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Marc S. Sabatine - Pocket Medicine: The Massachusetts General Hospital Handbook of Internal Medicine

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Marc S. Sabatine Pocket Medicine: The Massachusetts General Hospital Handbook of Internal Medicine
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Senior Acquisitions Editor Sharon Zinner Development Editor Ashley Fischer - photo 1

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Senior Acquisitions Editor: Sharon Zinner

Development Editor: Ashley Fischer

Production Project Manager: Sadie Buckallew

Editorial Coordinator: Ingrid Greenlee

Manufacturing Coordinator: Kathy Brown

Design Coordinator: Stephen Druding

Prepress Vendor: S4Carlisle Publishing Services

Copyright 2020, 2017, 2014, 2011, 2008, 2004, 2000 by Wolters Kluwer

All rights reserved. This book is protected by copyright. No part of this book may be reproduced in any form by any means, including as photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. To request permission, please contact Wolters Kluwer at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at (products and services).

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Printed in Mexico

Library of Congress Cataloging-in-Publication Data

ISBN-13: 978-1-975142-37-7

ISBN-10: 1-975142-37-3

eISBN: 978-1-975142-39-1

Library of Congress Control Number: 2019908668

This work is provided as is, and the publisher disclaims any and all warranties, express or implied, including any warranties as to accuracy, comprehensiveness, or currency of the content of this work.

This work is no substitute for individual patient assessment based upon healthcare professionals examination of each patient and consideration of, among other things, age, weight, gender, current or prior medical conditions, medication history, laboratory data and other factors unique to the patient. The publisher does not provide medical advice or guidance and this work is merely a reference tool. Healthcare professionals, and not the publisher, are solely responsible for the use of this work including all medical judgments and for any resulting diagnosis and treatments.

Given continuous, rapid advances in medical science and health information, independent professional verification of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options should be made and healthcare professionals should consult a variety of sources. When prescribing medication, healthcare professionals are advised to consult the product information sheet (the manufacturers package insert) accompanying each drug to verify, among other things, conditions of use, warnings and side effects and identify any changes in dosage schedule or contraindications, particularly if the medication to be administered is new, infrequently used or has a narrow therapeutic range. To the maximum extent permitted under applicable law, no responsibility is assumed by the publisher for any injury and/or damage to persons or property, as a matter of products liability, negligence law or otherwise, or from any reference to or use by any person of this work.

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CONTENTS

Rachel Frank, Shilpa Sharma, Nino Mihatov, Nilay Patel, Marc S. Sabatine, Michelle L. ODonoghue

Miranda Theodore, Jason Maley, Walter J. ODonnell

Stephanie M. Rutledge, Emily Walsh Lopes, Lawrence S. Friedman

Alexander Blair, Harish Seethapathy, Andrew S. Allegretti

Melissa Lumish, Arielle Medford, Tanya E. Keenan, Harshabad Singh, Jean M. Connors, Daniel J. DeAngelo, David P. Ryan

Alison C. Castle, Kristen Hysell, Kimon C. Zachary

Caitlin Colling, Armen Yerevanian, Michael Mannstadt

Isaac D. Smith, Mazen Nasrallah, Robert P. Friday

Omar Al-Louzi, Leeann Brigham Burton, Kristin Galetta, Morgan Prust, Michael P. Bowley

Sarah J. Carlson, Jennifer F. Tseng, Katherine T. Chen, Stella K. Kim

Andrew S. Allegretti, MD, MSc

Director of ICU Nephrology, Attending Physician, Nephrology Division, and Principal Investigator, Kidney Research Center, Massachusetts General Hospital

Instructor of Medicine, Harvard Medical School

Omar Al-Louzi, MD

Neurology Resident, Partners Neurology Residency

Alexander Blair, MD

Internal Medicine Resident, Massachusetts General Hospital

Michael P. Bowley, MD, PhD

Instructor in Neurology, Massachusetts General Hospital

Associate Program Director, Partners Neurology Residency Program

Leeann Brigham Burton, MD

Neurology Resident, Partners Neurology Residency

Sarah J. Carlson

Assistant Professor of Surgery, Boston University of Medicine

Attending Surgeon, Boston Veterans Affairs Healthcare

Alison C. Castle, MD

Internal Medicine Resident, Massachusetts General Hospital

Katherine T. Chen, MD, MPH

Vice-Chair of Ob/Gyn Education, Career Development, and Mentorship

Professor of Obstetrics, Gynecology, and Reproductive Science

Professor of Medical Education

Icahn School of Medicine at Mount Sinai, New York

Caitlin Colling, MD

Internal Medicine Resident, Massachusetts General Hospital

Jean M. Connors, MD

Medical Director, Anticoagulation Management Services

Hematology Division, Brigham and Womens Hospital & Dana-Farber Cancer Institute

Associate Professor of Medicine, Harvard Medical School

Daniel J. DeAngelo, MD, PhD

Chief of the Division of Leukemia, Dana-Farber Cancer Institute

Professor of Medicine, Harvard Medical School

Rachel Frank, MD

Internal Medicine Resident, Massachusetts General Hospital

Robert P. Friday, MD, PhD

Chief, Division of Rheumatology, Newton-Wellesley Hospital

Affiliate Physician, Rheumatology Unit, Massachusetts General Hospital

Instructor in Medicine, Harvard Medical School

Lawrence S. Friedman, MD

The Anton R. Fried, MD, Chair, Department of Medicine, Newton-Wellesley Hospital

Assistant Chief of Medicine, Massachusetts General Hospital

Professor of Medicine, Harvard Medical School

Professor of Medicine, Tufts University School of Medicine

Kristin Galetta, MD

Neurology Resident, Partners Neurology Residency

Kristen Hysell, MD

Infectious Disease Fellow, Massachusetts General Hospital

Tanya E. Keenan, MD, MPH

Hematology-Oncology Fellow, Dana-Farber/Partners CancerCare

Stella K. Kim, MD

Joe M. Green Jr. Professor of Clinical Ophthalmology

Ruiz Department of Ophthalmology and Visual Sciences

Robert Cizik Eye Clinic

University of Texas McGovern School of Medicine

Emily Walsh Lopes, MD

Gastroenterology Fellow, Massachusetts General Hospital

Melissa Lumish, MD

Internal Medicine Resident, Massachusetts General Hospital

Jason Maley, MD

Pulmonary Fellow, Massachusetts General Hospital

Michael Mannstadt, MD

Chief, Endocrine Unit, Massachusetts General Hospital

Associate Professor of Medicine, Harvard Medical School

Arielle Medford, MD

Internal Medicine Resident, Massachusetts General Hospital

Nino Mihatov, MD

Cardiology Fellow, Massachusetts General Hospital

Mazen Nasrallah, MD, MSc

Rheumatology Fellow, Massachusetts General Hospital

Walter J. ODonnell, MD

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