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Schlossberg David L. - A Guide to Commonly Used Antimicrobials

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Table of Contents Guide Pages Antibiotics Manual A Guide to Commonly Used - photo 1
Table of Contents
Guide
Pages
Antibiotics Manual
A Guide to Commonly Used Antimicrobials

Second Edition

David Scholssberg MD, FACP, FIDSA, FCPP

The Lewis Katz School of Medicine at Temple University Philadelphia, PA, USA

Rafik Samuel, MD, FACP, FIDSA, FCPP

The Lewis Katz School of Medicine at Temple University Philadelphia, PA, USA

This edition first published 2017 2017 John Wiley Sons Ltd Edition History - photo 2

This edition first published 2017
2017 John Wiley & Sons Ltd

Edition History
PMPHUSA, Ltd (1e, 2011)

All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions.

The right of David Schlossberg and Rafik Samuel to be identified as the author(s) of this work has been asserted in accordance with law.

Registered Office(s)
John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, USA
John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK

Editorial Office
9600 Garsington Road, Oxford, OX4 2DQ, UK

For details of our global editorial offices, customer services, and more information about Wiley products visit us at www.wiley.com.

Wiley also publishes its books in a variety of electronic formats and by printondemand. Some content that appears in standard print versions of this book may not be available in other formats.

Limit of Liability/Disclaimer of Warranty
The contents of this work are intended to further general scientific research, understanding, and discussion only and are not intended and should not be relied upon as recommending or promoting scientific method, diagnosis, or treatment by physicians for any particular patient. In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of medicines, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each medicine, equipment, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. While the publisher and authors have used their best efforts in preparing this work, they make no representations or warranties with respect to the accuracy or completeness of the contents of this work and specifically disclaim all warranties, including without limitation any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives, written sales materials or promotional statements for this work. The fact that an organization, website, or product is referred to in this work as a citation and/or potential source of further information does not mean that the publisher and authors endorse the information or services the organization, website, or product may provide or recommendations it may make. This work is sold with the understanding that the publisher is not engaged in rendering professional services. The advice and strategies contained herein may not be suitable for your situation. You should consult with a specialist where appropriate. Further, readers should be aware that websites listed in this work may have changed or disappeared between when this work was written and when it is read. Neither the publisher nor authors shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages.

Library of Congress CataloginginPublication Data

Names: Schlossberg, David, author. | Samuel, Rafik, author.
Title: Antibiotics manual : a guide to commonly used antimicrobials / by David Schlossberg, Rafik Samuel.
Description: Second edition. | Hoboken, NJ : Wiley, 2017. | Includes bibliographical references and index.
Identifiers: LCCN 2017028213 (print) | LCCN 2017029407 (ebook) | ISBN 9781119220770 (pdf) | ISBN 9781119220763 (epub) | ISBN 9781119220756 (pbk.)
Subjects: | MESH: AntiBacterial Agentsadministration & dosage | AntiBacterial Agentstherapeutic use | Handbooks
Classification: LCC RM267 (ebook) | LCC RM267 (print) | NLM QV 39 | DDC 615/.329dc23
LC record available at https://lccn.loc.gov/2017028213

Cover Design: Wiley
Cover Image: everything possible/Shutterstock

Once again, for Yuan:

Shall I compare thee to a summers day?
Thou art more lovely and more temperate.
Rough winds do shake the darling buds of May,
And summers lease hath all too short a date.
.
But thy eternal summer shall not fade,
Nor lose possession of that fair thou owst

Shakespeare, Sonnet 18.

David Schlossberg

This book is dedicated to my family, Farid, Leila, Dalia, Ed, and Matt. Thank you all; you are the reason I am the person I am today.

Rafik Samuel

PREFACE

We are pleased to present the Second Edition of our book. The development of new antimicrobials since the First Edition has been explosive, necessitating the addition of 36 new chapters, comprising new antiretroviral, antiHCV, antimycobacterial, antifungal and antibacterial drugs and combinations. All the older chapters have been updated as necessary, and new tables have been added that highlight salient antimicrobial toxicities and indicate potential specific coverage of difficult pathogens.

As with the First Edition, we intend this book to fill an important particular niche in the clinicians arsenal: it is a compilation of individual brief chapters, each dedicated to a specific antimicrobial. The final chapter of formulas, equations, and useful definitions now also includes the toxicity and coverage tables mentioned above. Each antimicrobial chapter lists the drugs class, mechanism of action, mechanism of resistance, metabolic route, indications and offlabel uses, pertinent toxicities, significant drug interactions, and dosage for routine and special populations. The emphasis of this book is not on recommendations for specific organisms or clinical syndromes; rather, it is a compendium of clinically helpful information about available antimicrobials.

We have included the FDAapproved indications as they exist currently; additional offlabel uses are also included. For many agents, the toxicities and drug interactions are numerous and complex; frequently, the clinician must research several sites or even multiple locations in the drug label itself to identify significant toxicities. We have tried to organize the most frequent and important toxicities and drug interactions in a convenient, userfriendly format.

Dosage information includes the special populations of renal failure, hepatic dysfunction, and pediatrics, and each chapter concludes with a list of clinical pearls, adding practical tips to the preceding discussion. When possible, we have used the official drug label as a primary source of information, supplemented by the various print and electronic sources in the References; further details may be sought in these resources.

In addition to FDAapproved indications, we have also listed offlabel uses of selected agents; further, since many of the antiparasitic drugs are difficult to acquire in the United States, we have supplied relevant contact information for the CDC or compounding pharmacies, when appropriate.

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