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I Barry Holland - ABC Proteins. From Bacteria to Man

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ABC Proteins is an in-depth, up-to-date analysis of all that is known about the subject to date. It discusses and compares evolution, biology and mechanism of action of all known ABC proteins, including the first structural studies as well as clinical implications. It will be useful to anyone trying to stay abreast of the latest findings. This book is sure to become a classic and will regularly be updated.

Key Features

  • Phylogeny and Evoloution of ABC Transporters
    • Fundamental Aspects of the Mechanism of Action of ABC Transporters
    • Prokaryote ABC Transporters
    • Non-Mammalian Transporters
    • Multidrug Transporters
    • ABC Transporters, Physiological Roles and Human Disease
    • Full color throughout
  • I Barry Holland: author's other books


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    ABC PROTEINS
    FROM BACTERIA TO MAN

    I. Barry Holland

    Susan P.C. Cole

    Karl Kuchler

    Christopher F. Higgins

    Copyright This book is printed on acid-free paper which is a US Government - photo 1

    Copyright

    This book is printed on acid-free paper.

    which is a US Government work in the public domain and not subject to copyright

    All rights reserved.

    No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher.

    Academic Press

    An Imprint of Elsevier Science

    84 Theobalds Road, London WC1X 8RR, UK

    http://www.academicpress.com

    Academic Press

    An Imprint of Elsevier Science

    525 B Street, Suite 1900, San Diego, California 92101-4495, USA

    http://www.academicpress.com

    ISBN 0-12-352551-9

    Library of Congress Catalog Number: 2002103782

    A catalogue record for this book is available from the British Library

    Cover acknowledgments

    Left: Scanning electron micrograph of bacterial cells.

    Centre: An Arabidopsis plasma membrane-localized multispecific ATP-binding cassette transporter, AtMRP4, extrudes glutathione-conjugates and confers tolerance to organic xenobiotics.

    Courtesy of Mingsheng Peng, Sixue Chen, Roco Snchez-Fernndez, Honglan Gu, Shun Liang and Philip A. Rea, Plant Science Institute, Department of Biology, University of Pennsylvania.

    ). Commissioned from Barking Dog Art, Gloucestershire.

    Designed by Elaine C Monaghan

    )

    Typeset by Charon Tec Pvt. Ltd, Chennai, India

    Printed and bound in Hong Kong by RDC

    02 03 04 05 06 07 RD 9 8 7 6 5 4 3 2 1

    CONTRIBUTORS

    , Columbia University, Departments of Ophthalmology and Pathology, Eye Institute Research Rm 715, 630 West 168th Street, New York, NY 10032, USA

    , Howard Hughes Medical Institute and The Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 802 PCTB, 725 N. Wolfe St, Baltimore, MD 21205, USA

    , University Laboratory of Physiology, University of Oxford, Parks Road, Oxford OX1 3PT, UK

    , Cancer Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA

    , Institute of Medical Biochemistry, Department of Molecular Genetics, University and BioCenter of Vienna, Dr. Bohr-Gasse 9/2, A-1030, Vienna Austria

    , Institut de Gntique et Microbiologie, Universit de Paris-Sud, 91405 Orsay Cedex, France

    , Institut de Gntique et Microbiologie, Universit de Paris-Sud, 91405 Orsay Cedex, France

    , The Netherlands Cancer Institute, Division of Molecular Biology and Center for Biomedical Genetics, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands

    , Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK

    , Centre dImmunologie de Marseille, Luminy INSERM-CNRS-Universit de la, Mediterrane, Case 906, Parc Scientifique de Luminy, 13288 Marseille Cedex 09, France

    , The Scripps Research Institute, Department of Molecular Biology, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA

    , Plant Science Institute, Department of Biology, University of Pennsylvania, Philadelphia, PA 19104-6018, USA

    , Centre dImmunologie de Marseille, Luminy INSERM-CNRS-Universit de la, Mediterrane, Case 906, Parc Scientifique de Luminy, 13288 Marseille Cedex 09, France

    , Division of Cancer Biology and Genetics, Queens University Cancer Research Institute, Kingston, Ontario, Canada K7L 3N6

    , Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, D-69120 Heidelberg, Germany

    , Unit de Programmation Molculaire et, Toxicologie gntique, CNRS URA 1444 Dpartement des, Biotechnologies, Institut Pasteur, 25 Rue du Dr Roux, 75724 Paris Cedex 15, France

    , Human Genetics Section, Laboratory of Genomic Diversity, Bld. 560, Rm 21-18, National Cancer Institute-Frederick, Frederick, MD 21702, USA

    , Division of Cancer Biology and Genetics, Queens University Cancer Research Institute, Kingston, Ontario, Canada K7L 3N6

    , Institut de Gntique et Microbiologie, Universit de Paris-Sud, 91405 Orsay Cedex, France

    , Cardiovascular Research Institute, University of California, San Francisco, CA 94143-0130, USA

    , Laboratory for Molecular Physiology, Institute of Plant Sciences, University of Zurich, Zolikerstrasse 107, 8008 Zurich, Switzerland

    , Mayo Foundation and S.C. Johnson Medical Research Center, Mayo Clinic, Scottsdale, AZ 85259, USA

    , Department of Physiology, McGill University, Montral, Qubec, Canada, H3G 1Y6

    , MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, Du Cane Rd, London W12 0NN, UK

    , Institut de Gntique et Microbiologie, Universit de Paris-Sud, 91405 Orsay Cedex, France

    , Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, D-69120 Heidelberg, Germany

    , School of Biomedical Sciences, Medical School, University of Nottingham, Nottingham NG7 2UH, UK

    , Institute of Biochemistry, Medical Faculty, University of Pecs, Szigeti ut 12, 7624 Pecs, Hungary

    , Laboratory for Molecular Physiology, Institute of Plant Sciences, University of Zurich, Zolikerstrasse 107, 8008 Zurich, Switzerland

    , Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, D-69120 Heidelberg, Germany

    , Department of Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, NL-9751 NN Haren, The Netherlands

    , Institute of Medical Biochemistry, Department of Molecular Genetics, University and BioCenter of Vienna, Dr. Bohr-Gasse 9/2, A-1030 Vienna, Austria

    , Institut fr Physiologische Chemie, Klinikum, Universitt Marburg, Karl-von-Frisch-Str. 1, D-35043 Marburg, Germany

    , Centre de Recherche en Infectiologie and Dpartement de Biologie mdicale, Universit Laval, 2705, boul. Laurier, Sainte-Foy, QC, Canada G1V 4G2

    , Institut fr Zytobiologie und Zytopathologie der Philipps-Universitt, Marburg, Robert-Koch-Str. 5, 35033 Marburg, Germany

    , MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, Du Cane Rd, London W12 0NN, UK

    , Laboratory for Molecular Physiology, Institute of Plant Sciences, University of Zurich, Zolikerstrasse 107, 8008 Zurich, Switzerland

    , University Laboratory of Physiology, University of Oxford, Parks Road, Oxford OX1 3PT, UK

    , Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, D-69120 Heidelberg, Germany

    , Academic Medical Center, Laboratory for Experimental Hepatology, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

    , Centre de Recherche en Infectiologie and Dpartement de Biologie mdicale, Universit Laval, 2705, boul. Laurier, Sainte-Foy, QC, Canada G1V 4G2

    , Plant Science Institute, Department of Biology, University of Pennsylvania, Philadelphia, PA 19104-6018, USA

    , College of Pharmacy, PHR 4.116, University of Texas at Austin, Austin, Texas 78712, USA

    , Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands

    , Plant Science Institute, Department of Biology, University of Pennsylvania, Philadelphia, PA 19104-6018, USA

    , The Netherlands Cancer Institute, Division of Molecular Biology and Center for Biomedical Genetics, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands

    , Mayo Foundation and S.C. Johnson Medical Research, Center, Mayo Clinic, Scottsdale, AZ 85259, USA

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