David E. Elder et al. (eds.) - Lever’s Histopathology of the Skin

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Levers Histopathology of the Skin

ELEVENTH EDITION

Levers Histopathology of the Skin

Editor-in-Chief

David E. Elder, MB, CHB, FRCPA

Professor of Pathology and Laboratory Medicine

Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania

Associate Editors

Rosalie Elenitsas, MD

Professor of Dermatology

Director of Dermatopathology

Department of Dermatology

Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania

Misha Rosenbach, MD

Assistant Professor of Dermatology & Internal Medicine

Associate Program Director, Dermatology Residency

Director, Dermatology Inpatient Consult Service

Director, Cutaneous Sarcoidosis Clinic

Perelman School of Medicine

University of Pennsylvania

Philadelphia, Pennsylvania

George F. Murphy, MD

Professor of Pathology

Harvard Medical School

Director, Program in Dermatopathology

Department of Pathology

Brigham and Womens Hospital

Boston, Massachusetts

Adam I. Rubin, MD

Assistant Professor of Dermatology

Hospital of the University of Pennsylvania

The Childrens Hospital of Philadelphia

Perelman School of Medicine

University of Pennsylvania

Philadelphia, Pennsylvania

Xiaowei Xu, MD, PhD

Associate Professor

Department of Pathology and Laboratory Medicine

University of Pennsylvania

Philadelphia, Pennsylvania

Acquisitions Editor: Ryan Shaw

Product Development Manager: Kate Marshall

Production Project Manager: Alicia Jackson

Senior Manufacturing Coordinator: Beth Welsh

Marketing Manager: Dan Dressler

Designer: Holly McLaughlin

Production Service: S4Carlisle Publishing Services

Two Commerce Square

2001 Market Street

Philadelphia, PA 19103 USA

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11th edition

Copyright 2015 Wolters Kluwer

Tenth Edition, 2009 by Lippincott Williams & Wilkins, a Wolters Kluwer business, Ninth Edition, 2004 by Lippincott Williams & Wilkins, Eighth Edition, 1997 by Lippincott Williams & Wilkins, Seventh Edition, 1990 by JB Lippincott, Sixth Edition, 1983 by JB Lippincott, Fifth Edition, 1975 by JB Lippincott

All rights reserved. This book is protected by copyright. No part of this book may be reproduced or transmitted in any form or by any means, including as photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. To request permission, please contact Wolters Kluwer Health at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at , or via our website at lww.com (products and services).

9 8 7 6 5 4 3 2 1

Printed in China

Library of Congress Cataloging-in-Publication Data

Levers histopathology of the skin / editor in chief, David E. Elder ; associate editors, Rosalie Elenitsas, Misha Rosenbach, George F. Murphy, Adam I. Rubin, Xiaowei Xu. Eleventh edition.

p. ; cm.

Histopathology of the skin

Includes bibliographical references and index.

ISBN 978-1-4511-9037-3 (hardback : alk. paper)

I. Elder, David E., editor. II. Title: Histopathology of the skin.

[DNLM: 1. Skin Diseasespathology. WR 105]

RL95

616.5'07dc23

2014028965

This work is provided as is, and the publisher disclaims any and all warranties, express or implied, including any warranties as to accuracy, comprehensiveness, or currency of the content of this work.

This work is no substitute for individual patient assessment based upon healthcare professionals examination of each patient and consideration of, among other things, age, weight, gender, current or prior medical conditions, medication history, laboratory data, and other factors unique to the patient. The publisher does not provide medical advice or guidance and this work is merely a reference tool. Healthcare professionals, and not the publisher, are solely responsible for the use of this work including all medical judgments and for any resulting diagnosis and treatments.

Given continuous, rapid advances in medical science and health information, independent professional verification of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options should be made and healthcare professionals should consult a variety of sources. When prescribing medication, healthcare professionals are advised to consult the product information sheet (the manufacturers package insert) accompanying each drug to verify, among other things, conditions of use, warnings and side effects and identify any changes in dosage schedule or contradictions, particularly if the medication to be administered is new, infrequently used or has a narrow therapeutic range. To the maximum extent permitted under applicable law, no responsibility is assumed by the publisher for any injury and/or damage to persons or property, as a matter of products liability, negligence law or otherwise, or from any reference to or use by any person of this work.

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Dedication

This Edition is dedicated to our families who have supported us in our endeavors leading up to this work, and to our teachers and mentors in medicine and surgery, pathology and dermatopathology, too numerous to name individually, whose commitment to the discovery and dissemination of knowledge, and patient tutoring at the bedside, bench and microscope, enabled this work to be accomplished.

Contributors

Khadija Aljefri, MBChB, MSc, MRCP(UK)

Department of Dermatology

Royal Victoria Infirmary

Newcastle upon Tyne

United Kingdom

Anne E. Allan, MD

Dermatopathologist

StrataDX

Lexington, Massachusetts

Lisa Arkin, MD

Pediatric Dermatology Fellow

Section of Pediatric Dermatology

University of Pennsylvania

Philadelphia, Pennsylvania

Johanna L. Baran, MD

Pathologist/Dermatopathologist

Western Dermatopathology Services

San Luis Obispo, California

Sarah K. Barksdale, MD

Dermatopathologist

Sullivan Nicolaides Pathology

Brisbane, Australia

Raymond L. Barnhill, MD, MSc

Professor

Dpartement de Biopathologie

Institut Curie

Paris, France

Adjunct Professor

Department of Pathology and Laboratory Medicine

David Geffen School of Medicine

University of California, Los Angeles

Los Angeles, California

Trevor W. Beer, MBChB, FRCPath, FRCPA

Dermatopathologist

Clinipath Pathology

Osborne Park, Western Australia, Australia

Thomas Brenn, MD, PhD, FRCPath

Lead Consultant Dermatopathologist

Department of Pathology

Western General Hospital

The University of Edinburgh