Caroline S. Zeind PharmD - Applied Therapeutics: The Clinical Use of Drugs

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Eleventh edition

Copyright 2018 Wolters Kluwer.

Copyright 2013, 2009, 2005 by LIPPINCOTT WILLIAMS & WILKINS, a WOLTERS KLUWER business All rights reserved. This book is protected by copyright. No part of this book may be reproduced or transmitted in any form or by any means, including as photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. To request permission, please contact Wolters Kluwer at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at (products and services).

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Library of Congress Cataloging-in-Publication Data

Names: Zeind, Caroline S., editor. | Carvalho, Michael G., editor.

Title: Applied therapeutics : the clinical use of drugs / [edited by]

Caroline S. Zeind, Michael G. Carvalho.

Other titles: Applied therapeutics for clinical pharmacists.

Description: Eleventh edition. | Philadelphia : Wolters Kluwer Health, [2018]

| Includes bibliographical references and index.

Identifiers: LCCN 2017045052 | eISBN 9781496396075 | VST 9781496396082

Subjects: | MESH: Drug Therapy

Classification: LCC RM262 | NLM WB 330 | DDC 615.5/8dc23 LC record available at

https://lccn.loc.gov/2017045052

This work is provided as is, and the publisher disclaims any and all warranties, express or implied, including any warranties as to accuracy, comprehensiveness, or currency of the content of this work.

This work is no substitute for individual patient assessment based upon healthcare professionals examination of each patient and consideration of, among other things, age, weight, gender, current or prior medical conditions, medication history, laboratory data and other factors unique to the patient. The publisher does not provide medical advice or guidance and this work is merely a reference tool. Healthcare professionals, and not the publisher, are solely responsible for the use of this work including all medical judgments and for any resulting diagnosis and treatments.

Given continuous, rapid advances in medical science and health information, independent professional verification of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options should be made and healthcare professionals should consult a variety of sources. When prescribing medication, healthcare professionals are advised to consult the product information sheet (the manufacturers package insert) accompanying each drug to verify, among other things, conditions of use, warnings and side effects and identify any changes in dosage schedule or contraindications, particularly if the medication to be administered is new, infrequently used or has a narrow therapeutic range. To the maximum extent permitted under applicable law, no responsibility is assumed by the publisher for any injury and/or damage to persons or property, as a matter of products liability, negligence law or otherwise, or from any reference to or use by any person of this work.

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The editors wish to express their sincere thanks to Dr. Mary Anne Koda-Kimble and Dr. Lloyd Young who created Applied Therapeutics, the gold standard textbook used in the teaching of patient-centered drug therapeutics. Their vision and legendary contributions have inspired generations of health profession students, faculty, and clinicians. We are grateful to the past editors and current editorial team and contributors, as well as faculty colleagues and clinicians across the globe for their tremendous dedication to their patients and their communities. They have shaped and inspired the next generation of health care professionals through innovative teaching, mentoring, and dissemination of their scholarship. Finally, we wish to thank our families for their patience and understanding as we embarked on this journey and completed this eleventh edition of the textbook.

It has been over forty years since the first edition of Applied Therapeutics: The Clinical Use of Drugs was published, and the landscape of health care has changed dramatically. While we have seen tremendous scientific and technologic advancements transform personalized medicine, we also realize the significant challenges that we face within our increasingly complex health care delivery system. More than ever, we are in need of health professionals who are able to think critically and to utilize problem-solving skills to improve patient outcomes. Approximately four decades later, the founding principle for this textbooka patient-centric, case-based approach to learningremains the cornerstone of health professions education. Our authors present approximately 900 patient cases that stimulate the reader to integrate and apply therapeutic principles in the context of specific clinical situations. Health profession students and practitioners gain a glimpse into the minds of clinicians as they work to assess and solve therapeutic problems and develop their own critical-thinking and problem-solving skills.

Readers familiar with past editions of the book will notice that the overall design of the book is consistent with the tenth edition, which incorporates a Core Principles section at the beginning of each chapter, providing the most important take home information from the chapter. Each Core Principle is mapped to specific cases within the chapter where the principle is discussed in detail. Key references and websites are listed at the end of each chapter, whereas the full reference lists for each chapter have been moved online.

Building upon the excellent foundation of case-based learning provided in previous editions, the eleventh edition has incorporated changes to meet the evolving educational needs of health profession educators and students across the globe. The editors and contributors have utilized the five Institute of Medicine (IOM) core competencies as a broad framework for proposing case studies and questions within the textbook: patient-centered care; interdisciplinary teams; evidence-based practice; quality improvement; and informatics. In addition, the Accreditation Council for Pharmacy Education (ACPE) Accreditation Standards 2016, the Center for the Advancement of Pharmacy Education (CAPE) Educational Outcomes, and the North American Pharmacist Licensure Examination (NAPLEX) revised competency statements have served as road maps for the editorial team and contributors in designing the eleventh edition.