Syed Z. Ali MD FRCPath FIAC - Atlas of Exfoliative Cytopathology: With Histopathologic Correlations

Contents

i Atlas of Exfoliative Cytopathology

ii

Syed Z. Ali, MD, FRCPath, FIAC

Professor of Pathology and Radiology

Director of Cytopathology

The Johns Hopkins University School of Medicine

Baltimore, Maryland

Christopher J. VandenBussche, MD, PhD

Assistant Professor of Pathology

Associate Director of Cytopathology

The Johns Hopkins University School of Medicine

Baltimore, Maryland

Cheng-Ying Ho, MD, PhD

Assistant Professor of Pathology

University of Maryland School of Medicine

Baltimore, Maryland

Doreen N. Palsgrove, MD

Postdoctoral Fellow

Departments of Pathology and Oncology

The Johns Hopkins Hospital

Baltimore, Maryland

Derek B. Allison, MD

Chief Resident, Department of Pathology

The Johns Hopkins Hospital

Baltimore, Maryland

Ashley Cimino-Mathews, MD

Associate Professor of Pathology and Oncology

Director of the Division of Breast Pathology

The Johns Hopkins University School of Medicine

Baltimore, Maryland

iii

Atlas of Exfoliative Cytopathology

With Histopathologic Correlations

iv Visit our website at www.springerpub.com

ISBN: 9781620701102

ebook ISBN: 9781617052873

Acquisitions Editor: David DAddona

Compositor: diacriTech

Copyright 2018 Springer Publishing Company.

Demos Medical Publishing is an imprint of Springer Publishing Company, LLC.

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Medicine is an ever-changing science. Research and clinical experience are continually expanding our knowledge, in particular our understanding of proper treatment and drug therapy. The authors, editors, and publisher have made every effort to ensure that all information in this book is in accordance with the state of knowledge at the time of production of the book. Nevertheless, the authors, editors, and publisher are not responsible for errors or omissions or for any consequences from application of the information in this book and make no warranty, expressed or implied, with respect to the contents of the publication. Every reader should examine carefully the package inserts accompanying each drug and should carefully check whether the dosage schedules mentioned therein or the contraindications stated by the manufacturer differ from the statements made in this book. Such examination is particularly important with drugs that are either rarely used or have been newly released on the market.

Library of Congress Cataloging-in-Publication Data

Names: Ali, Syed Z., author. | VandenBussche, Christopher J., author. | Ho, Cheng-Ying (Of Childrens National Medical Center), author.

Title: Atlas of exfoliative cytopathology with histopathologic correlations / Syed Z. Ali, Christopher J. VandenBussche, Cheng-Ying Ho.

Description: New York : Demos Medical, [2018] | Includes index.

Identifiers: LCCN 2017045222| ISBN 9781620701102 | ISBN 9781617052873 (e-book)

Subjects: | MESH: Serous Membranecytology | Serous Membranepathology | Body Fluid Compartmentsdiagnostic imaging | Neoplastic Cells, Circulatingpathology | Cytodiagnosismethods | Histological Techniquesmethods | Atlases

Classification: LCC QP90.5 | NLM QS 517 | DDC 612/.01522dc23

LC record available at https://lccn.loc.gov/2017045222

Printed in the United States of America by Sheridan Books, Inc.

17 18 19 20 21 / 5 4 3 2 1

v To my mentors, Drs. Steve I. Hajdu, Yener S. Erozan, and Dorothy L. Rosenthal.Syed Z. Ali

To my father, Tom, and his parents, Albert and Gertrude.Christopher J. VandenBussche

To my lovely daughter, Josephine Louise.Cheng-Ying Ho

To Andy, for his unwavering love and support.Doreen N. Palsgrove

To my father, who gave me a passion for science; my mother, who always supported me; and my wife and son, who inspire me daily.Derek B. Allison

To my family, with love.Ashley Cimino-Mathews vi

vii Contents

Lukas Bubendorf, MD

viii

ix Foreword

Translating cellular morphology to a definite diagnosis that guides treatment decisions is at the very heart of cytopathology. The diagnostic precision of each individual cytopathologist grows with every new specimen and is enhanced by the continuous correlation with histology and clinical findings. The enormous spectrum of changes that we see under the microscope requires good guidance in order not to get lost in what might appear as visual and biological chaos. Although every case is unique, classification and grouping of recurring observations help us to find our way to the right diagnosis. In this regard, illustrated textbooks continue to play an important role as a solid reference and good guide through the professional life of every cytopathologist. Despite the rapid progress in ancillary methods and molecular testing that we are experiencing in cytopathology, superb morphological diagnosis remains the cornerstone for all further downstream analyses and clinical decisions. It is my true pleasure to write a foreword to this outstanding work, which is destined to serve as a trusty guide in a large and important field of non-gynecological cytopathology. Atlas of Exfoliative Cytopathology With Histopathologic Correlations covers the wide spectrum of cytological findings in a well-organized format. The volume is divided into six chapters. A treasure of more than 500 high-resolution images illustrates the cytomorphologic characteristics and the differential diagnostic challenges associated with exfoliative cytology across different organ systems. The exquisite figures catch the essentials of a specific condition and each of them is supplemented by a concise description. Beyond morphology, the authors have also incorporated contemporary immunohistochemistry and histological correlations that further enrich our understanding. Urinary tract and gynecologic cytopathology specimens have been excluded as two previous volumes in the series have already broadly covered those topics. This Atlas has grown out of the fruitful ground of the Johns Hopkins Division of Cytopathology, where Dr. Ali and his team of co-authors are internationally well known as brilliant teachers and cytopathologists dedicated to moving the field forward.

Although there is no shortage of textbooks, atlases and virtual image databases in the field of cytopathology, Atlas of Exfoliative Cytopathology With Histopathologic Correlations stands out as a most practical volume tailored to assist cytopathologists in their daily diagnostic work irrespective of their level of experience. Besides enjoying the perfume of newly printed book pages, many of us will appreciate having this kind of atlas within easy reach. The authors should be congratulated on this excellent contribution.