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David A. Williams PhD - Essentials of Foye’s Principles of Medicinal Chemistry

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David A. Williams PhD Essentials of Foye’s Principles of Medicinal Chemistry
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Essentials of Foye’s Principles of Medicinal Chemistry: summary, description and annotation

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Written in response to reader requests for a short, to the point text that clearly summarizes the most important chemical elements of therapeutically relevant drug classes, Essentials of Foyes Principles of Medicinal Chemistry is a concise, quick-reference source of reliable information in the field. Derived from the highly regarded Foyes Principles of Medicinal Chemistry, this focused text provides an essential understanding of drug action and demonstrates its practical application to todays pharmacy practice.
  • Highlights the take home chemical points of every chapter in the parent text, and uses an easy-to-read, bulleted format to convey essential concepts.
  • Covers mechanism of action (MOA), structure-activity relationships (SAR), physicochemical and pharmacokinetic properties, metabolism, and clinical applications in all chapters.
  • Uses numerous figures and tables to illustrate key concepts and make reference quick and easy.
  • Summarizes additional information such as adverse effects, drug-drug or drug-food interactions, chemical points of interest, and unique aspects of clinical use in side boxes or Chemical Note side bars.
  • Concludes each chapter with a section emphasizing the clinical relevance of chapter content, as well as review questions for self-assessment.
  • Written by the same international team of renowned researchers and academicians as Foyes Principles of Medicinal Chemistry
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Essentials of Foyes Principles of Medicinal Chemistry Thomas L Lemke PhD - photo 1
Essentials of Foyes Principles of Medicinal Chemistry
Thomas L. Lemke, PhD

Professor Emeritus

College of Pharmacy

University of Houston

Houston, Texas

S. William Zito, PhD

Professor of Pharmaceutical Sciences

College of Pharmacy and Allied Health Professions

St. Johns University

Jamaica, New York

Victoria F. Roche, PhD

Professor of Pharmacy Sciences

School of Pharmacy and Health Professions

Creighton University

Omaha, Nebraska

David A. Williams, PhD

Professor Emeritus of Chemistry

School of Pharmacy

MCPHS University

Boston, Massachusetts

Acquisitions Editor Matt Hauber Senior Product Development Editor Amy - photo 2

Acquisitions Editor: Matt Hauber

Senior Product Development Editor: Amy Millholen

Editorial Assistant: Brooks Phelps

Marketing Manager: Michael McMahon

Production Project Manager: Marian Bellus

Design Coordinator: Joan Wendt

Manufacturing Coordinator: Margie Orzech

Prepress Vendor: Aptara, Inc.

Copyright 2017 Wolters Kluwer

All rights reserved. This book is protected by copyright. No part of this book may be reproduced or transmitted in any form or by any means, including as photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. To request permission, please contact Wolters Kluwer at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at (products and services).

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Printed in China

Library of Congress Cataloging-in-Publication Data

Names: Lemke, Thomas L., author. | Zito, S. William, author. | Roche,

Victoria F., author. | Williams, David A., author.

Title: Essentials of Foyes principles of medicinal chemistry / Thomas L.

Lemke, S. William Zito, Victoria F. Roche, David A. Williams.

Description: Philadelphia : Wolters Kluwer, [2017] | Includes index. |

Abridgement of: Foyes principles of medicinal chemistry / edited by

Thomas L. Lemke, David A. Williams ; associate editors, Victoria F. Roche,

S. William Zito. 7th ed. c2003.

Identifiers: LCCN 2016000560 | ISBN 9781451192063

Subjects: | MESH: Chemistry, Pharmaceutical

Classification: LCC RS403 | NLM QV 744 | DDC 616.07/56dc23

LC record available at http://lccn.loc.gov/2016000560

This work is provided as is, and the publisher disclaims any and all warranties, express or implied, including any warranties as to accuracy, comprehensiveness, or currency of the content of this work.

This work is no substitute for individual patient assessment based upon healthcare professionals examination of each patient and consideration of, among other things, age, weight, gender, current or prior medical conditions, medication history, laboratory data and other factors unique to the patient. The publisher does not provide medical advice or guidance and this work is merely a reference tool. Healthcare professionals, and not the publisher, are solely responsible for the use of this work including all medical judgments and for any resulting diagnosis and treatments.

Given continuous, rapid advances in medical science and health information, independent professional verification of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options should be made and healthcare professionals should consult a variety of sources. When prescribing medication, healthcare professionals are advised to consult the product information sheet (the manufacturers package insert) accompanying each drug to verify, among other things, conditions of use, warnings and side effects and identify any changes in dosage schedule or contraindications, particularly if the medication to be administered is new, infrequently used or has a narrow therapeutic range. To the maximum extent permitted under applicable law, no responsibility is assumed by the publisher for any injury and/or damage to persons or property, as a matter of products liability, negligence law or otherwise, or from any reference to or use by any person of this work.

LWW.com

Dedication to William O. Foye

William O. Foye, Sawyer Professor of Medicinal Chemistry at the MCPHS University (formerly Massachusetts College of Pharmacy), Boston, MA, was born in 1923 in western Massachusetts. He received his BA (1944) in chemistry from Dartmouth College and PhD in Organic Chemistry (M. Carmack) from Indiana University in 1948. He served in the U.S. Navy during World War II as a chemical warfare instructor. He joined DuPont (Delaware) as a research scientist, then in 1950 joined the School of Pharmacy at the University of Wisconsin as assistant professor of pharmaceutical chemistry. In 1955, he moved to MCPHS University, Boston as Professor of Chemistry, where he brought a new vision of pharmaceutical chemistry (medicinal chemistry) to the pharmacy curriculum. As department chair, he advocated for organic medicinal chemistry in the pharmacy curriculum.

The impetus for a new text in medicinal chemistry, grounded on Alfred Burgers two-volume Medicinal Chemistry, came from Dr. Norman Doorenbos, College of Pharmacy University of Maryland (Baltimore), who had made arrangements with Lea & Febiger (forerunner of Lippincott Williams and Wilkins) for publishing a companion text to Wilson & Gisvolds Textbook of Organic Medicinal and Pharmaceutical Chemistry. Because Dr. Doorenbos was moving to chair the new Pharmacognosy Department at the School of Pharmacy, University of Mississippi, he relinquished the job of editing this text to Dr. Foye. During this time, a number of teachers and researchers in medicinal chemistry felt that a text on drugs that included biochemical modes of action, aimed primarily for undergraduates, should be written. Although other pharmaceutical and medicinal chemistry books had been written during this time (The Chemistry of Organic Medicinal Products, Jenkins and Hartung, and Textbook of Organic Medicinal and Pharmaceutical Chemistry, Wilson and Gisvold), these authors organized their books according to the accepted scheme of chemical classification of the more important organic medicinal compounds, their methods of synthesis, properties and descriptions, and their uses and modes of administration. Therefore, this Principles text provided a contemporary basis for the biochemical understanding of drug action that included the principles of structure function relationships and drug metabolism. Dr. Foye assembled authors who were experts in their respective fields and published the first edition of Principles of Medicinal Chemistry in 1972.

The current authors of the 7th edition Foyes Principles of Medicinal Chemistry uphold the original concept for an undergraduate medicinal chemistry principles textbook to assist its readers to pull together the chemical understanding of drug action and to appreciate its practical relevance to contemporary pharmacy practice. Because medicinal chemistry students have often expressed the desire for a short and to the point text that clearly summarizes the most important chemical elements of therapeutically relevant drug classes, the

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