Humphrey - Neoplastic Mimics in Genitourinary Pathology

Pathology of Neoplastic Mimics Series

Mark R. Wick and Peter A. Humphrey

Series Editors

Dermatopathology
Mark R. Wick and James W. Patterson

Thoracic and Cardiovascular Pathology
Mark R. Wick and Henry D. Tazelaar

Genitourinary Pathology
Peter A. Humphrey, J. Carlos Manivel, and Robert H. Young

Forthcoming Volumes

Breast Pathology

Gastrointestinal and Liver Pathology

Gynecologic Pathology

Bone and Soft Tissue Pathology

Peter A. Humphrey, MD, PhD

Ladenson Professor of Pathology and Immunology

Chief Division of Anatomic and Molecular Pathology

Barnes-Jewish Hospital

Washington University School of Medicine

St. Louis, Missouri

J. Carlos Manivel, MD

Professor of Pathology and Urology

University of Minnesota

Veterans Administration Medical Center

Minneapolis, Minnesota

Robert H. Young, MD, FRCPath

Robert E. Scully Professor of Pathology

Director of Gynecological and Urological Pathology

Massachusetts General Hospital, Harvard Medical School

Boston, Massachusetts

Visit our website at www.demosmedpub.com

ISBN: 978-1-620700-20-4
e-book ISBN: 978-1-617051-83-8

Acquisitions Editor: Rich Winters
Compositor: diacriTech

2014 Demos Medical Publishing, LLC. All rights reserved. This book is protected by copyright. No part of it may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher.

Medicine is an ever-changing science. Research and clinical experience are continually expanding our knowledge, in particular our understanding of proper treatment and drug therapy. The authors, editors, and publisher have made every effort to ensure that all information in this book is in accordance with the state of knowledge at the time of production of the book. Nevertheless, the authors, editors, and publisher are not responsible for errors or omissions or for any consequences from application of the information in this book and make no warranty, expressed or implied, with respect to the contents of the publication. Every reader should examine carefully the package inserts accompanying each drug and should carefully check whether the dosage schedules mentioned therein or the contraindications stated by the manufacturer differ from the statements made in this book. Such examination is particularly important with drugs that are either rarely used or have been newly released on the market.

Library of Congress Cataloging-in-Publication Data

Humphrey, Peter A., author.

Neoplastic mimics in genitourinary pathology / Peter A. Humphrey, J. Carlos Manivel, Robert H. Young.

p. ; cm.(Pathology of neoplastic mimics series)

Includes bibliographical references and index.

ISBN 978-1-62070-020-4ISBN 978-1-61705-183-8 (e-book)

I. Manivel, Carlos, author. II. Young, Robert H. (Robert Henry), 1950 author. III. Title. IV. Series: Pathology of neoplastic mimics series.

[DNLM: 1. Male Urogenital Diseasesdiagnosis. 2. Urogenital Neoplasmspathology. 3. Diagnosis, Differential. 4. Male Urogenital Diseasespathology. WJ 160]

RC280.G52

616.9946dc23

2013028152

Special discounts on bulk quantities of Demos Medical Publishing books are available to corporations, professional associations, pharmaceutical companies, health care organizations, and other qualifying groups. For details, please contact:

Special Sales Department

Demos Medical Publishing, LLC

11 West 42nd Street, 15th Floor

New York, NY 10036

Phone: 800-532-8663 or 212-683-0072

Fax: 212-941-7842

E-mail:

Printed in the United States of America by Courier.
13 14 15 16 17 / 5 4 3 2 1

Mark R. Wick

Peter A. Humphrey

Peter A. Humphrey and Robert H. Young

Peter A. Humphrey and Robert H. Young

J. Carlos Manivel, Arbaz Samad, Charanjeet Singh, and Mark R. Wick

Arbaz Samad, MD

Oncologic Pathology Fellow

Department of Pathology

Memorial Sloan-Kettering Cancer Center

New York, New York

Charanjeet Singh, MD

Fellow

Division of Cytopathology

Department of Pathology & Laboratory Medicine

University of Texas MD Anderson Cancer Center

Houston, Texas

Mark R. Wick, MD

Professor of Pathology

Associate Director of Surgical Pathology

University of Virginia Health System

Charlottesville, Virginia

One of the most challenging and humbling aspects of surgical pathology practice is the well-known ability for disparate biological processes and diseases to resemble one another morphologically. This capacity for mimicry is seen within nonneoplastic and neoplastic processes. More problematically, and as discussed in this atlas, it is possible for nonneoplastic conditions to assume the guises of neoplasms at a macroscopic level, a microscopic one, or both. When that occurs, there is a real danger that pathologists will misinterpret these benign lesions, and incorrect treatment may result. It is critical that the diagnostic surgical pathologist generate a mental checklist of those pseudoneo-plasms that can simulate malignancy, so that before diagnosing a neoplasm, the diagnostician rules out a benign lesion.

This book discusses and illustrates, in a comprehensive fashion, the many faces of these pseudoneoplasms in the genitourinary tract. It is important to appreciate the spectrum of appearance of these pseudoneoplasms, and accordingly this book provides, for many entities, several different images along that spectrum.

To make the life of the pathologist even more difficult, the converse issue may arise, namely deceptively benign appearing malignancies can be misdiagnosed as benign. In this book, these pseudoneoplasms and deceptively benign-appearing malignancies are discussed and illustrated together, often side-by-side.

It is our hope that this type of format will be a diagnostic aid for those who see these often challenging cases, with a reduction in errors in diagnosis.

Thanks to my wife Kay for unwavering support and understanding and to colleagues in Pathology and Urology at Washington University Medical Center. Special thanks to Dr. Robin Vollmer, who inspired my interest in genitourinary pathology, and to Dr. Mark Wick, who created the concept of a book focused on pseudoneoplasms. PAH

I am greatly indebted and profoundly grateful to the patients who have taught me over the years; the correct answer is always theirs. JCM

To my wife Terry for all her help and encouragement over the years and to our wonderful daughters Jessica and Jennifer for their understanding. As always I am indebted to the late Dr. Robert E. Scully for all he taught me and his great example. Thanks also to the other two great associates of my professional career, Dr. Philip B. Clement and Dr. Esther Oliva, for all they have done to enrich my academic life. RHY