Contents
Guide
FOURTH EDITION
Atlas of Dermatopathology
Synopsis and Atlas of
Levers Histopathology of the Skin
David E. Elder, MB, ChB, FRCPA
Professor of Pathology and Laboratory Medicine
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
Rosalie Elenitsas, MD
Professor of Dermatology
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
Adam I. Rubin, MD
Associate Professor of Dermatology
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
Michael Ioffreda, MD
Associate Professor of Dermatology and Pathology
Penn State Milton S. Hershey Medical Center
Hershey, Pennsylvania
Jeffrey Miller, MD
Professor of Dermatology
Penn State Milton S. Hershey Medical Center
Hershey, Pennsylvania
O. Fred Miller III, MD
Emeritus Director, Department of Dermatology
Geisinger Medical Center
Danville, Pennsylvania
Sook Jung Yun, MD, PhD
Professor of Dermatology
Chonnam National University Medical School
Gwangju, Korea
Acquisitions Editor: Nicole Dernoski
Development Editor: Ariel S. Winter
Editorial Coordinator: Anthony Gonzalez
Editorial Assistant: Maribeth Wood
Marketing Manager: Phyllis Hitner
Production Project Manager: Catherine Ott
Design Coordinator: Joseph Clark
Manufacturing Coordinator: Beth Welsh
Prepress Vendor: Aptara, Inc.
Fourth edition
Copyright 2021 Wolters Kluwer.
Copyright 2013 Lippincott Williams & Wilkins, a Wolters Kluwer Business. Copyright 2007 Lippincott Williams & Wilkins, a Wolters Kluwer business. Copyright 1999 by Lippincott Williams & Wilkins. All rights reserved. This book is protected by copyright. No part of this book may be reproduced or transmitted in any form or by any means, including as photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. To request permission, please contact Wolters Kluwer at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at (products and services).
9 8 7 6 5 4 3 2 1
Printed in China
Library of Congress Cataloging-in-Publication Data
Names: Elder, David E., author.
Title: Atlas of dermatopathology : synopsis and atlas of Levers histopathology of the skin / David E. Elder, Rosalie Elenitsas, Adam I. Rubin, Michael Ioffreda, Jeffrey Miller, O. Fred Miller III, Sook Jung Yun.
Description: Fourth edition. | Philadelphia : Wolters Kluwer, 2021. | Preceded by Atlas and synopsis of Levers histopathology of the skin / David E. Elder [et al.]. 3rd ed. c2013. | Includes bibliographical references and index. | Summary: In this new edition, as in its predecessors, we have extensively updated the text, based on review of the recent literature, and also on material from the latest (11th) edition of Levers Histopathology of the Skin. We have added more extensive discussion of several diseases that were either not covered or only briefly mentioned with little or no elaboration in the earlier editions, and have added current references to the literature. We have added multiple new images including clinical images of conditions that were not formerly illustrated. These are original digital images of high quality. As in the last edition, the histopathologic images have been prepared from digital slides and the quality is state of the art, especially noticeable in the low-power images. These images are to be provided online for the readers convenience. We have continued the use of arrows and labels on the photomicrographs, adapted from the style used in Sara Edwards excellent book Essential Dermatopathology. In addition, we have continued the practice of using tables to summarize the most salient diagnostic features of potential look-alike diseases Provided by publisher.
Identifiers: LCCN 2020000391 | ISBN 9781975124632 (paperback) | ISBN 9781975124656 (epub)
Subjects: MESH: Skin Diseasespathology | Skin Diseasesdiagnosis | Skinpathology | Atlas
Classification: LCC RL71 | NLM WR 17 | DDC 616.5dc23
LC record available at https://lccn.loc.gov/2020000391
This work is provided as is, and the publisher disclaims any and all warranties, express or implied, including any warranties as to accuracy, comprehensiveness, or currency of the content of this work.
This work is no substitute for individual patient assessment based upon healthcare professionals examination of each patient and consideration of, among other things, age, weight, gender, current or prior medical conditions, medication history, laboratory data and other factors unique to the patient. The publisher does not provide medical advice or guidance and this work is merely a reference tool. Healthcare professionals, and not the publisher, are solely responsible for the use of this work including all medical judgments and for any resulting diagnosis and treatments.
Given continuous, rapid advances in medical science and health information, independent professional verification of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options should be made and healthcare professionals should consult a variety of sources. When prescribing medication, healthcare professionals are advised to consult the product information sheet (the manufacturers package insert) accompanying each drug to verify, among other things, conditions of use, warnings and side effects and identify any changes in dosage schedule or contraindications, particularly if the medication to be administered is new, infrequently used or has a narrow therapeutic range. To the maximum extent permitted under applicable law, no responsibility is assumed by the publisher for any injury and/or damage to persons or property, as a matter of products liability, negligence law or otherwise, or from any reference to or use by any person of this work.
shop.lww.com
BRIEF CONTENTS
HOW TO USE THIS BOOK
In this book, diseases are classified not by the usual pathophysiologic classification but according to a pattern classification, more fully discussed in the Introduction on page xxiii.
In this pattern classification, the diseases are classified first as to their location in the skin, then according to morphologic patterns that may present in those particular locations, and then according to the cell types involved. Generally speaking, these classifiers can be thought of as low-power, medium-power, and high-power microscopic features.
There are eight specified locations, which are assigned Roman numerals I through VIII, as follows below.
- Disorders Mostly Limited to the Epidermis and Stratum Corneum
- Localized Superficial Epidermal or Melanocytic Proliferations
- Disorders of the Superficial Cutaneous Reactive Unit
- Acantholytic, Vesicular, and Pustular Disorders
- Perivascular, Diffuse, and Granulomatous Infiltrates of the Reticular Dermis