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Kenneth S. Korach - Reproductive and developmental toxicology

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This timely resource offers extensive discussions on the pharmacological, environmental,endocrinological, and natural factors that alter reproductive or developmental processes-elucidating the effects of toxicants on mechanisms of reproduction. Describing biological actions common to both genders as well as gender-specific processes, Reproductive and Developmental Toxicology provides an overview of the basic biology and physiology of organ systems affected by toxicants furnishes detailed examples of developmental toxicology analyzes germ cell toxicity and infertility covers the developmental effects of neurotoxicity considers periods of exposure and long-term toxicological consequences explains how gonadal processes may be susceptible to toxicants in other reproductive organ systems and more! With over 3700 bibliographic citations and more than 100 photographs, drawings, and tables, Reproductive and Developmental Toxicology is a useful reference for toxicologists; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; obstetricians/gynecologists; pediatricians; pharmacists and pharmacologists; physiologists; geneticists; poison control specialists; and upper-level undergraduate, graduate, and medical school students in these disciplines.

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title Reproductive and Developmental Toxicology author Korach - photo 1

title:Reproductive and Developmental Toxicology
author:Korach, Kenneth S.
publisher:CRC Press
isbn10 | asin:0824798570
print isbn13:9780824798574
ebook isbn13:9780585158075
language:English
subjectReproductive toxicology, Developmental toxicology.
publication date:1998
lcc:RA1224.2.R46 1998eb
ddc:615.9
subject:Reproductive toxicology, Developmental toxicology.
Page i
Reproductive and Developmental Toxicology
Edited by
Kenneth S.
Korach
National Institute of Environmental Health Sciences
Research Triangle Park, North Carolina
Reproductive and developmental toxicology - image 2
MARCEL DEKKER, INC.
NEW YORK BASEL HONG KONG
Page ii
Library of Congress Cataloging-in-Publication Data
Reproductive and developmental toxicology/edited by Kenneth S. Korach.
p. cm.
Includes bibliographical references and index.
ISBN 0-8247-9857-0 (alk. paper)
1. Reproductive toxicology. 2. Developmental toxicology.
I. Korach, Kenneth S.
RA1224.2.R46 1998 98-5182
615.9--dc21 CIP
The publisher offers discounts on this book when ordered in bulk quantities. For more information, write to Special Sales/Professional Marketing at the address below.
This book is printed on acid-free paper.
Copyright 1998 by MARCEL DEKKER, INC. All Rights Reserved.
Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage and retrieval system, without permission in writing from the publisher.
MARCEL DEKKER, INC.
270 Madison Avenue, New York, New York 10016
http://www.dekker.com
Current printing (last digit):
10 9 8 7 6 5 4 3 2 1
PRINTED IN THE UNITED STATES OF AMERICA
Page iii
FOREWORD
Thanks to the insight of the editor and the scholarly contributions of the authors, this book captures in one volume the essence of the threshold of science that is currently being experienced in the areas of biology and toxicology. It is not very often in science and medicine that scientific breakthroughs occur at a time when the public and the community of scientists and clinicians are primed to accept them and use them to move the field forward. A scientific breakthrough may not cause much of a stir if it happens at a time when there is no critical context in which to place the finding. On the other hand, a human health or environmental catastrophe may present a critical context for good science, but if new scientific understanding is not forthcoming, the incident passes without a step forward in science. When thalidomide and 1,2-dibromo-3-chloropropane (DBCP) produced chemical-induced human malformations and infertility, respectively, in neither case did we learn much about the biology of development or reproduction beyond the establishment of causality. Science was not prepared to capitalize on these situations when the tragedies occurred. Thus, the exposure was stopped and further damage was prevented, but the knowledge gained was chemical-specific and did not have broad application in toxicology or medicine.
The compilation of data in this book represents integration of a new level of biological understanding into the fields of reproductive and developmental toxicology. This new influx of mechanistic understanding comes at a time when extrapolation of animal data to humans has reached a scientific plateau. Importantly, these scientific advancements that represent threshold referred to earlier have occurred at a time when the public and scientific communities have been sensitized to the importance of this area by questions about endocrine disrupters in the environment. Scientists are poised today to evaluate the significance of new findings through the use of research tools that were unavailable during the crises with thalidomide and DBCP. Thus, the question of whether exposure to low levels of hormonally active substances in the environment poses a threat to human health has surfaced at a time when new laboratory tools, such as transgenic animals and molecular techniques to better understand the underlying basis for toxicological findings, can be used to provide mechanism-based information to support decisions for protection of human and environmental health.
All three sections of this book successfully demonstrate the interface between new biological understanding and its application to toxicological problems. The authors of individual chapters are leaders in their respective disciplines. The findings they present are an objective view of the leading edge of science in the areas of development and
Page iv
male and female reproduction. Perhaps more importantly, their research approaches and the underlying biological concepts help to form the future basis for identifying potential toxicological hazards and for enhancing risk assessment procedures in the areas of reproductive and developmental toxicology.
Picture 3
BERNARD A. SCHWETZ
DIRECTOR, NATIONAL CENTER FOR
TOXICOLOGICAL RESEARCH
JEFFERSON, ARKANSAS, AND
INTERIM CHIEF SCIENTIST OF THE FDA
ROCKVILLE, MARYLAND
Page v
PREFACE
Reproduction and reproductive sciences encompass an area that spans a number of scientific disciplines, including endocrinology, cell biology, physiology, anatomy, developmental biology, biochemistry, and molecular biology. Because the reproductive process is critical for perpetuation of any species of organisms, factors or agents that alter or disrupt this process can have devastating consequences.
We now realize that such agents can arise from varying sourceswhich can be pharmacological, environmental, and naturalhaving extensive chemical structural diversity. In addition, the effects can be through a single action, or in combination, and can influence either individual or multiple cellular signaling pathways in a tissue or organ system. As such, it is difficult to ascribe a single action or effect to certain agents. This is why studies, such as those described in this volume, which incorporate the latest scientific approaches and findings, provide the scientific basis from experimental studies to determine the extent, magnitude, and severity of exposure to certain compounds. Such experimental observations will have direct relevance toward human exposure and its resultant consequences for fertility and normal development.
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