Marc S. Sabatine MD MPH - Pocket Cardiology

Editor

Authors

Executive Editor: Rebecca Gaertner

Senior Product Development Editor: Kristina Oberle

Production Project Manager: Bridgett Dougherty

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Design Coordinator: Teresa Mallon

Production Service: Aptara, Inc.

2016 by Wolters Kluwer Health

All rights reserved. This book is protected by copyright. No part of this book may be reproduced or transmitted in any form or by any means, including as photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. To request permission, please contact Wolters Kluwer at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at (products and services).

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Library of Congress Cataloging-in-Publication Data

Pocket cardiology : a companion to Pocket medicine / editor, Marc S. Sabatine; authors,

Marc P. Bonaca, Gregory D. Lewis, Michelle L. ODonoghue, Usha B. Tedrow.

p.; cm. (Pocket notebook)

Includes index.

ISBN 978-1-4511-9188-2 (alk. paper)

I. Sabatine, Marc S., editor. II. Pocket medicine. 5th edition. Complemented by (work): III. Series: Pocket notebook.

[DNLM: 1. Cardiovascular DiseasesHandbooks. WG 39]

RC55

616dc23

2015032058

This work is provided as is, and the publisher disclaims any and all warranties, express or implied, including any warranties as to accuracy, comprehensiveness, or currency of the content of this work.

This work is no substitute for individual patient assessment based upon healthcare professionals examination of each patient and consideration of, among other things, age, weight, gender, current or prior medical conditions, medication history, laboratory data and other factors unique to the patient. The publisher does not provide medical advice or guidance and this work is merely a reference tool. Healthcare professionals, and not the publisher, are solely responsible for the use of this work including all medical judgments and for any resulting diagnosis and treatments.

Given continuous, rapid advances in medical science and health information, independent professional verification of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options should be made and healthcare professionals should consult a variety of sources. When prescribing medication, healthcare professionals are advised to consult the product information sheet (the manufacturers package insert) accompanying each drug to verify, among other things, conditions of use, warnings and side effects and identify any changes in dosage schedule or contraindications, particularly if the medication to be administered is new, infrequently used or has a narrow therapeutic range. To the maximum extent permitted under applicable law, no responsibility is assumed by the publisher for any injury and/or damage to persons or property, as a matter of products liability, negligence law or otherwise, or from any reference to or use by any person of this work.

LWW.com

Marc P. Bonaca, MD, MPH

Investigator, TIMI Study Group

Associate Physician, Division of Cardiovascular Medicine, Brigham and Womens Hospital

Instructor in Medicine, Harvard Medical School

Gregory D. Lewis, MD

Director, Cardiology Intensive Care Unit; Director, Cardiopulmonary Exercise Laboratory; Medical Director, Mechanical Circulatory Support Program

Associate Physician, Cardiovascular Division, Massachusetts General Hospital

Assistant Professor of Medicine, Harvard Medical School

Michelle L. ODonoghue, MD, MPH

Investigator, TIMI Study Group

Associate Physician, Division of Cardiovascular Medicine, Brigham and Womens Hospital

Affiliate Physician, Cardiology Division, Massachusetts General Hospital

Assistant Professor of Medicine, Harvard Medical School

Marc S. Sabatine, MD, MPH

Chairman, TIMI Study Group

Lewis Dexter, MD Distinguished Chair in Cardiovascular Medicine, Brigham and Womens Hospital

Affiliate Physician, Cardiology Division, Massachusetts General Hospital

Professor of Medicine, Harvard Medical School

Usha B. Tedrow, MD, MS

Director, Clinical Cardiac Electrophysiology Program

Director, Women and Arrhythmias Program

Physician, Division of Cardiovascular Medicine, Brigham and Womens Hospital

Associate Professor of Medicine, Harvard Medical School

With Pocket Cardiology, we now offer those taking care of patients with complex cardiovascular disease a focused and concise reference to aid them in their daily clinical care. Pocket Cardiology has been designed to either supplant the Cardiology section in Pocket Medicine or serve as a stand-alone handbook. Pocket Cardiology provides greatly expanded coverage of the latest treatment options for the major common cardiovascular diseases as well as new sections on advanced heart failure, vascular, and electrophysiology topics.

We have incorporated key references to the most recent high-tier reviews and important studies published right up to the time Pocket Cardiology went to press. We welcome any suggestions for further improvement. Although the recommendations herein are as evidence based as possible, sound clinical judgement must be applied to every scenario.

This book would not have been possible without the help of Melinda Cuerda, who shepherded the project from start to finish, with an incredible eye to detail to ensure that each page of this book was the very best it could be.

It is a privilege to take care of patients, especially when working with the house officers, fellows, and attendings at Brigham and Womens Hospital and the Massachusetts General Hospital. The rapid advances in cardiovascular medicine are truly amazing. We hope the information contained within Pocket Cardiology proves useful in your quest to deliver the best possible care to your patients.

M ARC S. S ABATINE, MD, MPH