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Cao - Silver nanoparticles for antibacterial devices : biocomparibility and toxicity

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Cao Silver nanoparticles for antibacterial devices : biocomparibility and toxicity
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    Silver nanoparticles for antibacterial devices : biocomparibility and toxicity
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Huiliang Cao earned his PhD in materials science and engineering from South - photo 1

Huiliang Cao earned his PhD in materials science and engineering from South China University of Technology in 2008. After having worked for 2 years as a postdoctoral research scientist and another 2 years as an assistant professor at Shanghai Institute of Ceramics, Chinese Academy of Sciences (SICCAS), in 2012, he was promoted to associate professor. Dr Cao, as a member of the Chinese Society for Biomaterials and the Chinese Mechanical Engineering Society, centres on exploring the cellular responses to materials engineered with distinctive surface or interface properties, especially on developing antibacterial materials with selective toxicity.

Long Bai

Research Institute of Surface Engineering

Taiyuan University of Technology

Taiyuan, China

Uttam C. Banerjee

Department of Pharmaceutical Technology (Biotechnology)

National Institute of Pharmaceutical Education and Research

Punjab, India

Jayeeta Bhaumik

Department of Pharmaceutical Technology (Biotechnology)

National Institute of Pharmaceutical Education and Research

Punjab, India

Huiliang Cao

State Key Laboratory of High Performance Ceramics and Superfine Microstructure

Shanghai Institute of Ceramics

Chinese Academy of Sciences

Shanghai, China

Paul K. Chu

Department of Physics and Materials Science

City University of Hong Kong

Hong Kong, China

Bharat P. Dwivedee

Department of Pharmaceutical Technology (Biotechnology)

National Institute of Pharmaceutical Education and Research

Punjab, India

Ang Gao

Department of Physics and Materials Science

City University of Hong Kong

Hong Kong, China

Denis Girard

Laboratoire de recherche en inflammation et physiologie des granulocytes

Universit du Qubec, INRS-Institut Armand-Frappier

Laval, Quebec, Canada

Yingxin Gu

Department of Oral and Maxillo-facial Implantology

Shanghai Key Laboratory of Stomatology

Shanghai Ninth Peoples Hospital

Shanghai Jiao Tong University

Shanghai, China

Michael R. Hamblin

Wellman Center for Photomedicine

Massachusetts General Hospital

and

Department of Dermatology

Harvard Medical School

Boston, Massachusetts

and

Harvard-MIT Division of Health Sciences and Technology

Cambridge, Massachusetts

Ruiqiang Hang

Research Institute of Surface Engineering

Taiyuan University of Technology

Taiyuan, China

Steffen Foss Hansen

Department of Environmental Engineering

Technical University of Denmark

Lyngby, Denmark

Yan Huang

State Key Laboratory of Bioelectronics

School of Biological Science and Medical Engineering

Southeast University

Nanjing, China

Ying-Ying Huang

Wellman Center for Photomedicine

Massachusetts General Hospital

and

Department of Dermatology

Harvard Medical School

Boston, Massachusetts

Gitika Kharkwal

NAC-SCRT Secretariat

ICMR Headquarters

New Delhi, India

Feng Li

American Advanced Nanotechnology

Houston, Texas

Wirginia Likus

Department of Anatomy

School of Health Science in Katowice

Medical University of Silesia

Katowice, Poland

Xiaoying L

State Key Laboratory of Bioelectronics

School of Biological Science and Medical Engineering

Southeast University

Nanjing, China

Aiga Mackevica

Department of Environmental Engineering

Technical University of Denmark

Lyngby, Denmark

Lin Mei

Key Laboratory of Functional Polymer Materials of Ministry of Education

Institute of Polymer Chemistry

Nankai University

Tianjin, China

and

School of Materials and Chemical Engineering

Zhongyuan University of Technology

Zhengzhou, China

Erchao Meng

School of Material and Chemical Engineering

Zhengzhou University of Light Industry

Zhengzhou, China

Kristel Mijnendonckx

Unit of Microbiology

Expert Group Molecular and Cellular Biology

Belgian Nuclear Research Centre (SCKCEN)

Mol, Belgium

Magdalena Owieja

Jerzy Haber Institute of Catalysis and Surface Chemistry

Polish Academy of Sciences

Krakow, Poland

Tanya S. Peretyazhko

Jacobs, NASA Johnson Space Center

Houston, Texas

Pier Paolo Pompa

Istituto Italiano di Tecnologia

Genoa, Italy

Shichong Qiao

Department of Oral and Maxillo-facial Implantology

Shanghai Key Laboratory of Stomatology

Shanghai Ninth Peoples Hospital

Shanghai Jiao Tong University

Shanghai, China

Loris Rizzello

Department of Chemistry

University College London

London, U.K.

Sulbha K. Sharma

Laser Biomedical Section and Application Division

Raja Ramanna Centre for Advanced Technology

Indore, India

Krzysztof Siemianowicz

Department of Biochemistry

School of Medicine in Katowice

Medical University of Silesia

Katowice, Poland

Neeraj S. Thakur

Department of Pharmaceutical Technology (Biotechnology)

National Institute of Pharmaceutical Education and Research

Punjab, India

Rob Van Houdt

Unit of Microbiology

Expert Group Molecular and Cellular Biology

Belgian Nuclear Research Centre (SCKCEN)

Mol, Belgium

Qingbo Zhang

Department of Chemistry

Rice University

Houston, Texas

Xinge Zhang

Key Laboratory of Functional Polymer Materials of Ministry of Education

Institute of Polymer Chemistry

Nankai University

Tianjin, China

Werner Zimmerli

Basel University Medical Clinic

Liestal, Switzerland

Neeraj S. Thakur , Bharat P. Dwivedee , Uttam C. Banerjee and Jayeeta Bhaumik

Metal nanoparticles have been studied and applied in many areas including the biomedical, agricultural and electronic fields (Mittal et al. 2013). Several products of colloidal silver are already in the market. Research on new, eco-friendly and cheaper methods has been initiated. Biological production of metal nanoparticles has been studied by many researchers owing to the convenience of the method that produces small particles stabilised by protein. However, the mechanism involved in this production has not yet been elucidated, although hypothetical mechanisms have been proposed in the literature (Mittal et al. 2014). Thus, this chapter discusses the various mechanisms provided for the biological synthesis of silver nanoparticles (AgNPs) by plants, fungi and bacteria. One thing that is clear is that the mechanistic aspects in some of the biological systems need more detailed studies.

Research on nanoparticles is currently an area of intense scientific interest owing to a wide variety of potential applications in the biomedical, agricultural, optical and electronic fields (Ravindran et al. 2013; Tran et al. 2013). An important type of material that has been studied is metal nanoparticles because of their physicochemical and optoelectronic properties (Mittal et al. 2013). There are various physical and chemical methods employed for the synthesis of metal nanoparticles (Mittal et al. 2013). However, these methods have certain disadvantages as a result of the involvement of toxic chemicals and radiation. Therefore, research is shifting towards biological methods of synthesis of metal nanoparticles, as these are rapid, cost-effective and eco-friendly.

A constant demand exists for economic, commercially viable as well as environment-friendly synthetic routes to nanoparticles (Mittal et al. 2013). Bio-enthused synthesis of nanoparticles provides advantages over chemical and physical methods as it is environmentally-friendly, does not need high pressure and high temperature and no toxic chemicals are needed in biological methods (Mittal et al. 2014). Biomaterials such as bacteria, yeast, fungi and various parts of plants are used in nanoparticle synthesis (Mittal et al. 2013; Narayanan and Sakthivel 2010). Currently, most of the applications of AgNPs are in the biotechnology field as antibacterial and antifungal agents, in textile engineering, in wastewater treatment and as silver-based consumer products (Gade et al. 2010). Nanoparticles, which are mainly utilised in biomedical applications, fall within the size range of 1100 nm. The bioinspired method is considered to be ideal, amongst different synthetic routes to nanoparticle formation, since it avoids the use of toxic chemicals (Mittal et al. 2014).

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