James D. Watson - DNA: The Secret of Life

DNA: The Secret of Life was conceived over dinner in 1999. Under discussion was how best to mark the fiftieth anniversary of the discovery the double helix. Publisher Neil Patterson joined one of us, James D. Watson, in dreaming up a multifaceted venture including this book, a television series, and additional more avowedly educational projects. Neil's presence was no accident: he published JDW's first book, The Molecular Biology of the Gene, in 1965, and ever since has lurked genielike behind JDW's writing projects. Doron Weber at the Alfred P. Sloan Foundation then secured seed money to ensure that the idea would turn into something more concrete. Andrew Berry was recruited in 2000 to hammer out a detailed outline for the TV series and has since become a regular commuter between his base in Cambridge, Massachusetts, and JDW's at Cold Spring Harbor Laboratory on the north coast of Long Island, close to New York City.

From the start, our goal was to go beyond merely recounting the events of the past fifty years. DNA has moved from being an esoteric molecule only of interest to a handful of specialists to being the heart of a technology that is transforming many aspects of the way we all live. With that transformation has come a host of difficult questions about its impact practical, social, and ethical. Taking the fiftieth anniversary as an opportunity to pause and take stock of where we are, we give an unabashedly personal view both of the history and of the issues. Moreover, it is JDW's personal view and is accordingly written in the first-person singular. The double helix was already ten years old when DNA was working its in utero magic on a fetal AB.

We have tried to write for a general audience, intending that someone with zero biological knowledge should be able to understand the book's every word. Every technical term is explained when first introduced. Should you need to refresh your memory about a term when you come across one of its later appearances, you can refer to the index, where such words are printed in bold to make locating them easy; a number also in bold will take you to the page on which the term is defined. We have inevitably skimped on many of the technical details and recommend that readers interested in learning more go to DNAi.org, the Web site of the multimedia companion project, DNA Interactive, aimed at high-schoolers and entry-level college students. Here you will find animations explaining basic processes and an extensive archive of interviews with the scientists involved. In addition, the Further Reading section lists books relevant to each chapter. Where possible we have avoided the technical literature, but the titles listed nevertheless provide a more in-depth exploration of particular topics than we supply.

We thank the many people who contributed generously to this project in one way or another in the acknowledgments at the back of the book. Four individuals, however, deserve special mention. George Andreou, our preternaturally patient editor at Knopf, wrote much more of this book the good bits than either of us would ever let on. Kiryn Haslinger, our superbly efficient assistant at Cold Spring Harbor Lab, cajoled, bullied, edited, researched, nit-picked, mediated, wrote all in approximately equal measure. The book simply would not have happened without her. Jan Witkowski, also of Cold Spring Harbor Lab, did a marvelous job of pulling together chapters 10, 11, and 12 in record time and provided indispensable guidance throughout the project. Maureen Berejka, JDW's assistant, rendered sterling service as usual in her capacity as the sole inhabitant of Planet Earth capable of interpreting JDW's handwriting.

James D. Watson

Cold Spring Harbor, New York

Andrew Berry

Cambridge, Massachusetts