Wanda M. Haschek - Haschek and Rousseauxs Handbook of Toxicologic Pathology, Second Edition
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- Book:Haschek and Rousseauxs Handbook of Toxicologic Pathology, Second Edition
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This two-volume set provides the reader with a single reference for toxicologic pathology. In volume I, the book covers toxicologic pathology in its basic aspects, including its definition, the basic biochemical and morphologic mechanisms underlying the discipline, the basic practice of toxicologic pathology (including special techniques) and issues essential to the understanding of toxicologic pathology such as risk assessment, experimental design, and statistical analysis. Next, the book moves to specific issues affecting the practice toxicologic pathology, including issues such as knowledge management, regulatory affairs and writing pathology reports. Finally, Volume I closes with several chapters that deal with specific classes of environmental toxicants such as endocrine disruptors and heavy metals. Volume II addresses the toxicologic pathology in a thoroughly standardized systems manner, addressing the basic structure and function of a particular organ system, its response to toxic injury, mechanisms of injury and methods of evaluation of such injury.
Key Features
* Easy to find, up-to-date reference information
* Graphic and photographic plates
* Current hot topics and anticipated changes in toxicologic pathology
* Standardized chapter format
* Topics that are addressed in both a broad and deep manner, resulting in a stand alone text
* Added coverage of important environmental toxicants
* Chapters authored by internationally recognized experts and peer-reviewed
Wanda M. Haschek: author's other books
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Volume 1, Second Edition
WANDA M. HASCHEK
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois
COLIN G. ROUSSEAUX
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada
MATTHEW A. WALLIG
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois
This book is printed on acid-free paper. 
Copyright 2002, 1991 by ACADEMIC PRESS
All Rights Reserved.
No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher.
Requests for permission to make copies of any part of the work should be mailed to:
Permissions Department, Harcourt Inc., 6277 Sea Harbor Drive,
Orlando, Florida 32887-6777
Academic Press
A Harcourt Science and Technology Company
525 B Street, Suite 1900, San Diego, California 92101-4495, USA
http://www.academicpress.com
Academic Press
Harcourt Place, 32 Jamestown Road, London NW1 7BY, UK
http://www.academicpress.com
Library of Congress Catalog Card Number: 2001088191
International Standard Book Number: 0-12-330215-3 (set)
International Standard Book Number: 0-12-330216-1 (volume 1)
International Standard Book Number: 0-12-330217-X (volume 2)
PRINTED IN THE UNITED STATES OF AMERICA
010203040506MM987654321
The editors dedicate this book to their parents, Maria U. and Karol A. Haschek (deceased, 1999), Francesca and Georges E. Rousseaux (deceased, 1993), Marian B. and Thomas V. Wallig, and all other individuals who have supported us in our lifes endeavors, encouraged us when needed, mentored us in our learning, and inspired us in our educational pursuits for the betterment of society.
Numbers in parentheses indicate the volume and pages on which the authors contributions begin.
Global Metabolism and Investigative Sciences, Pharmacia, St. Louis, Missouri 63167
Department of Veterinary Biosciences, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802
Department of Pathology, Colorado State University, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, Colorado 80523
Central Research Division, Pfizer Inc., Groton, Connecticut 06340
Hugh E. Black & Associates, Inc., Sparta, New Jersey 07871
Kinsmen Childrens Centre and Department of Pediatrics, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 0W8
Amgen, Thousands Oaks, California 91320
GlobalTox International Consultants Inc., Guelph, Ontario, Canada N1H 7K9
IDDEX, Portland, Oregon
Pathology Associates International, National Center for Toxicological Research, Jefferson, Arkansas 72079
Drug Safety Department, Pfizer, Inc., Global Research and Development, Groton, Connecticut 06348
Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210
Department of Discovery Toxicology, DuPont Pharmaceuticals Company, Newark, Delaware 19714
Amgen Inc., Thousand Oaks, California 91320
Sierra Biomedical, A Division of Charles River Laboratories, Inc., Sparks, Nevada 89431
Environmental and Occupational Toxicology Division, Bureau of Chemical Hazards, Health and Welfare Canada, Ottawa, Ontario, Canada K1H 8M5
Department of Discovery Toxicology, DuPont Pharmaceuticals Company, Newark, Delaware 19714
Department of Pathology/Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, Nebraska 68198
Department of Discovery Toxicology, DuPont Pharmaceuticals Company, Newark, Delaware 19714
Department of Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Smithville, Texas 78957
Department of Veterinary Biosciences, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802
Huntingdon Life Sciences, East Millstone, New Jersey 08875
Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201
Department of Pathology, New York Hospital, Cornell Medical Center, New York, New York
CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709
Discovery Safety Optimization, Bristol-Myers Squibb PRI, Princeton, New Jersey 08543
CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709
Sierra Biomedical, A Division of Charles River Laboratories, Inc., Sparks, Nevada 89431
Ultrastructure Section, Pathology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
Department of Drug Safety Evaluation, Pfizer Nagoya Laboratories, Taketoyo, Aichi 4702393, Japan
Frontline Corporate Communications Inc., Kitchener, Ontario, Canada N2H 6M6
Drug Safety Evaluation, Pfizer Global Research & Development, Groton, Connecticut 06348
CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709
First Department of Pathology, Osaka City University Medical School, Osaka 545, Japan
Gad Consulting Services, Raleigh, North Carolina 27511
Sierra Biomedical, A Division of Charles River Laboratories, Inc., Sparks, Nevada 89431
Department of Veterinary Pathology, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana 70803
Department of Veterinary Anatomy and Cell Biology, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana 70803
ASPCA, National Animal Poison Control Center, Urbana, Illinois 61802
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87185
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
Covance Laboratories, Madison, Wisconsin 53704
Experimental Pathology Laboratories, Inc., Research Triangle Park, North Carolina 27709
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802
Department of Pathology, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
Division of Drug Biology, Food and Drug Administration, Washington, D.C. 20204
Department of Veterinary Biosciences, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802
Department of Biological Sciences, The University of Alabama, and Ronald D. Hood & Associates, Toxicology Consultants, Tuscaloosa, Alabama 35487
Division of Radiobiology, University of Utah, Salt Lake City, Utah 84108
Department of Food Science and Human Nutrition, Department of Veterinary Biosciences and College of Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802
Pathology Associates International, Durham, North Carolina
Global Toxicology, Pharmacia, Skokie, Illinois 60077
Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
TNO Nutrition and Food Research, 3704 HE Zeist, The Netherlands
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