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Marc S. Sabatine MD - Pocket Medicine: The Massachusetts General Hospital Handbook of Internal Medicine

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Prepared by residents and attending physicians at Massachusetts General Hospital, the 5th edition of Pocket Medicine: The Massachusetts General Hospital Handbook of Internal Medicine provides key clinical information and solutions to common problems faced in the practice of internal medicine.Designed to fit in a pocket, this 6-ring looseleaf binder tackles the diagnosis and treatment of the most common disorders in cardiology, pulmonary medicine, gastroenterology, nephrology, hematology-oncology, infectious diseases, endocrinology, rheumatology, and neurology.Bulleted lists combined with tables and algorithms allow busy clinicians to find the information they need rapidly. A 16-page color insert displays classic normal and abnormal radiographs, CT scans, echocardiograms, peripheral blood smears, and urinalyses seen in the practice of internal medicine.Completely updated, this highly regarded, best-selling reference is ideal for medical students, interns, residents, and candidates reviewing for internal medicine board exams.FEATURES:
User-friendly 2-color design
Small enough to fit in a pocket
6-ring binder to accommodate notes
Tabs help locate major organ systems quickly
Content has been fully updated to include the most recent information across the full breadth of inpatient internal medicine.

If you purchased a copy of Sabatine: Pocket Medicine 5e, ISBN 978-1-4511-8237-8, please make note of the following important correction on page 1-36:

Oral anticoagulation (Chest 2012;141:e531S; EHJ 2012;33:2719; Circ 2013;127:1916)

All valvular AF as stroke risk very high

Nonvalv. AF: stroke risk ~4.5%/y; anticoag 68% stroke; use a risk score to guide Rx:

CHADS2: CHF (1 point), HTN (1), Age 75 y (1), DM (1), prior Stroke/TIA (2)

CHA2DS2-VASc: adds 6574 y (1) 75 y (2), vasc dis. [MI, Ao plaque, or PAD (1)]; ? (1)

score2anticoag; score 1consider anticoag or ASA (? latter reasonable if risk factor age 65-74 y, vasc dis. or ?); antithrombotic Rx even if rhythm control [SCORE CORRECTED]

Rx options: factor Xa or direct thrombin inhib (non-valv only; no monitoring required) or
warfarin (INR 2-3; w/ UFH bridge if high risk of stroke); if Pt refuses anticoag, consider

ASA + clopi or, even less effective, ASA alone (NEJM 2009;360:2066)

Please make note of this correction in your copy of Sabatine: Pocket Medicine 5e immediately and contact LWWs Customer Service Department at 1.800.638.3030 or 1.301.223.2300 so that you may be issued a corrected page 1-36. You may also download a PDF of page 1-36 directly from www.lww.com/PocketMedicine.

All copies of Pocket Medicine, 5e with the ISBN: 978-1-4511-9378-7 include this correction.

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Pocket M EDICINE Fifth Edition Edited by M ARC S S ABATINE MD MPH A - photo 1

Pocket
M EDICINE
Fifth Edition

Edited by

M ARC S. S ABATINE , MD, MPH
A SSOCIATE P ROFESSOR OF M EDICINE
H ARVARD M EDICAL S CHOOL

The Massachusetts General Hospital Handbook of Internal Medicine Health - photo 2

The Massachusetts General Hospital
Handbook of Internal Medicine

Health Philadelphia Baltimore New York London Buenos Aires Hong Kong Sydney - photo 3

Health

Philadelphia Baltimore New York London

Buenos Aires Hong Kong Sydney Tokyo

Executive Editor: Rebecca Gaertner
Product Manager: Kristina Oberle
Vendor Manager: Bridgett Dougherty
Manufacturing Coordinator: Beth Welsh
Marketing Manager: Kim Schonberger
Creative Director: Doug Smock
Production Service: Aptara, Inc.

2014 by LIPPINCOTT WILLIAMS & WILKINS, a WOLTERS KLUWER business
Two Commerce Square
2001 Market Street
Philadelphia, PA 19103 USA
LWW.com

All rights reserved. This book is protected by copyright. No part of this book may be reproduced in any form by any means, including photocopying, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright.

Printed in China

Not authorised for sale in United States, Canada, Australia, New Zealand, Puerto Rico, and United States Virgin Islands.

Library of Congress Cataloging-in-Publication Data

Pocket medicine (Sabatine)

Pocket medicine / [edited by] Marc S. Sabatine. Fifth edition.

p. ; cm.

Preceded by Pocket medicine / edited by Marc S. Sabatine. 4th ed.
c2011.

Includes bibliographical references and index.

ISBN-13: 978-1-4511-8237-8

ISBN-10: 1-4511-8237-6

ISBN-13: 978-1-4511-8887-5

ISBN-10: 1-4511-8887-0

I. Sabatine, Marc S., editor of compilation. II. Title.

[DNLM: 1. Internal MedicineHandbooks. 2. Clinical MedicineHandbooks. WB 39]

RC55

616dc23

2013019655

DISCLAIMER Care has been taken to confirm the accuracy of the information presented and to describe generally accepted practices. However, the authors, editors, and publisher are not responsible for errors or omissions or for any consequences from application of the information in this book and make no warranty, expressed or implied, with respect to the currency, completeness, or accuracy of the contents of the publication. Application of the information in a particular situation remains the professional responsibility of the practitioner.

The authors, editors, and publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accordance with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new or infrequently employed drug.

Some drugs and medical devices presented in the publication have Food and Drug Administration (FDA) clearance for limited use in restricted research settings. It is the responsibility of the health care provider to ascertain the FDA status of each drug or device planned for use in their clinical practice.

To purchase additional copies of this book, call our customer service department at (800) 638-3030 or fax orders to (301) 223-2320. International customers should call (301) 223-2300.

Visit Lippincott Williams & Wilkins on the Internet: at LWW.com. Lippincott Williams & Wilkins customer service representatives are available from 8:30 am to 6 pm, EST.

10 9 8 7 6 5 4 3 2 1

CONTENTS

Neal A. Chatterjee, Ada Stefanescu, William J. Hucker, David M. Dudzinski, Marc S. Sabatine, Michelle ODonoghue

Ian J. Barbash, Kathryn A. Hibbert, Atul Malhotra

Zachary A. Zator, Andrew S. de Lemos, Lawrence S. Friedman

Andrew S. Allegretti, Andrew L. Lundquist, Hasan Bazari

Andrew M. Brunner, Sheheryar K. Kabraji, Mark M. Awad, Andrew J. Aguirre, Daniel J. DeAngelo, David P. Ryan

Ana A. Weil, Emily P. Hyle, Nesli Basgoz

KellyB. Lauter, Marc N. Wein, Michael Mannstadt

Zachary S. Wallace, Eli Miloslavsky, Robert P. Friday

Michael P. Bowley, Todd M. Herrington, Eyal Y. Kimchi, Sarah Wahlster, Tracey A. Cho

Kiran H. Lagisetty, Jennifer F. Tseng, Katherine T. Chen, Stella K. Kim

CONTRIBUTING AUTHORS

Andrew J. Aguirre, MD, PhD

Hematology-Oncology Fellow, Dana-Farber/Partners CancerCare Hematology/Oncology Program

Andrew S. Allegretti, MD

Internal Medicine Resident, Massachusetts General Hospital

Mark M. Awad, MD, PhD

Hematology-Oncology Fellow, Dana-Farber/Partners CancerCare Hematology/Oncology Program

Ian J. Barbash, MD

Internal Medicine Resident, Massachusetts General Hospital

Nesli Basgoz, MD

Associate Chief and Clinical Director, Infectious Disease Division, Massachusetts General Hospital

Associate Professor of Medicine, Harvard Medical School

Hasan Bazari, MD

Clinical Director, Nephrology Unit, Massachusetts General Hospital

Program Director, Internal Medicine Residency, Massachusetts General Hospital

Associate Professor of Medicine, Harvard Medical School

Michael P. Bowley, MD, PhD

Neurology Resident, Partners Neurology Residency

Andrew M. Brunner, MD

Internal Medicine Resident, Massachusetts General Hospital

Neal A. Chatterjee, MD

Internal Medicine Resident, Massachusetts General Hospital

Katherine T. Chen, MD, MPH

Associate Professor of Obstetrics, Gynecology, and Reproductive Science

Associate Professor of Medical Education

Vice-Chair of Ob/Gyn Education, Career Development, and Mentorship

Icahn School of Medicine at Mount Sinai, New York

Tracey A. Cho, MD

Associate Program Director, Partners-Harvard Neurology Residency

Assistant Professor of Neurology, Harvard Medical School

Assistant Neurologist, Massachusetts General Hospital

Andrew S. de Lemos, MD

Transplant Hepatology Fellow, Massachusetts General Hospital

Daniel J. DeAngelo, MD, PhD

Adult Leukemia Program, Dana-Farber Cancer Institute & Brigham and Womens Hospital

Associate Professor of Medicine, Harvard Medical School

David M. Dudzinski, MD, JD

Cardiology Fellow, Massachusetts General Hospital

Robert P. Friday, MD, PhD

Attending Physician, Rheumatology Unit, Massachusetts General Hospital

Associate Director, Rheumatology Fellowship Program, Massachusetts General Hospital

Instructor in Medicine, Harvard Medical School

Lawrence S. Friedman, MD

Anton R. Fried, MD, Chair, Department of Medicine, Newton-Wellesley Hospital

Assistant Chief of Medicine, Massachusetts General Hospital

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