A Wallace Hayes - Principles and Methods of Toxicology

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Principles and Methods of Toxicology 4Th Ed.

Taylor & Francis RoutledgeHayes, A. Wallace0203362837

9780203379639

9780203362839

Toxicology, Toxicology--methods, Poisoning, Poisons,EnglishToxicity Tests, Toxicologa, Toxicologie , Toxicit

2001

RA1211.P74 2001eb

615.9

Toxicity Tests, Toxicologa, Toxicologie , ToxicitToxicology, Toxicology--methods, Poisoning, Poisons,

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Page iPRINCIPLES AND METHODS OF TOXICOLOGY

Fourth Edition

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Page iii PRI NCI PLES AND METHODS OF TOXI COLOGY

Fourth Edition

A.Wallace Hayes Edited byVice President

Corporate Product IntegrityThe Gillette Company

Boston, Massachusetts

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This edition published in the Taylor & Francis e-Library, 2005.Page iv

eBooks please go to www.eBookstore.tandf.co.uk.To purchase your own copy of this or any of Taylor & Francis or Routledges collection of thousands of USA

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Copyright 2001 Taylor & Francis. PRI NCI PLES AND METHODS OF TOXI COLOGY, Fourth Edition All rights reserved. Printed in the United States of America.

Except as permitted under the United States Copyright Act of 1976, no part of this publication may be reproduced or distributed in any form or by any means, or stored in a database or retrieval system,

without prior written permission of the publisher.2 3 4 5 6 7 8 9 0

Cover design by Curtis Tow Graphics.A CIP catalog record for this book is available from the British Library.

The paper in this publication meets the requirements of the ANSI Standard Z39.481984 (Permanence of Paper).

Library of Congress Cataloging-in-Publication DataPrinciples and methods of toxicology/[edited] by A.Wallace Hayes.4th ed.

Includes bibliographical references and index. p.; cm.

1. Toxicology. I.Hayes, A.Wallace (Andrew Wallace), 1939 ISBN 1-56032-814-2 (alk. paper) [DNLM: 1. Toxicology-methods. 2. Poisoning. 3. Poisons. 4. Toxicity Tests. QV 600

P957 2000] RA1211.P74 2000

615.9dc21

00037719

ISBN 0-203-36283-7 Master e-book ISBN

ISBN 0-203-37963-2 (OEB Format)ISBN 1-56032-814-2 (Print Edition) (case)

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Page ix Eric D.Clegg, Ph.D.

U.S. Army Center for Environmental Health ResearchFort Detrick, Maryland 217025010

Lorris G.Cockerham, Ph.D., DABFE Phenix Consulting & Services, Ltd.

3006 Hinsen Road

Ralph R.Cook, M.D. Little Rock, Arkansas 722122712RRC Consulting, LLC

1401 Harwood Court

Deborah A.Cory-Slechta, Ph.D. Midland, Michigan 486402765

Department of Environmental MedicineUniversity of RochesterSchool of Medicine

Rochester, New York 14642575 Elmwood Avenue, Box EHSC

University of Kentucky Peter A.Crooks, Ph.D.

Room 501ACollege of Pharmacy

Rose Street

Cham E.Dallas, Ph.D. Lexington, Kentucky 405360082Director, Interdisciplinary Toxicology Program

Athens, Georgia 30602University of Georgia Mary E.Davis, Ph.D.

Department of Pharmacology and ToxicologyWest Virginia University Health Sciences CenterP.O. Box 9223

Jack H.Dean, Ph.D., D.A.B.T. Morgantown, West Virginia 265069223

A Division of Sanofi-Synthelabo, Inc.Sanofi-Synthelabo Research9 Great Valley Parkway

J.Donald deBethizy, Ph.D., D.A.B.T. Malvern, Pennsylvania 19355Targacept, Inc.

P.O. Box 1487

Louis C.DiPasquale, M.S. Winston-Salem, North Carolina 271021487The Gillette Company

Gillette Medical Evaluation Laboratories

401 Professional Drive

Michael A.Dorato, Ph.D., D.A.B.T. Gaithersburg, Maryland 20879Director, Toxicology Projects and Environmental Sciences

A Division of Eli Lilly and CompanyLilly Research LaboratoriesP.O. Box 708

Anne Fairbrother, D.V.M., Ph.D. Greenfield, Indiana 46140

Corvallis, Oregon 97333Parametrix, Inc.

University of Maryland Bruce A.Fowler, Ph.D., FATS

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Toxicology Program1450 South Rolling Road

Shayne C.Gad, Ph.D., D.A.B.T. Baltimore, Maryland 21227Gad Consulting Services

1818 White Oak Road

Raleigh, North Carolina 27608 David W.Gaylor, Ph.D.

Sciences International Inc.

Suite 5001800 Diagonal Road

Alexandria, VA 223142808

Department of Biochemistry and Center in Molecular Toxicology F.Peter Guengerich, Ph.D.

Nashville, Tennessee 372320146Vanderbilt University School of Medicine

Chesapeake Biological Laboratory Mary L.Haasch, Ph.D.

One William StreetUniversity of Maryland

P.O. Box 38

Solomons, Maryland 206880038

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Contents Page v

Acknowledgments Contributing Authors Foreword to the Third Edition by Ted Loomis, M.D., Ph.D

Foreword to the Fourth Edition by W.E.Waddell, M.D Preface to the Second Edition

Preface to the Third Edition

Preface to the Fourth Edition

viii xiii xiv

xv xvi xvii xix

Part I : Principles of Toxicology

1 The Art, the Science, and the Seduction of Toxicology: An Evolutionary Development

2 The Use of Toxicology in the Regulatory ProcessJoseph F.Borzelleca

3 Metabolism: A Determinant of ToxicityBarbara D.Beck, Tracey M.Slayton, Edward J.Calabrese, Linda Baldwin, and Ruthann Rudel

4 Toxicokinetics: Pharmacokinetics in ToxicologyJ.Donald deBethizy and Johnnie R.HayesAndrew Gordon Renwick

5 Physiologically Based Pharmacokinetic Modeling in ToxicologyKannan Krishnan and Melvin E.Andersen

6 The Toxicological Assessment of Pharmaceutical and Biotechnology Products

7 Statistics for ToxicologistsMichael A.Dorato and Mary Jo Vodicnik

8 Quantitative Extrapolations in ToxicologyShayne C.Gad