Boulis Nicholas M - Molecular and Cellular Therapies for Motor Neuron Diseases

1. Tables in Chapter 2
2. Tables in Chapter 3
3. Tables in Chapter 4
4. Tables in Chapter 5
5. Tables in Chapter 11
6. Tables in Chapter 12

1. Figures in Chapter 1
2. Figures in Chapter 4
3. Figures in Chapter 5
4. Figures in Chapter 6
5. Figures in Chapter 7
6. Figures in Chapter 8
7. Figures in Chapter 9
8. Figures in Chapter 10
9. Figures in Chapter 11

Edited by

Nicholas Boulis

Deirdre OConnor

Anthony Donsante

Emory University, Atlanta, GA, United States

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N. Boulis , Emory University, Atlanta, GA, United States

R. Bowser , St Josephs Hospital and Medical Center, Phoenix, AZ, United States

A.H.M. Burghes , The Ohio State University, Columbus, OH, United States

K.S. Chen , University of Michigan, Ann Arbor, MI, United States

M. Collins , St Josephs Hospital and Medical Center, Phoenix, AZ, United States

S. Corti

University of Milan, Milan, Italy

IRCCS Foundation Ca Granda Ospedale Maggiore Policlinico, Milan, Italy

A. Donsante , Emory University, Atlanta, GA, United States

I. Faravelli

University of Milan, Milan, Italy

IRCCS Foundation Ca Granda Ospedale Maggiore Policlinico, Milan, Italy

E.L. Feldman , University of Michigan, Ann Arbor, MI, United States

J.D. Glass , Emory University, Atlanta, GA, United States

L. Karumbaiah , The University of Georgia, Athens, GA, United States

K.P. Kenna , University of Massachusetts Medical School, Worcester, MA, United States

J.E. Landers , University of Massachusetts Medical School, Worcester, MA, United States

C.L. Lorson , University of Missouri, Columbia, MO, United States

B.J. Mader , Emory University, Atlanta, GA, United States

M.J. Magnussen , Emory University, Atlanta, GA, United States

A. McDonough , Emory University, Atlanta, GA, United States

V.L. McGovern , The Ohio State University, Columbus, OH, United States

M.R. Miller , University of Missouri, Columbia, MO, United States

D.M. O'Connor , Emory University, Atlanta, GA, United States

E.Y. Osman , University of Missouri, Columbia, MO, United States

S.L. Stice , The University of Georgia, Athens, GA, United States

R.L. Swetenburg , The University of Georgia, Athens, GA, United States

N. Ticozzi

IRCCS Istituto Auxologico Italiano, Milan, Italy

Dino Ferrari Center Universit degli Studi di Milano, Milan, Italy

L. Urquia , Emory University, Atlanta, GA, United States

This book is dedicated to the people diagnosed with this disease and their families, who have refused to take no for an answer and have dedicated themselves to raising funding for research and volunteering for risky groundbreaking clinical trials, including Josh Thompson and his family, Ed Tesoro, Ted Harada, and Christina Clark.

R.L. Swetenburg, S.L. Stice and L. Karumbaiah, The University of Georgia, Athens, GA, United States

Motor neurons (MNs) are a diverse group of cells without which life would not be possible. MNs are responsible for integrating signals from the brain and the sensory systems to control all voluntary and involuntary movement, along with parts of the autonomic nervous system. Here, we focus on the specification and maturation of spinal MNs as they are a key target of disease and injury, as well as regenerative efforts. MNs arise from progenitors in the ventral neural tube and migrate into columns and pools. Notably, these progenitors later generate oligodendrocyte precursor cells. MN axons then travel outside of the central nervous system to reach their targets under guidance cues from the extracellular matrix. These cells are targets of devastating diseases including amyotrophic lateral sclerosis, spinal muscular atrophy, multiple sclerosis, as well as spinal cord injuries. By decoding the major events and players in development, we can better recapitulate them in vitro for cell replacement therapy, or harness the underlying principles for regeneration in the adult.