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Evamarie Hey-Hawkins - Boron-Based Compounds: Potential and Emerging Applications in Medicine

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Noted experts review the current status of boron-containing drugs and materials for molecular medical diagnostics
Boron-Based Compoundsoffers a summary of the present status and promotes the further development of new boron-containing drugs and advanced materials, mostly boron clusters, for molecular medical diagnostics. The knowledge accumulated during the past decades on the chemistry and biology of bioorganic and organometallic boron compounds laid the foundation for the emergence of a new area of study and application of boron compounds as lipophilic pharmacophores and modulators of biologically active molecules.This important text brings together in one comprehensive volume contributions from renowned experts in the field of medicinal chemistry of boron compounds.
The authors cover a range of the most relevant topics including boron compounds as modulators of the bioactivity of biomolecules, boron clusters as pharmacophores or for drug delivery, boron compounds for boron neutron capture therapy (BNCT) and for diagnostics, as well as in silico molecular modeling of boron- and carborane-containing compounds in drug design. Authoritative and accessible,Boron-Based Compounds:
Contains contributions from a panel of internationally renowned experts in the field
Offers a concise summary of the current status of boron-containing drugs and materials used for molecular diagnostics
Highlights the range and capacity of boron-based compounds in medical applications
Includes information on boron neutron capture therapy and diagnostics
Designed for academic and industrial scientists, this important resource offers the cutting-edge information needed to understand the current state of boron-containing drugs and materials for molecular medical diagnostics.

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Table of Contents List of Tables Chapter 11 Chapter 13 Chapter 14 - photo 1
Table of Contents
List of Tables
  1. Chapter 1.1
  2. Chapter 1.3
  3. Chapter 1.4
  4. Chapter 1.5
  5. Chapter 2.3
  6. Chapter 2.4
  7. Chapter 2.5
  8. Chapter 3.2
  9. Chapter 3.5
  10. Chapter 3.6
List of Illustrations
  1. Chapter 1.1
  2. Chapter 1.2
  3. Chapter 1.3
  4. Chapter 1.4
  5. Chapter 1.5
  6. Chapter 1.6
  7. Chapter 2.1
  8. Chapter 2.2
  9. Chapter 2.3
  10. Chapter 2.4
  11. Chapter 2.5
  12. Chapter 3.1
  13. Chapter 3.2
  14. Chapter 3.3
  15. Chapter 3.4
  16. Chapter 3.5
  17. Chapter 3.6
Guide
Pages
BoronBased Compounds

Potential and Emerging Applications in Medicine

Edited by

Evamarie HeyHawkins

Department of Inorganic Chemistry, Leipzig University
Leipzig, Germany

Clara Vias Teixidor

Spanish Council for Scientific Research, Institut de Cincia de Materials de Barcelona
Barcelona, Spain

This edition first published 2018 2018 John Wiley Sons Ltd All rights - photo 2

This edition first published 2018
2018 John Wiley & Sons Ltd

All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions.

The rights of Evamarie HeyHawkins and Clara Vias Teixidor to be identified as the authors of the editorial material in this work has been asserted in accordance with law.

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John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, USA
John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK

Editorial Office
9600 Garsington Road, Oxford, OX4 2DQ, UK

For details of our global editorial offices, customer services, and more information about Wiley products visit us at www.wiley.com.

Wiley also publishes its books in a variety of electronic formats and by printondemand. Some content that appears in standard print versions of this book may not be available in other formats.

Limit of Liability/Disclaimer of Warranty
In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of experimental reagents, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each chemical, piece of equipment, reagent, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. While the publisher and authors have used their best efforts in preparing this work, they make no representations or warranties with respect to the accuracy or completeness of the contents of this work and specifically disclaim all warranties, including without limitation any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives, written sales materials or promotional statements for this work. The fact that an organization, website, or product is referred to in this work as a citation and/or potential source of further information does not mean that the publisher and authors endorse the information or services the organization, website, or product may provide or recommendations it may make. This work is sold with the understanding that the publisher is not engaged in rendering professional services. The advice and strategies contained herein may not be suitable for your situation. You should consult with a specialist where appropriate. Further, readers should be aware that websites listed in this work may have changed or disappeared between when this work was written and when it is read. Neither the publisher nor authors shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages.

Library of Congress CataloginginPublication Data

Names: HeyHawkins, Evamarie, 1957 editor.
Title: Boronbased compounds : potential and emerging applications in medicine / edited by Evamarie HeyHawkins, University of Leipzig, Leipzig, Germany, Clara Vias Teixidor, Institut de Ciencia de Materials de Barcelona, Barcelona, Spain.
Description: First edition. | Hoboken, NJ, USA : Wiley, [2018] | Includes bibliographical references and index. |
Identifiers: LCCN 2017055295 (print) | LCCN 2018009581 (ebook) | ISBN 9781119275589 (pdf) | ISBN 9781119275596 (epub) | ISBN 9781119275558 (cloth)
Subjects: LCSH: Boron compounds. | Boron compoundsDiagnostic use. | Boron compoundsTherapeutic use.
Classification: LCC QD181.B1 (ebook) | LCC QD181.B1 B663 2018 (print) | DDC 615.2/671dc23
LC record available at https://lccn.loc.gov/2017055295

Cover design: Wiley
Cover image: Designer, MSc Christoph Selg

List of Contributors

Anna AdamskaBartomiejczyk
Laboratory of Molecular Virology and Biological Chemistry, IMB PAS, d, Poland

Diego Alberti
Department of Molecular Biotechnology and Health Sciences, University of Torino, Italy

Khaleel I. Assaf
Department of Life Sciences and Chemistry, Jacobs University Bremen, Germany

Hyun Seung Ban
Biomedical Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea

Katarzyna Bednarska
Laboratory of Experimental Immunology, IMB PAS, d, Poland

Magdalena BiaekPietras
Laboratory of Molecular Virology and Biological Chemistry, IMB PAS, d, Poland

Paolo Boggio
Department of Chemistry, University of Torino, Italy

Vladimir I. Bregadze
A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia

Bhaskar C. Das
Departments of Medicine and Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, USA

Sasmita Das
Molecular Bionanotechnology, Imaging and Therapeutic Research Unit, Veteran Affairs Medical Center, Kansas City, USA

Annamaria Deagostino
Department of Chemistry, University of Torino, Italy

Yasuyuki Endo
Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, Japan

Todd Evans
Department of Surgery, Weill Cornell Medical College of Cornell University, New York, USA

Jindich Fanfrlk
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic

Detlef Gabel
Department of Life Sciences and Chemistry, Jacobs University Bremen, Germany

Shanmin Gao
School of Chemistry and Materials Science, Ludong University, China

Marcela A. Garabalino
Department of Radiobiology, National Atomic Energy Commission, San Martn, Buenos Aires Province, Argentina

Simonetta Geninatti Crich
Department of Molecular Biotechnology and Health Sciences, University of Torino, Italy

Vanessa GmezVallejo
Radiochemistry and Nuclear Imaging Group, CIC biomaGUNE, San Sebastian, Spain

Kiran B. Gona
Radiochemistry and Nuclear Imaging Group, CIC biomaGUNE, San Sebastian, Spain Cardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, USA Veterans Affairs Connecticut Healthcare System, West Haven, USA

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