Keserü György - Thermodynamics and Kinetics of Drug Binding, Volume 65

Methods and Principles in Medicinal Chemistry

Edited by R. Mannhold, H. Kubinyi, G. Folkers

Editorial Board:

H. Buschmann, H. Timmerman, H. van de Waterbeemd

Previous Volumes of this Series:

Pfannkuch, Friedlieb / Suter-Dick, Laura (Eds.)

Predictive Toxicology

From Vision to Reality

2014

ISBN: 978-3-527-33608-1

Vol. 64

Kirchmair, Johannes (Ed.)

Drug Metabolism Prediction

2014

ISBN: 978-3-527-33566-4

Vol. 63

Vela, Jos Miguel / Maldonado, Rafael / Hamon, Michel (Eds.)

In vivo Models for Drug Discovery

2014

ISBN: 978-3-527-33328-8

Vol. 62

Liras, Spiros / Bell, Andrew S. (Eds.)

Phosphodiesterases and Their Inhibitors

2014

ISBN: 978-3-527-33219-9

Vol. 61

Hanessian, Stephen (Ed.)

Natural Products in Medicinal Chemistry

2014

ISBN: 978-3-527-33218-2

Vol. 60

Lackey, Karen / Roth, Bruce (Eds.)

Medicinal Chemistry Approaches to Personalized Medicine

2013

ISBN: 978-3-527-33394-3

Vol. 59

Brown, Nathan (Ed.)

Scaffold Hopping in Medicinal Chemistry

2013

ISBN: 978-3-527-33364-6

Vol. 58

Hoffmann, Rmy / Gohier, Arnaud / Pospisil, Pavel (Eds.)

Data Mining in Drug Discovery

2013

ISBN: 978-3-527-32984-7

Vol. 57

Dmling, Alexander (Ed.)

Protein-Protein Interactions in Drug Discovery

2013

ISBN: 978-3-527-33107-9

Vol. 56

Kalgutkar, Amit S. / Dalvie, Deepak / Obach, R. Scott / Smith, Dennis A.

Reactive Drug Metabolites

2012

ISBN: 978-3-527-33085-0

Vol. 55

Series Editors

Prof. Raimund Mannhold

Rosenweg 7

40489 Dsseldorf

Germany

Prof. Hugo Kubinyi

Donnersbergstrasse 9

67256 Weisenheim am Sand

Germany

Prof. Gerd Folkers

Collegium Helveticum

STW/ETH Zurich

8092 Zurich

Switzerland

Volume Editors

Prof. Dr. Gyrgy M. Keser

Research Centre for Natural Sciences

Hungarian Academy of Sciences

Magyar tudsok krtja 2

1117 Budapest

Hungary

Dr. David C. Swinney

Institute for Rare and Neglected Diseases Drug Discovery

897 Independence Ave.

Mountain View, CA 94043

USA

Cover

The cover picture was created from a crystal structure of the heat shock protein 90 (HSP90) cocrystallyzed with the ligand of 4-CHLORO-6-(2-METHOXYPHENYL)PYRIMIDIN-2-AMINE (PDB code: 2XDX) by kos Tarcsay. The structure is available at http://www.pdb.org/pdb/explore/explore. do?structureId=2XDX. More information on the ligand and the target is available in Murray, C.W., Carr, M.G., Callaghan,O., Chessari, G., Congreve,M., Cowan, S., Coyle, J.E., Downham, R., Figueroa, E., Frederickson, M., Graham,B., Mcmenamin, R., O'Brien, M.A., Patel, S., Phillips, T.R., Williams, G., Woodhead,A.J., Woolford, A.J.A. (2010) J. Med. Chem. , 5942 5955.

PubMed: 20718493 DOI: 10.1021/jm100059d

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Eleanor K. H. Allen

Stony Brook University

Department of Chemistry

Institute for Chemical Biology and Drug Discovery

John S. Toll Drive

Stony Brook, NY 11794

USA

Pelin Ayaz

Bayer Healthcare Pharmaceuticals

Lead Discovery Berlin

Mllerstrase 178

13353 Berlin

Germany

Antoni R. Blaazer

VU University Amsterdam

Division of Medicinal Chemistry

Faculty of Sciences

Amsterdam Institute for Molecules, Medicines and Systems (AIMMS)

De Boelelaan 1083

1081 HV Amsterdam

The Netherlands

Pier Andrea Borea

University of Ferrara

Department of Medical Sciences

Pharmacology section, via Fossato di Mortara 17-19

44121 Ferrara

Italy

Andrew Chang

Stony Brook University

Department of Chemistry

Institute for Chemical Biology and Drug Discovery

John S. Toll Drive

Stony Brook, NY 11794

USA

Robert A. Copeland

Epizyme, Inc.

400 Technology Square

4th Floor

Cambridge, MA 02139

USA

Gareth Davies

Structure and Biophysics

Discovery Sciences

AstraZeneca, Mereside

Alderley Park

Macclesfield

Cheshire SK10 4TG

UK

Iwan J. P. de Esch

VU University Amsterdam

Division of Medicinal Chemistry

Faculty of Sciences

Amsterdam Institute for Molecules, Medicines and Systems (AIMMS)

De Boelelaan 1083

1081 HV Amsterdam

The Netherlands

Gyrgy G. Ferenczy

Hungarian Academy of Sciences

Research Centre for Natural Sciences

Medicinal Chemistry Research Group

Magyar tudsok krtja 2

1117 Budapest

Hungary

Ernesto Freire

The Johns Hopkins University

Department of Biology

3400 North Charles

Baltimore, MD 21218

USA

Jonathan C. Fuller

Molecular and Cellular Modeling Group

Heidelberg Institute for Theoretical Studies

Schloss-Wolfsbrunnenweg 35

69118 Heidelberg

Germany

Stefania Gessi

University of Ferrara

Department of Medical Sciences

Pharmacology section, via Fossato di Mortara 17-19

44121 Ferrara

Italy

Dong Guo

Leiden University

Department of Medicinal Chemistry

Einsteinweg 55

2333CC Leiden

The Netherlands

Laura H. Heitman

Leiden University

Department of Medicinal Chemistry

Einsteinweg 55

2333CC Leiden

The Netherlands

Geoffrey A. Holdgate

Structure and Biophysics

Discovery Sciences

AstraZeneca, Mereside

Alderley Park

Macclesfield

Cheshire SK10 4TG

UK

Walter Huber

F. Hoffmann-La Roche AG

Pharma Research and Early Development

Grenzacherstrasse 124

4070 Basel

Switzerland

Adriaan P. Ijzerman

Leiden University