4 3 2
In memory of my mother, Betty Beck Bishop, for her constant support, guidance, and encouragement.
MLB
To Nancy, my wife, for continuing support and dedication.
EPF
To my wife, Anita, for continuing support.
LES
contributors
Dev Abraham, MD
Professor of Medicine
Division of Endocrinology
University of Utah
Salt Lake City, Utah
Josephine Abraham, MD, MPH
Professor of Medicine
Division of Nephrology
University of Utah
Salt Lake City, Utah
Michael J. Bennett, PHD, FRCPATH, FACB, DABCC
Professor of Pathology and Laboratory Medicine
University of Pennsylvania
Director, Metabolic Disease Laboratory
Childrens Hospital of Philadelphia
Abramson Pediatric Research Center
Philadelphia, Pennsylvania
Takara L. Blamires, M.S., MLS(ASCP)CM
Medical Laboratory Science Program
Department of Pathology
University of Utah School of Medicine
Salt Lake City, Utah
Maria G. Boosalis, PHD, MPH, RD, LD
Professor, College of Health and Wellness
Northwestern Health Sciences University
Bloomington, Minnesota
Raffick A. R. Bowen, PHD, MHA, MT(CSMLS), DCLCHEM, FCACB, DABCC, FACB
Clinical Associate Professor of Pathology
Associate Director of Clinical Chemistry and Immunology Laboratory
Department of Pathology
Stanford Health Care
Stanford, California
Janelle M. Chiasera, PHD
Department Chair, Clinical and Diagnostic Sciences
University of Alabama Birmingham
Birmingham, Alabama
Heather Corn, MD
Internal Medicine Clinical Instructor
Endocrinology and Diabetes Center
University of Utah
Salt Lake City, Utah
Heather Crookston, PHD
Point of Care Coordinator
Nemours Childrens Hospital
Orlando, Florida
Julia C. Drees, PHD, DABCC
Clinical Research and Development Scientist
Kaiser Permanente Regional Laboratory
Berkeley, California
Kathryn Dugan, MED, MT(ASCP)
Instructor Medical and Clinical Laboratory Sciences
Auburn University at Montgomery
Montgomery, Alabama
Michael Durando, MD, PHD
Research Track Resident, Internal Medicine and Hematology/Oncology
Emory University
Atlanta, Georgia
Edward P. Fody, MD
Clinical Professor
Department of Pathology, Microbiology and Immunology
Vanderbilt University School of Medicine
Nashville, Tennessee
Medical Director
Department of Pathology
Holland Hospital