Heather F. Sateia - The Washington Manual of Outpatient Internal Medicine

Executive Editor

Thomas M. De Fer, MD

Professor of Medicine
Director, Internal Medicine Clerkship and the ACES Program
Division of Medical Education, Department of Medicine
Washington University School of Medicine
Saint Louis, Missouri

Editor

Heather F. Sateia, MD

Instructor of Medicine
Division of Medical Education, Department of Medicine
Washington University School of Medicine
Saint Louis, Missouri

Executive Editor: Rebecca S. Gaertner

Product Development Editor: Kristina Oberle

Editorial Coordinator: Katie Sharp

Marketing Manager: Stephanie Kindlick

Production Project Manager: Bridgett Dougherty

Design Coordinator: Teresa Mallon

Manufacturing Coordinator: Beth Welsh

Prepress Vendor: SPi Global

Second edition

Copyright 2015, 2010 by Department of Medicine, Washington University School of Medicine

All rights reserved. This book is protected by copyright. No part of this book may be reproduced or transmitted in any form or by any means, including as photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. To request permission, please contact Wolters Kluwer at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at (products and services).

9 8 7 6 5 4 3 2 1

Printed in China

Library of Congress Cataloging-in-Publication Data

The Washington manual of outpatient internal medicine / [executive editor] Thomas M. De Fer ; editor, Heather Sateia. Second edition.

p. ; cm.

Manual of outpatient internal medicine

Complemented by: Washington manual of medical therapeutics.

Includes bibliographical references and index.

ISBN 978-1-4511-4327-0 (alk. paper)

I. De Fer, Thomas M., editor.II. Sateia, Heather F., editor.III. Washington University (Saint Louis, Mo.). Department of Medicine, issuing body.IV. Washington manual of medical therapeutics. Complemented by (work):V. Title: Manual of outpatient internal medicine.

[DNLM:1. Ambulatory CareHandbooks.2. Internal MedicinemethodsHandbooks. WB 39]

RC55

362.12dc23

2014048408

This work is provided as is, and the publisher disclaims any and all warranties, express or implied, including any warranties as to accuracy, comprehensiveness, or currency of the content of this work.

This work is no substitute for individual patient assessment based upon healthcare professionals examination of each patient and consideration of, among other things, age, weight, gender, current or prior medical conditions, medication history, laboratory data and other factors unique to the patient. The publisher does not provide medical advice or guidance and this work is merely a reference tool. Healthcare professionals, and not the publisher, are solely responsible for the use of this work including all medical judgments and for any resulting diagnosis and treatments.

Given continuous, rapid advances in medical science and health information, independent professional verification of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options should be made and healthcare professionals should consult a variety of sources. When prescribing medication, healthcare professionals are advised to consult the product information sheet (the manufacturers package insert) accompanying each drug to verify, among other things, conditions of use, warnings and side effects and identify any changes in dosage schedule or contraindications, particularly if the medication to be administered is new, infrequently used or has a narrow therapeutic range. To the maximum extent permitted under applicable law, no responsibility is assumed by the publisher for any injury and/or damage to persons or property, as a matter of products liability, negligence law or otherwise, or from any reference to or use by any person of this work.

LWW.com

Sophia Airhart, MD

Resident
Division of Medical Education

Enrique Alvarez, MD

Fellow
Department of Neurology

Adam Anderson, MD

Fellow
Division of Pulmonary and Critical Care Medicine

Milan J. Anadkat, MD

Associate Professor of Medicine
Division of Dermatology

Ananth Arjunan, MD

Instructor in Medicine
Division of Hospitalist Medicine

Jeffrey J. Atkinson, MD

Assistant Professor of Medicine
Division of Pulmonary and Critical Care Medicine

Sylvia Awadalla, MD

Professor of Neurology
Department of Neurology

Nusayba Bagegni, MD

Instructor in Medicine
Division of Hospitalist Medicine

Maria Q. Baggstrom, MD

Associate Professor of Medicine
Division of Medical Oncology

Ernie-Paul Barrette, MD, FACP

Associate Professor of Medicine
Division of Medical Education

Scott Biest, MD

Associate Professor of Obstetrics and Gynecology
Department of Obstetrics and Gynecology

Melvin Blanchard, MD

Associate Professor of Medicine
Division of Medical Education

Morey A. Blinder, MD

Professor of Medicine
Division of Hematology

Benjamin Bogucki, MD

Fellow
Division of Dermatology

Anthony Boyer, MD

Fellow
Division of Pulmonary and Critical Care Medicine

Richard D. Brasington, MD

Professor of Medicine
Division of Rheumatology

Jared G. Breyley, MD

Resident
Division of Medical Education

Jonathan Byrd, MD

Instructor in Clinical Medicine
Washington University Clinical Associates

Luigi R. Cardella, MD

Instructor in Psychiatry
Department of Psychiatry

David B. Carr, MD

Professor of Medicine
Division of Geriatrics and Nutritional Science

Mario Castro, MD, MPH

Professor of Medicine
Division of Pulmonary and Critical Care Medicine

Murali M. Chakinala, MD

Associate Professor of Medicine
Division of Pulmonary and Critical Care Medicine

Alexander Chen, MD

Assistant Professor of Medicine
Division of Pulmonary and Critical Care Medicine

Steven Cheng, MD

Associate Professor of Medicine
Division of Renal Diseases

Youngjee Choi, MD

Instructor in Medicine
Division of Medical Education

Courtney Chrisler, MD

Instructor in Medicine
Division of Infectious Diseases

Matthew A. Ciorba, MD

Assistant Professor of Medicine
Division of Gastroenterology

Enrique Cornejo Cisneros, MD

Resident
Division of Medical Education

William E. Clutter, MD

Associate Professor of Medicine
Division of Medical Education

Maria C. Dans, MD

Assistant Professor of Medicine
Division of Hospitalist Medicine

Thomas M. De Fer, MD

Professor of Medicine
Division of Medical Education

Shaun C. Desai, MD

Instructor in Otolaryngology
Department of Otolaryngology

Dayna S. Early, MD

Professor of Medicine
Division of Gastroenterology

Charles S. Eby, MD