Dawn Merton Boothe DVM MS PhD DACVIM DACVCP - Small Animal Clinical Pharmacology and Therapeutics, 2nd Edition

Small Animal Clinical Pharmacology & Therapeutics

Second Edition

Dawn Merton Boothe, DVM, MS, PhD, DACVIM, DACVP

Professor, Department of Physiology and Pharmacology, College of Veterinary Medicine

Director, Clinical Pharmacology Laboratory, Auburn University, Auburn, Alabama

Copyright 2012, 2001 by Elsevier Inc.

Saunders

Front Matter

Second Edition

Copyright

3251 Riverport Lane

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SMALL ANIMAL CLINICAL PHARMACOLOGY AND THERAPEUTICS ISBN: 978-0-7216-0555-5

Copyright 2012, 2001 by Saunders, an imprint of Elsevier Inc.

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Notice

Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary.

Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility.

With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions.

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Library of Congress Cataloging-in-Publication Data

Small animal clinical pharmacology and therapeutics/[edited by] Dawn Merton Boothe. -- 2nd ed.

p.; cm.

Rev. ed. of: Small animal clinical pharmacology and therapeutics/Dawn Merton Boothe. c2001.

Includes bibliographical references and index.

ISBN 978-0-7216-0555-5 (pbk.: alk. paper) 1. Dogs--Diseases--Treatment. 2. Cats--Diseases--Treatment. 3. Veterinary pharmacology.

I. Boothe, Dawn Merton. II. Boothe, Dawn Merton. Small animal clinical pharmacology and therapeutics.

[DNLM: 1. Dog Diseases--drug therapy. 2. Cat Diseases--drug therapy. 3. Veterinary Drugs. SF 991]

SF991.B676 2012

636.7'0895--dc22 2011004138

Vice President and Publisher: Linda Duncan

Acquisitions Editor: Heidi Pohlman

Senior Developmental Editor: Shelly Stringer

Publishing Services Manager: Julie Eddy

Senior Project Manager: Celeste Clingan

Design Direction: Margaret Reid

Printed in the United States of America

Last digit is the print number: 9 8 7 6 5 4 3 2 1

Contributors

Paul R. Avery, VMD, PhD, Associate Professor, Department of Microbiology, Immunology and Pathology College of Veterinary Medicine, Colorado State University, Fort Collins, Colorado

Biologic Response Modifiers: Interferons, Interleukins, Recombinant Products, and Liposomal Products

Ellen N. Behrend, VMD, PhD, DACVIM, Professor, Department of Clinical Sciences College of Veterinary Medicine, Auburn University, Auburn, Alabama

Drug Therapy for Endocrinopathies

Harry W. Boothe, DVM, Professor, Department of Clinical Sciences College of Veterinary Medicine, Auburn University, Auburn, Alabama

Disinfectants, Antiseptics, and Related Biocides

Janice L. Cain, DVM, DACVIM, Staff Veterinarian, Bishop Ranch Veterinary Center, San Ramon, California

Rational Use of Reproductive Hormones

Tanya D. Civco, DVM, DACVIM, Associate Professor, Department of Clinical Sciences College of Veterinary Medicine, Auburn University, Auburn, Alabama

Drug Therapy for Endocrinopathies

Tad B. Coles, DVM, Institutional Animal Care and Use Committee Veterinarian, Research and Graduate Studies, Kansas University, Lawrence, Kansas, Freelance Medical Writing and Regulatory Consulting, Overland Park, Kansas

Drugs for the Treatment of Helminth Infections Anthelmintics

Autumn P. Davidson, DVM, MS, DACVIM, Clinical Professor Department of Medicine and Epidemiology, School of Veterinary Medicine University of California, Davis, California, Staff Internist, Department of Internal Medicine, VCA Animal Care Center of Sonoma, Rohnert Park, California

Rational Use of Reproductive Hormones

Reid P. Groman, DVM, DACVIM, DACVECC, Department of Clinical Studies School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

Fluids, Electrolytes, and Acid-Base Therapy

Sophie A. Grundy, BVSc (Hons), MACVSc, DACVIM, Graduate Student Researcher, Department of Population Health and Reproduction University of California, Davis, California, Veterinarian, Internal Medicine and Reproduction, VCA Sacramento Animal Medicine Group, Carmichael, California

Rational Use of Reproductive Hormones

Robert A. Kennis, DVM, MS, DACVD, Associate Professor, Department of Clinical Sciences College of Veterinary Medicine, Auburn University, Auburn, Alabama

Dermatologic Therapy

India F. Lane, DVM, MS, EdD, Associate Professor of Medicine Director of Educational Enhancement, Department of Small Animal Clinical Sciences College of Veterinary Medicine, The University of Tennessee, Knoxville, Tennessee, Internist, W.W. Armistead Veterinary Teaching Hospital College of Veterinary Medicine, The University of Tennessee, Knoxville, Tennessee

Treatment of Urinary Disorders

Randy C. Lynn, DVM, MS, DACVP, Director, Professional Services Group, IDEXX Pharmaceuticals, Inc., Greensboro, North Carolina