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Ashutosh Kumar Shukla - Nanoparticles and their Biomedical Applications

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Ashutosh Kumar Shukla Nanoparticles and their Biomedical Applications
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Nanotechnology is expected to bring revolutionary changes in a variety of fields. This volume describes nanoparticles and their biomedical applications, and covers metal nanoparticles, metal oxide nanoparticles, rare earth based nanoparticles and graphene oxide nanoparticles. It elaborates on a number of biomedical applications, including therapeutic applications. It addresses the topic of green synthesis, in view of increasing health and environmental concerns.

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Editor Ashutosh Kumar Shukla Nanoparticles and their Biomedical Applications - photo 1
Editor
Ashutosh Kumar Shukla
Nanoparticles and their Biomedical Applications
Editor Ashutosh Kumar Shukla Physics Department Ewing Christian College - photo 2
Editor
Ashutosh Kumar Shukla
Physics Department, Ewing Christian College, Prayagraj, Uttar Pradesh, India
ISBN 978-981-15-0390-0 e-ISBN 978-981-15-0391-7
https://doi.org/10.1007/978-981-15-0391-7
Springer Nature Singapore Pte Ltd. 2020
This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.
The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd.

The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore

To my parents

Preface

This collection intends to highlight the potential applications of nanoparticles in the field of medicine. Rare-earth based nanoparticles, metal-oxide nanoparticles, metal nanoparticles, graphene oxide and lignin based nanoparticles have been covered in different chapters. Ecofriendly greener synthesis approaches have been given due consideration in view of increasing environmental concerns. Biomedical and bioengineering applications of nanoparticles with impact on health issues and related therapeutic measures have been described.

I am thankful to the expert contributors to manage their time out of their busy schedule. It is only their sincere effort which enabled me to present this volume before the audience. My sincere thanks are due to reviewers from different countries who have contributed a lot to improve the content quality through their constructive comments.

I sincerely thank Dr. Naren Aggarwal and Dr. Gaurav Singh from Springer Nature for giving me the opportunity to present this book. I also thank Ms. Vaishnavi Venkatesh for her support during the production process.

I could learn many things while going through individual chapters and hope that it will be a good experience for the audience too.

Ashutosh Kumar Shukla
Prayagraj, India
October 2019
Contents
Susheel Kumar Nethi , Vishnu Sravan Bollu , Neeraja Aparna Anand P. and Chitta Ranjan Patra
Ezhilarasan Devaraj and S. Rajeshkumar
S. Rajeshkumar and D. Sandhiya
Naumih Noah
Eman Osman
Ayan Kumar Barui , Arpita Roy , Sourav Das , Keerti Bhamidipati and Chitta Ranjan Patra
Douglas Roberto Monteiro , Las Salomo Arias , Heitor Ceolin Araujo , Anne Caroline Morais Caldeiro , Bianca Fiorese Gulart , Joseane de Oliveira , Marilene Batista dos Santos , Gordon Ramage and Juliano Pelim Pessan
Siavash Iravani
Luciano Paulino Silva , Gabriela Mendes da Rocha Vaz , Jlia Moreira Pupe , Liana Soares Chafran , Lucio Assis Araujo Neto , Thas Ribeiro Santiago , Thalita Fonseca Araujo and Vera Lcia Perussi Polez
Swarupa Ghosh and Saptarshi Chatterjee
About the Editor
Ashutosh Kumar Shukla

obtained his B.Sc., M.Sc., and D.Phil. degrees from the University of Allahabad. He has been a University Educator and Researcher for more than 17 years and is currently an Associate Professor of Physics at Ewing Christian College, Prayagraj, a constituent institution of the University of Allahabad. Dr. Shukla has successfully completed numerous research projects and published several edited volumes in collaboration with prominent experts.

Springer Nature Singapore Pte Ltd. 2020
A. K. Shukla (ed.) Nanoparticles and their Biomedical Applications https://doi.org/10.1007/978-981-15-0391-7_1
1. Rare Earth-Based Nanoparticles: Biomedical Applications, Pharmacological and Toxicological Significance
Susheel Kumar Nethi
(1)
Department of Applied Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana State, India
(2)
Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India
Chitta Ranjan Patra
Email:
Abstract

It is well established that nanomaterials play an important role in addressing various unresolved problems in biomedical research. Among these, the rare earth or lanthanide-based metal nanoparticles are increasingly explored for their potential biomedical applications. Several researchers across the globe including us reported the biological applications (magnetic resonance imaging, anticancer, antimicrobial, fluorescence, antioxidant properties) of rare earth-based nanomaterials. Furthermore, in spite of their excellent photoluminescence, magnetic resonance properties, photostability and therapeutic efficacy, there is still an issue of growing concern for the clinical applications of these rare earth nanomaterials. The desirable properties of these elements might also be equally associated with unexpected and biohazardous toxicities. Therefore, many groups have reported the comprehensive toxicity assessment (in vitrocell lines and in vivorodent models) of rare earth nanomaterials. This chapter focuses on the detailed discussion of the biomedical applications of these rare earth-based nanomaterials along with their toxicological evaluation and pharmacokinetics significances. The future opportunities and challenges are also incorporated to highlight the importance for their clinical translation.

Keywords
Biomedical applications Clearance Pharmacokinetics Pharmacology Rare earth-based nanoparticles Toxicology
Abbreviations
786-O

Human renal adenocarcinoma

ALT

Alanine Aminotransferase

AST

Aspartate Aminotransferase

ATP

Adenosine triphosphate

BDNF

Brain-derived neurotropic factor

BEAS-2B

Transformed human bronchial epithelial cells

bFGF

basic fibroblast growth factor

CCl4

Carbon tetrachloride

CeO2

Cerium oxide

CF

ciprofloxacin

CHO

Chinese hamster ovary

CI

Cerebral ischaemia

CNP

Cerium nanoparticle

CPNPs

Coordination polymer nanoparticles

CT

Computed tomography

DNA

Deoxy ribonucleic acid

DOX

Doxorubicin

DU145

Human prostate cancer cell line

Dy2O3

Dysprosium oxide

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