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Watkins John Barr - Casarett & Doulls Essentials of Toxicology

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General principles of toxicology. History and scope of toxicology / Michael A. Gallo ; Principles of toxicology / David L. Eaton and Steven G. Gilbert ; Mechanisms of toxicity / Zoltn Gregus ; Risk assessment / Elaine M. Faustman and Gilbert S. Omenn -- Disposition of toxicants. Absorption, distribution, and excretion of toxicants / Lois D. Lehman-McKeeman ; Biotransformation of xenobiotics / Andrew Parkinson and Brian W. Ogilvie ; Toxicokinetics / Danny D. Shen -- Nonorgan-directed toxicity. Chemical carcinogenesis / James E. Klaunig and Lisa M. Kamendulis ; Genetic toxicology / R. Julian Preston and George R. Hoffmann ; Developmental toxicoogy / John M. Rogers and Robert J. Kavlock.;Target organ toxicity. Toxic responses of the blood / John C. Bloom and John T. Brandt ; Toxic responses of the immune system / Norbert E. Kaminski, Barbara L. Faubert Kaplan, and Michael P. Holsapple ; Toxic responses of the liver / Hartmut Jaeschke ; Toxic responses of the kidney / Rick G. Schnellmann ; Toxic responses of the respiratory system / Hanspeter R. Witschi [and others] ; Toxic responses of the nervous system / Virginia C. Moser [and others] ; Toxic responses of the ocular and visual system / Donald A. Fox and William K. Boyes ; Toxic responses of the heart and vascular system / Y. James Kang ; Toxic resposes of the skin / Robert H. Rice and Theodora M. Mauro ; Toxic responses of the reproductive system / Paul M.D. Foster and L. Earl Gray, Jr. ; Toxic responses of the endocrine system / Charles C. Capen.;Toxic agents. Toxic effects of pesticides / Lucio G. Costa ; Toxic effects of metals / Jie Liu, Robert A. Goyer, and Michael P. Waalkes ; Toxic effects of solvents and vapors / James V. Bruckner, S. Satheesh Anand and D. Alan Warren ; Toxic effects of radiation and radioactive materials / Naomi H. Harley ; Toxic effects of terrestrial animal venoms and poisons / John B. Watkins III ; Toxic effects of plants, fungi, and algae / Stata Norton -- Environmental toxicology. Air pollution / Daniel L. Costa ; Ecotoxicology / Richard T. Di Giulio and Michael C. Newman -- Applications of toxicology. Food toxicology / Frank N. Kotsonis and George A. Burdock ; Analytic/forensic toxicology / Alphonse Poklis ; Clinical toxicology / Louis R. Cantilena, Jr. ; Occupational toxicology / Peter S. Thorne.;We are delighted to present an updated full color, edition of Essentials of Toxicology, which distills the major principles and concepts of toxicology that were described in detail in the seventh edition of Casarett and Doulls Toxicology: The Basic Science of Poisons. We are grateful to the colleagues who contributed to the seventh edition of Casarett and Doulls Toxicology: The Basic Science of Poisons; their contributions to the parent text served as the foundation for the chapters in this edition of Essentials of Toxicology. Essentials of Toxicology concisely presents the broad science of toxicology. Important concepts from anatomy, physiology and biochemistry have been included to facilitate the understanding of the principles and mechanisms of toxicant action on specific organ systems. It is hoped that the book will be useful to students in undergraduate and graduate courses in toxicology, as well as students from other disciplines, who want to have a strong foundation in toxicologic concepts and principles--Provided by publisher.

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Casarett & Doulls Essentials of Toxicology


NOTICE

Medicine is an ever-changing science. As new research and clinical experience broaden our knowledge, changes in treatment and drug therapy are required. The authors and the publisher of this work have checked with sources believed to be reliable in their efforts to provide information that is complete and generally in accord with the standards accepted at the time of publication. However, in view of the possibility of human error or changes in medical sciences, neither the authors nor the publisher nor any other party who has been involved in the preparation or publication of this work warrants that the information contained herein is in every respect accurate or complete, and they disclaim all responsibility for any errors or omissions or for the results obtained from use of the information contained in this work. Readers are encouraged to confirm the information contained herein with other sources. For example and in particular, readers are advised to check the product information sheet included in the package of each drug they plan to administer to be certain that the information contained in this work is accurate and that changes have not been made in the recommended dose or in the contraindications for administration. This recommendation is of particular importance in connection with new or infrequently used drugs.


Casarett & Doulls Essentials of Toxicology

Second Edition

Editors

Curtis D. Klaassen, PhD

University Distinguished Professor and Chair
Department of Pharmacology, Toxicology, and Therapeutics
University of Kansas Medical Center
Kansas City, Kansas

John B. Watkins III, PhD

Assistant Dean and Director
Professor of Pharmacology and Toxicology
Medical Sciences Program
Indiana University School of Medicine
Bloomington, Indiana

Copyright 2010 by The McGraw-Hill Companies Inc All rights reserved Except - photo 1

Copyright 2010 by The McGraw-Hill Companies Inc All rights reserved Except - photo 2

Copyright 2010 by The McGraw-Hill Companies, Inc. All rights reserved. Except as permitted under the United States Copyright Act of 1976, no part of this publication may be reproduced or distributed in any form or by any means, or stored in a database or retrieval system, without the prior written permission of the publisher.

ISBN: 978-0-07-176651-7

MHID: 0-07-176651-0

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Contents

Michael A. Gallo

David L. Eaton and Steven G. Gilbert

Zoltn Gregus

Elaine M. Faustman and Gilbert S. Omenn

Lois D. Lehman-McKeeman

Andrew Parkinson and Brian W. Ogilvie

Danny D. Shen

James E. Klaunig and Lisa M. Kamendulis

R. Julian Preston and George R. Hoffmann

John M. Rogers and Robert J. Kavlock

John C. Bloom and John T. Brandt

Norbert E. Kaminski, Barbara L. Faubert Kaplan, and Michael P. Holsapple

Hartmut Jaeschke

Rick G. Schnellmann

Hanspeter R. Witschi, Kent E. Pinkerton, Laura S. Van Winkle, and Jerold A. Last

Virginia C. Moser, Michael Aschner, Rudy J. Richardson, and Martin A. Philbert

Donald A. Fox and William K. Boyes

Y. James Kang

Robert H. Rice and Theodora M. Mauro

Paul M. D. Foster and L. Earl Gray Jr.

Charles C. Capen

Lucio G. Costa

Jie Liu, Robert A. Goyer, and Michael P. Waalkes

James V. Bruckner, S. Satheesh Anand and D. Alan Warren

Naomi H. Harley

John B. Watkins III

Stata Norton

Daniel L. Costa

Richard T. Di Giulio and Michael C. Newman

Frank N. Kotsonis and George A. Burdock

Alphonse Poklis

Louis R. Cantilena Jr.

Peter S. Thorne

Contributors

Michael Aschner, PhD

Gray E.B. Stahlman Chair in Neuroscience,
Professor of Pediatrics and Pharmacology and
Senior Investigator of the Kennedy Center,
Vanderbilt University, Nashville, Tennessee

S. Satheesh Anand, PhD

Research Toxicologist, DuPont Haskell Laboratory for
Health and Environmental Sciences, Newark, Delaware

John C. Bloom, VMD, PhD

Executive Director, Distinguished Medical Fellow,
Diagnostic and Experimental Medicine,
Eli Lilly and Company, Indianapolis, Indiana

William K. Boyes, PhD

Neurotoxicology Division
National Health and Environmental Effects Research
Laboratory, Office of Research and Development,

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