Essentials of Foyes Principles of Medicinal Chemistry
Thomas L. Lemke, PhD
Professor Emeritus
College of Pharmacy
University of Houston
Houston, Texas
S. William Zito, PhD
Professor of Pharmaceutical Sciences
College of Pharmacy and Allied Health Professions
St. Johns University
Jamaica, New York
Victoria F. Roche, PhD
Professor of Pharmacy Sciences
School of Pharmacy and Health Professions
Creighton University
Omaha, Nebraska
David A. Williams, PhD
Professor Emeritus of Chemistry
School of Pharmacy
MCPHS University
Boston, Massachusetts
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Library of Congress Cataloging-in-Publication Data
Names: Lemke, Thomas L., author. | Zito, S. William, author. | Roche,
Victoria F., author. | Williams, David A., author.
Title: Essentials of Foyes principles of medicinal chemistry / Thomas L.
Lemke, S. William Zito, Victoria F. Roche, David A. Williams.
Description: Philadelphia : Wolters Kluwer, [2017] | Includes index. |
Abridgement of: Foyes principles of medicinal chemistry / edited by
Thomas L. Lemke, David A. Williams ; associate editors, Victoria F. Roche,
S. William Zito. 7th ed. c2003.
Identifiers: LCCN 2016000560 | ISBN 9781451192063
Subjects: | MESH: Chemistry, Pharmaceutical
Classification: LCC RS403 | NLM QV 744 | DDC 616.07/56dc23
LC record available at http://lccn.loc.gov/2016000560
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Dedication to William O. Foye
William O. Foye, Sawyer Professor of Medicinal Chemistry at the MCPHS University (formerly Massachusetts College of Pharmacy), Boston, MA, was born in 1923 in western Massachusetts. He received his BA (1944) in chemistry from Dartmouth College and PhD in Organic Chemistry (M. Carmack) from Indiana University in 1948. He served in the U.S. Navy during World War II as a chemical warfare instructor. He joined DuPont (Delaware) as a research scientist, then in 1950 joined the School of Pharmacy at the University of Wisconsin as assistant professor of pharmaceutical chemistry. In 1955, he moved to MCPHS University, Boston as Professor of Chemistry, where he brought a new vision of pharmaceutical chemistry (medicinal chemistry) to the pharmacy curriculum. As department chair, he advocated for organic medicinal chemistry in the pharmacy curriculum.
The impetus for a new text in medicinal chemistry, grounded on Alfred Burgers two-volume Medicinal Chemistry, came from Dr. Norman Doorenbos, College of Pharmacy University of Maryland (Baltimore), who had made arrangements with Lea & Febiger (forerunner of Lippincott Williams and Wilkins) for publishing a companion text to Wilson & Gisvolds Textbook of Organic Medicinal and Pharmaceutical Chemistry. Because Dr. Doorenbos was moving to chair the new Pharmacognosy Department at the School of Pharmacy, University of Mississippi, he relinquished the job of editing this text to Dr. Foye. During this time, a number of teachers and researchers in medicinal chemistry felt that a text on drugs that included biochemical modes of action, aimed primarily for undergraduates, should be written. Although other pharmaceutical and medicinal chemistry books had been written during this time (The Chemistry of Organic Medicinal Products, Jenkins and Hartung, and Textbook of Organic Medicinal and Pharmaceutical Chemistry, Wilson and Gisvold), these authors organized their books according to the accepted scheme of chemical classification of the more important organic medicinal compounds, their methods of synthesis, properties and descriptions, and their uses and modes of administration. Therefore, this Principles text provided a contemporary basis for the biochemical understanding of drug action that included the principles of structure function relationships and drug metabolism. Dr. Foye assembled authors who were experts in their respective fields and published the first edition of Principles of Medicinal Chemistry in 1972.
The current authors of the 7th edition Foyes Principles of Medicinal Chemistry uphold the original concept for an undergraduate medicinal chemistry principles textbook to assist its readers to pull together the chemical understanding of drug action and to appreciate its practical relevance to contemporary pharmacy practice. Because medicinal chemistry students have often expressed the desire for a short and to the point text that clearly summarizes the most important chemical elements of therapeutically relevant drug classes, the