Laurence Brunton - Goodman and Gilmans The Pharmacological Basis of Therapeutics, Twelfth Edition

Goodman & Gilmans
The Pharmacological Basis of THERAPEUTICS

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twelfth edition

editor

Laurence L. Brunton, PhD

Professor of Pharmacology and Medicine
School of Medicine, University of California, San Diego
La Jolla, California

associate editors

Bruce A. Chabner, MD

Professor of Medicine
Harvard Medical School
Director of Clinical Research
Massachusetts General Hospital Cancer Center
Boston, Massachusetts

Bjrn C. Knollmann, MD, PhD

Professor of Medicine and Pharmacology
Oates Institute for Experimental Therapeutics
Division of Clinical Pharmacology
Vanderbilt University School of Medicine
Nashville, Tennessee

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ISBN: 978-0-07-176939-6
MHID: 0-07-176939-0

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In Memoriam

Keith L. Parker

(1954-2008)

SECTION I
General Principles

Suzanne M. Rivera and Alfred Goodman Gilman

Iain L. O. Buxton and Leslie Z. Benet

Donald K. Blumenthal and James C. Garrison

Kevin C. Osterhoudt and Trevor M. Penning

Kathleen M. Giacomini and Yuichi Sugiyama

Frank J. Gonzalez, Michael Coughtrie, and Robert H. Tukey

Mary V. Relling and Kathleen M. Giacomini

SECTION II
Neuropharmacology 169

Thomas C. Westfall and David P. Westfall

Joan Heller Brown and Nora Laiken

Palmer Taylor

Ryan E. Hibbs and Alexander C. Zambon

Thomas C. Westfall and David P. Westfall

Elaine Sanders-Bush and Lisa Hazelwood

Perry B. Molinoff

James M. ODonnell and Richard C. Shelton

Jonathan M. Meyer

S. John Mihic and R. Adron Harris

Tony L. Yaksh and Mark S. Wallace

Piyush M. Patel, Hemal H. Patel, and David M. Roth

William A. Catterall and Kenneth Mackie

James O. McNamara

David G. Standaert and Erik D. Roberson

Marc A. Schuckit

Charles P. OBrien

SECTION III
Modulation of Cardiovascular Function

Robert F. Reilly and Edwin K. Jackson

Randa Hilal-Dandan

Thomas Michel and Brian B. Hoffman

Bradley A. Maron and Thomas P. Rocco

Kevin J. Sampson and Robert S. Kass

Jeffrey I. Weitz

Thomas P. Bersot

SECTION IV
Inflammation, Immunomodulation, and Hematopoiesis

Randal A. Skidgel, Allen P. Kaplan, and Ervin G. Erds

Emer M. Smyth, Tilo Grosser, and Garret A. FitzGerald

Tilo Grosser, Emer M. Smyth, and Garret A. FitzGerald

Alan M. Krensky, William M. Bennett, and Flavio Vincenti

Peter J. Barnes

Kenneth Kaushansky and Thomas J. Kipps

SECTION V
Hormones and Hormone Antagonists

Keith L. Parker and Bernard P. Schimmer